{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:33:05Z","timestamp":1760189585418,"version":"3.41.2"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T00:00:00Z","timestamp":1505347200000},"content-version":"vor","delay-in-days":256,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,11,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A 47-year-old man with HIV infection presented 10 years after initial secondary syphilis diagnosis and treatment for routine follow-up. His HIV was well controlled on antiretroviral therapy. Rapid plasma reagin was 1:1, and TP-PA was reactive. Physical examination revealed a wide pulse pressure, a systolic murmur, and an early diastolic decrescendo murmur. Echocardiogram revealed moderate to severe aortic regurgitation, and subsequent computed tomography angiogram showed a 6.8-cm fusiform aneurysm of the proximal ascending aorta. Aortic valve and ascending hemiarch replacement were performed. Pathology showed adventitial inflammation with plasma cells, gumma-like amorphous areas surrounded by histiocytes, and giant cells with calcified plaques. Cardiovascular syphilis, while rare, remains a relevant cause of aortic aneurysm, even in previously treated patients. The physical exam can be critical in identifying this potentially fatal complication.<\/jats:p>","DOI":"10.1093\/ofid\/ofx198","type":"journal-article","created":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T16:35:33Z","timestamp":1505406933000},"source":"Crossref","is-referenced-by-count":7,"title":["Asymptomatic Cardiovascular Syphilis With Aortic Regurgitation Requiring Surgical Repair in an HIV-Infected Patient"],"prefix":"10.1093","volume":"4","author":[{"given":"Daniel S","family":"Graciaa","sequence":"first","affiliation":[{"name":"Department of Medicine, Emory University School of Medicine, Atlanta, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina B","family":"Mosunjac","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly A","family":"Workowski","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russell R","family":"Kempker","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,9,14]]},"reference":[{"volume-title":"Sexually Transmitted Disease Surveillance 2015","year":"2016","author":"Centers for Disease Control and Prevention","key":"2020081005180799200_CIT0001"},{"key":"2020081005180799200_CIT0002","first-page":"3","article-title":"The Oslo study of untreated syphilis; an epidemiologic investigation of the natural course of the syphilitic infection based upon a re-study of the Boeck-Bruusgaard material","volume":"35","author":"Gjestland","year":"1955","journal-title":"Acta Derm Venereol Suppl (Stockh)"},{"key":"2020081005180799200_CIT0003","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0002-9343(89)80826-5","article-title":"Cardiovascular syphilis","volume":"87","author":"Jackman","year":"1989","journal-title":"Am J Med"},{"key":"2020081005180799200_CIT0004","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1016\/j.amjcard.2009.07.031","article-title":"Natural history of syphilitic aortitis","volume":"104","author":"Roberts","year":"2009","journal-title":"Am J Cardiol"},{"key":"2020081005180799200_CIT0005"},{"key":"2020081005180799200_CIT0006"},{"key":"2020081005180799200_CIT0007","article-title":"Syphilis","author":"Hook","year":"2016","journal-title":"Lancet"},{"key":"2020081005180799200_CIT0008","doi-asserted-by":"crossref","first-page":"i3309","DOI":"10.1136\/bmj.i3309","article-title":"How valuable is physical examination of the cardiovascular system?","volume":"354","author":"Elder","year":"2016","journal-title":"BMJ"},{"key":"2020081005180799200_CIT0009","volume-title":"Cardiovascular Pathology","author":"Silver","year":"2001","edition":"3rd ed"},{"key":"2020081005180799200_CIT0010","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.1016\/j.jacc.2010.02.015","article-title":"2010 ACCF\/AHA\/AATS\/ACR\/ASA\/SCA\/SCAI\/SIR\/STS\/SVM guidelines for the diagnosis and management of patients with thoracic aortic disease. A Report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines, American Association for Thoracic Surgery, American College of Radiology, American Stroke Association, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society of Interventional Radiology, Society of Thoracic Surgeons, and Society for Vascular Medicine","volume":"55","author":"Hiratzka","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"2020081005180799200_CIT0011","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1016\/S0003-4975(99)00431-2","article-title":"Surgical intervention criteria for thoracic aortic aneurysms: a study of growth rates and complications","volume":"67","author":"Coady","year":"1999","journal-title":"Ann Thorac Surg"}],"container-title":["Open Forum Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ofid\/article-pdf\/4\/4\/ofx198\/33623915\/ofx198.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ofid\/article-pdf\/4\/4\/ofx198\/33623915\/ofx198.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T09:22:34Z","timestamp":1597051354000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ofid\/article\/doi\/10.1093\/ofid\/ofx198\/4158427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,11,20]]}},"URL":"https:\/\/doi.org\/10.1093\/ofid\/ofx198","relation":{},"ISSN":["2328-8957"],"issn-type":[{"type":"electronic","value":"2328-8957"}],"subject":[],"published-other":{"date-parts":[[2017]]},"published":{"date-parts":[[2017]]},"article-number":"ofx198"}}