{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:26:36Z","timestamp":1790303196895,"version":"4.1.0"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2016,11,25]],"date-time":"2016-11-25T00:00:00Z","timestamp":1480032000000},"content-version":"vor","delay-in-days":329,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Brazilian Council for Development of Science and Technology"},{"name":"CAPES Foundation"},{"DOI":"10.13039\/501100006366","name":"Brazilian Ministry of Education","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006366","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Rio de Janeiro Foundation"},{"name":"D\u2019Or Institute for Research and Education"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Brazil has experienced a Zika virus (ZIKV) outbreak with increased incidence of congenital malformations and neurological manifestations. We describe a case of a 26-year-old Brazilian Caucasian man infected with ZIKV and diagnosed with encephalomyelitis. Brain and spinal cord images showed hyperintense lesions on T2 and fluid-attenuated inversion recovery (FLAIR), and levels of proinflammatory cytokines in the cerebrospinal fluid showed a remarkable increase of interleukin (IL)-6 and IL-8. The observed pattern suggests immune activation during the acute phase, along with the neurological impairment, with normalization in the recovery phase. This is the first longitudinal report of ZIKV infection causing encephalomyelitis with documented immune activation.<\/jats:p>","DOI":"10.1093\/ofid\/ofw203","type":"journal-article","created":{"date-parts":[[2016,10,4]],"date-time":"2016-10-04T02:59:00Z","timestamp":1475549940000},"source":"Crossref","is-referenced-by-count":39,"title":["Zika Virus Causing Encephalomyelitis Associated With Immunoactivation"],"prefix":"10.1093","volume":"3","author":[{"given":"Rafael Mello","family":"Galliez","sequence":"first","affiliation":[{"name":"Instituto Estadual de Infectologia S\u00e3o Sebasti\u00e3o, Rio de Janeiro, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Cl\u00ednica M\u00e9dica da Faculdade de Medicina da Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Spitz","sequence":"additional","affiliation":[{"name":"University of the State of Rio de Janeiro, Brazil"},{"name":"Neurology Service and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia Piazza","family":"Rafful","sequence":"additional","affiliation":[{"name":"D\u2019Or Institute for Research and Education, Rio de Janeiro, Brazil"},{"name":"Radiology Department, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Cagy","sequence":"additional","affiliation":[{"name":"University of the State of Rio de Janeiro, Brazil"},{"name":"Neurology Service and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Escosteguy","sequence":"additional","affiliation":[{"name":"Epidemiology Service, Hospital Federal dos Servidores do Estado, Rio de Janeiro, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline Sp\u00f3sito Brito","family":"Germano","sequence":"additional","affiliation":[{"name":"University of the State of Rio de Janeiro, Brazil"},{"name":"Neurology Service and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Sasse","sequence":"additional","affiliation":[{"name":"University of the State of Rio de Janeiro, Brazil"},{"name":"Neurology Service and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro Luis","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Genetics Department, Biology Institute, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola Paz","family":"Silveira","sequence":"additional","affiliation":[{"name":"Genetics Department, Biology Institute, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Pezzuto","sequence":"additional","affiliation":[{"name":"Genetics Department, Biology Institute, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice Maria de Magalh\u00e3es","family":"Ornelas","sequence":"additional","affiliation":[{"name":"Genetics Department, Biology Institute, 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