{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T15:34:51Z","timestamp":1785080091955,"version":"3.55.0"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2017,11,2]],"date-time":"2017-11-02T00:00:00Z","timestamp":1509580800000},"content-version":"vor","delay-in-days":305,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Australian National Health and Medical Research Council","award":["1088735"],"award-info":[{"award-number":["1088735"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Skin and soft tissue infections (SSTI) affect millions of people globally, which represents a significant burden on ambulatory care and hospital settings. The role of sulfamethoxazole-trimethoprim (SXT) in SSTI treatment, particularly when group A Streptococcus (GAS) is involved, is controversial. We conducted a systematic review of clinical trials and observational studies that address the utility of SXT for SSTI treatment, caused by either GAS or Staphylococcus aureus, including methicillin-resistant (MRSA). We identified 196 studies, and 15 underwent full text review by 2 reviewers. Observational studies, which mainly focused on SSTI due to S aureus, supported the use of SXT when compared with clindamycin or \u03b2-lactams. Of 10 randomized controlled trials, 8 demonstrated the efficacy of SXT for SSTI treatment including conditions involving GAS. These findings support SXT use for treatment of impetigo and purulent cellulitis (without an additional \u03b2-lactam agent) and abscess and wound infection. For nonpurulent cellulitis, \u03b2-lactams remain the treatment of choice.<\/jats:p>","DOI":"10.1093\/ofid\/ofx232","type":"journal-article","created":{"date-parts":[[2017,11,2]],"date-time":"2017-11-02T16:26:29Z","timestamp":1509639989000},"source":"Crossref","is-referenced-by-count":56,"title":["Sulfamethoxazole-Trimethoprim (Cotrimoxazole) for Skin and Soft Tissue Infections Including Impetigo, Cellulitis, and Abscess"],"prefix":"10.1093","volume":"4","author":[{"given":"Asha C","family":"Bowen","sequence":"first","affiliation":[{"name":"Wesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Perth"},{"name":"Princess Margaret Hospital for Children, Perth, Western Australia"},{"name":"Menzies School of Health Research, Charles Darwin University, North Territory, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan R","family":"Carapetis","sequence":"additional","affiliation":[{"name":"Wesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Perth"},{"name":"Princess Margaret Hospital for Children, Perth, Western Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart J","family":"Currie","sequence":"additional","affiliation":[{"name":"Menzies School of Health Research, Charles Darwin University, North Territory, Australia"},{"name":"Royal Darwin Hospital, North Territory, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Vance","family":"Fowler","sequence":"additional","affiliation":[{"name":"Duke University Division of Infectious Diseases, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry F","family":"Chambers","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, Department of Medicine, San Francisco General Hospital, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven Y C","family":"Tong","sequence":"additional","affiliation":[{"name":"Menzies School of Health Research, Charles Darwin University, North Territory, Australia"},{"name":"Victorian Infectious Disease Service, The Royal Melbourne Hospital, and The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,11,2]]},"reference":[{"key":"2020081005280679300_CIT0001","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1093\/cid\/ciu444","article-title":"Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by The Infectious Diseases Society of America","volume":"59","author":"Stevens","year":"2014","journal-title":"Clin Infect 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