{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:47:27Z","timestamp":1762004847804,"version":"3.41.2"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"4","funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI100560, R01AI063517, and R01AI072219"],"award-info":[{"award-number":["R01AI100560, R01AI063517, and R01AI072219"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012729","name":"Clinical and Translational Science Collaborative of Cleveland","doi-asserted-by":"crossref","award":["UL1TR000439"],"award-info":[{"award-number":["UL1TR000439"]}],"id":[{"id":"10.13039\/100012729","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Veterans Affairs Merit Review Program","award":["1I01BX001974"],"award-info":[{"award-number":["1I01BX001974"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Identifying the pathogen responsible for culture-negative valve endocarditis often depends on molecular studies performed on surgical specimens. A patient with Ehlers-Danlos syndrome who had an aortic graft, a mechanical aortic valve, and a mitral anulloplasty ring presented with culture-negative prosthetic valve endocarditis and aortic graft infection. Research-based polymerase chain reaction (PCR)\/electrospray ionization mass spectrometry on peripheral blood samples identified Bartonella henselae. Quantitative PCR targeting the16S-23S ribonucleic acid intergenic region and Western immunoblotting confirmed this result. This, in turn, permitted early initiation of pathogen-directed therapy and subsequent successful medical management of B henselae prosthetic valve endocarditis and aortic graft infection.<\/jats:p>","DOI":"10.1093\/ofid\/ofw202","type":"journal-article","created":{"date-parts":[[2016,10,2]],"date-time":"2016-10-02T00:09:55Z","timestamp":1475366995000},"source":"Crossref","is-referenced-by-count":2,"title":["Prosthetic Valve Endocarditis Caused by Bartonella henselae: A Case Report of Molecular Diagnostics Informing Nonsurgical Management"],"prefix":"10.1093","volume":"3","author":[{"given":"Patricia","family":"Bartley","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases and HIV Medicine, Department of Medicine, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanouil","family":"Angelakis","sequence":"additional","affiliation":[{"name":"Aix-Marseille Universit\u00e9, Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Raoult","sequence":"additional","affiliation":[{"name":"Aix-Marseille Universit\u00e9, Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rangarajan","family":"Sampath","sequence":"additional","affiliation":[{"name":"Ibis Biosciences, Inc., Carlsbad, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Bonomo","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and HIV Medicine, Department of Medicine, and"},{"name":"Departments of Pathology, Pharmacology, and Molecular Biology and Microbiology and Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio"},{"name":"Geriatric Research Education and Clinical Center, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin L. 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