{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T22:31:16Z","timestamp":1793658676207,"version":"4.5.1"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2016,11,25]],"date-time":"2016-11-25T00:00:00Z","timestamp":1480032000000},"content-version":"vor","delay-in-days":329,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Association pour la Promotion de l\u2032Enseignement et de la Recherche en Mycologie"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Background. \u2003Early diagnosis and treatment are crucial in invasive fungal diseases (IFD). Serum (1-3)-\u03b2-d-glucan (BG) is believed to be an early IFD marker, but its diagnostic performance has been ambiguous, with insufficient data regarding sensitivity at the time of IFD diagnosis (TOD) and according to outcome. Whether its clinical utility is equivalent for all types of IFD remains unknown.<\/jats:p>\n               <jats:p>Methods. \u2003We included 143 patients with proven or probable IFD (49 invasive candidiasis, 45 invasive aspergillosis [IA], and 49 rare IFD) and analyzed serum BG (Fungitell) at TOD and during treatment.<\/jats:p>\n               <jats:p>Results. \u2003(1-3)-\u03b2-d-glucan was undetectable at TOD in 36% and 48% of patients with candidemia and IA, respectively; there was no correlation between negative BG results at TOD and patients' characteristics, localization of infection, or prior antifungal use. Nevertheless, patients with candidemia due to Candida albicans were more likely to test positive for BG at TOD (odds ratio = 25.4, P = .01) than patients infected with other Candida species. In 70% of the patients with a follow-up, BG negativation occurred in &amp;gt;1 month for candidemia and &amp;gt;3 months for IA. A slower BG decrease in patients with candidemia was associated with deep-seated localizations (P = .04). Thirty-nine percent of patients with rare IFD had undetectable BG at TOD; nonetheless, all patients with chronic subcutaneous IFD tested positive at TOD.<\/jats:p>\n               <jats:p>Conclusions. \u2003Undetectable serum BG does not rule out an early IFD, when the clinical suspicion is high. After IFD diagnostic, kinetics of serum BG are difficult to relate to clinical outcome.<\/jats:p>","DOI":"10.1093\/ofid\/ofw128","type":"journal-article","created":{"date-parts":[[2016,6,17]],"date-time":"2016-06-17T02:19:38Z","timestamp":1466129978000},"source":"Crossref","is-referenced-by-count":61,"title":["Prospective Evaluation of Serum \u03b2-Glucan Testing in Patients With Probable or Proven Fungal Diseases"],"prefix":"10.1093","volume":"3","author":[{"given":"C\u00e9cile","family":"Angebault","sequence":"first","affiliation":[{"name":"Unit\u00e9 de Parasitologie-Mycologie, Service de Microbiologie Clinique"},{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris-Cit\u00e9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Lanternier","sequence":"additional","affiliation":[{"name":"Centre d'Infectiologie Necker Pasteur"},{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris-Cit\u00e9"},{"name":"Unit\u00e9 de Mycologie M\u00e9dicale, Centre National de R\u00e9f\u00e9rence Mycoses Invasives et Antifongiques, Institut Pasteur, Paris"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Dalle","sequence":"additional","affiliation":[{"name":"Service de Parasitologie-Mycologie"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Schrimpf","sequence":"additional","affiliation":[{"name":"Centre d'Infectiologie Necker Pasteur"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Laure","family":"Roupie","sequence":"additional","affiliation":[{"name":"Centre d'Infectiologie Necker Pasteur"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Dupuis","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Parasitologie-Mycologie, Service de Microbiologie 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Clinique, Centre Hospitalier Universitaire Dijon Bourgogne"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9n\u00e9dicte","family":"Neven","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d'Immunologie, H\u00e9matologie et Rhumatologie P\u00e9diatriques"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Frange","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d'Immunologie, H\u00e9matologie et Rhumatologie P\u00e9diatriques"},{"name":"Unit\u00e9 d'Hygi\u00e8ne, Service de Microbiologie Clinique, H\u00f4pital Necker-Enfants malades, Assistance Publique des H\u00f4pitaux de Paris"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Suarez","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie Adulte"},{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris-Cit\u00e9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"d'Enfert","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Biologie et Pathog\u00e9nicit\u00e9 Fongiques, D\u00e9partement de Mycologie, Institut Pasteur, Paris"},{"name":"Institut National de la Recherche Agronomique, Unit\u00e9 Sous Contrat 2019, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Lortholary","sequence":"additional","affiliation":[{"name":"Centre d'Infectiologie Necker Pasteur"},{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris-Cit\u00e9"},{"name":"Unit\u00e9 de Mycologie M\u00e9dicale, Centre National de R\u00e9f\u00e9rence Mycoses Invasives et Antifongiques, Institut Pasteur, Paris"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Elisabeth","family":"Bougnoux","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Parasitologie-Mycologie, Service de Microbiologie Clinique"},{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris-Cit\u00e9"},{"name":"Unit\u00e9 Biologie et Pathog\u00e9nicit\u00e9 Fongiques, D\u00e9partement de Mycologie, Institut Pasteur, Paris"},{"name":"Institut National de la Recherche Agronomique, Unit\u00e9 Sous Contrat 2019, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,6,16]]},"reference":[{"key":"2020081006272624800_OFW128C1","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1086\/651263","article-title":"Prospective surveillance for invasive fungal infections in hematopoietic stem cell transplant recipients, 2001\u20132006: overview of the Transplant-Associated Infection Surveillance Network (TRANSNET) database","volume":"50","author":"Kontoyiannis","year":"2010","journal-title":"Clin Infect Dis"},{"key":"2020081006272624800_OFW128C2","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1086\/651262","article-title":"Invasive 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