{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:05:16Z","timestamp":1791266716584,"version":"4.1.0"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2016,11,11]],"date-time":"2016-11-11T00:00:00Z","timestamp":1478822400000},"content-version":"vor","delay-in-days":338,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Coxiella burnetii is a rare cause of chronic infection that most frequently presents as endocarditis. We report a case of C burnetii causing an infected abdominal aortic aneurysm with contiguous lumbar osteomyelitis resulting in spinal cord compromise. The diagnosis was established by serologic studies consistent with chronic Q-fever (ratio of C burnetii immunoglobulin [Ig]G phase II titer to IgG phase I titer &amp;lt;1) and was confirmed by positive C burnetii polymerase chain reaction of vertebral tissue in addition to pathology of vertebral bone showing intracellular Gram-negative coccobacillary bacteria. The patient clinically improved after surgical decompression and prolonged treatment with doxycycline and hydroxychloroquine.<\/jats:p>","DOI":"10.1093\/ofid\/ofv185","type":"journal-article","created":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T04:05:06Z","timestamp":1449720306000},"source":"Crossref","is-referenced-by-count":15,"title":["Chronic Q-Fever (Coxiella burnetii) Causing Abdominal Aortic Aneurysm and Lumbar Osteomyelitis: A Case Report"],"prefix":"10.1093","volume":"3","author":[{"given":"P. Alexander","family":"Leahey","sequence":"first","affiliation":[{"name":"Divisions of Infectious Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Tahan","sequence":"additional","affiliation":[{"name":"Pathology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekkehard M.","family":"Kasper","sequence":"additional","affiliation":[{"name":"Neurosurgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Albrecht","sequence":"additional","affiliation":[{"name":"Divisions of Infectious Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,12,9]]},"reference":[{"key":"2020081005270098200_OFV185C1","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1093\/cid\/cis734","article-title":"Q fever: single-point source outbreak with high attack rates and massive numbers of undetected infections across an entire region","volume":"55","author":"Hackert","year":"2012","journal-title":"Clin Infect Dis"},{"key":"2020081005270098200_OFV185C2","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S1473-3099(03)00804-1","article-title":"Q fever: a biological weapon in your backyard","volume":"3","author":"Madariaga","year":"2003","journal-title":"Lancet Infect Dis"},{"key":"2020081005270098200_OFV185C3","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1128\/CMR.12.4.518","article-title":"Q fever","volume":"12","author":"Maurin","year":"1999","journal-title":"Clin Microbiol Rev"},{"key":"2020081005270098200_OFV185C4","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jvs.2005.03.022","article-title":"Abdominal aortic aneurysm and Coxiella burnetii infection: report of three cases and review of the literature","volume":"42","author":"Sessa","year":"2005","journal-title":"J Vasc Surg"},{"key":"2020081005270098200_OFV185C5","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1086\/516255","article-title":"Coxiella burnetii infection of aneurysms or vascular grafts: report of seven cases and review","volume":"26","author":"Fournier","year":"1998","journal-title":"Clin Infect Dis"},{"key":"2020081005270098200_OFV185C6","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.jvs.2006.09.016","article-title":"Coxiella burnetii infection of an aortic graft with multiple vertebral body erosion","volume":"45","author":"O'Donnell","year":"2007","journal-title":"J Vasc Surg"},{"key":"2020081005270098200_OFV185C7","doi-asserted-by":"crossref","first-page":"350","DOI":"10.3201\/eid1703.100882","article-title":"Q fever in France, 1985\u20132009","volume":"17","author":"Frankel","year":"2011","journal-title":"Emerg Infect Dis"},{"key":"2020081005270098200_OFV185C8","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1128\/JCM.02352-12","article-title":"A case of Q fever prosthetic joint infection and description of an assay for detection of Coxiella burnetii","volume":"51","author":"Tande","year":"2013","journal-title":"J Clin Microbiol"},{"key":"2020081005270098200_OFV185C9","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1093\/jac\/dkr450","article-title":"Guidelines for the diagnosis and antibiotic treatment of endocarditis in adults: a report of the Working Party of the British Society for Antimicrobial Chemotherapy","volume":"67","author":"Gould","year":"2012","journal-title":"J Antimicrob Chemother"}],"container-title":["Open Forum Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ofid\/article-pdf\/3\/1\/ofv185\/33600834\/ofv185.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ofid\/article-pdf\/3\/1\/ofv185\/33600834\/ofv185.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T09:27:52Z","timestamp":1597051672000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ofid\/article\/doi\/10.1093\/ofid\/ofv185\/2460434"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,9]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ofid\/ofv185","relation":{},"ISSN":["2328-8957"],"issn-type":[{"value":"2328-8957","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2016]]},"published":{"date-parts":[[2015,12,9]]},"article-number":"ofv185"}}