{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T12:49:28Z","timestamp":1782218968936,"version":"3.54.5"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2016,11,25]],"date-time":"2016-11-25T00:00:00Z","timestamp":1480032000000},"content-version":"vor","delay-in-days":329,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Ambizione-PROSPER"},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"crossref","award":["PZ00P3_154730"],"award-info":[{"award-number":["PZ00P3_154730"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Background. \u2003We evaluated the prevalence of chronic hepatitis B virus (HBV) infection and liver fibrosis\/cirrhosis in human immunodeficiency virus (HIV)-infected individuals enrolled in a rural Tanzanian prospective cohort and assessed hepatic fibrosis progression 12\u201324 months after antiretroviral treatment (ART) initiation.<\/jats:p>\n               <jats:p>Methods. \u2003All ART-naive HIV-infected adults \u226515-year-old enrolled in the Kilombero and Ulanga Antiretroviral Cohort who started ART between 2005 and 2015 were included. Pre-ART factors associated with significant liver fibrosis (aspartate aminotransferase-to-platelet ratio index [APRI] &amp;gt;1.5) and cirrhosis (APRI &amp;gt; 2.0) were identified using logistic regression.<\/jats:p>\n               <jats:p>Results. \u2003Of 3097 individuals screened, 227 (7.3%; 95% CI, 6.4\u20138.2) were hepatitis B surface antigen (HBsAg) positive. Before ART initiation, 9.1% individuals had significant liver fibrosis and 5.3% had cirrhosis. Human immunodeficiency virus\/HBV-coinfected individuals were more likely to have an APRI score indicating significant fibrosis (14.2% vs 8.7%, P = .03) and cirrhosis (9.2% vs 4.9%, P = .03) than HBV-uninfected patients. CD4 cell count &amp;lt;200 cell\/\u03bcL and alcohol consumption were independently associated with pre-ART APRI score, indicating significant fibrosis and cirrhosis in multivariable analyses. Among individuals with elevated APRI measurements pre- and 12\u201324 months post-ART initiation, 53 of 57 (93.0%) of HIV-monoinfected and 4 of 5 (80.0%) of HIV\/HBV-coinfected had a regression to APRI &amp;lt; 1.5.<\/jats:p>\n               <jats:p>Conclusions. \u2003Hepatic fibrosis and cirrhosis were common in our cohort, especially among HIV\/HBV-coinfected individuals. The APRI improved in most patients. Pre-ART HBsAg screening and early onset of tenofovir-based ART for HIV\/HBV-coinfection should be prioritized in sub-Saharan Africa.<\/jats:p>","DOI":"10.1093\/ofid\/ofw162","type":"journal-article","created":{"date-parts":[[2016,7,30]],"date-time":"2016-07-30T01:59:25Z","timestamp":1469843965000},"source":"Crossref","is-referenced-by-count":24,"title":["Prevalence and Outcomes of Hepatitis B Coinfection and Associated Liver Disease Among Antiretroviral Therapy-Naive Individuals in a Rural Tanzanian Human Immunodeficiency Virus Cohort"],"prefix":"10.1093","volume":"3","author":[{"given":"Adri\u00e0","family":"Ram\u00edrez-Mena","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Infectious Diseases, University Hospital Son Espases, Palma de Mallorca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy R.","family":"Glass","sequence":"additional","affiliation":[{"name":"Swiss Tropical and Public Health Institute of 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