{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T17:08:24Z","timestamp":1783616904055,"version":"3.55.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2017,11,18]],"date-time":"2017-11-18T00:00:00Z","timestamp":1510963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI97096"],"award-info":[{"award-number":["R01AI97096"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The importance of antibody immunity in protection against Cryptococcus neoformans remains unresolved. We measured serum C neoformans-specific and total antibody levels and peripheral blood B cell subsets of 12 previously healthy patients with cryptococcosis (cases) and 21 controls. Before and after adjustment for age, sex, and race, cryptococcal capsular polysaccharide immunoglobulin G was higher in cases than controls, whereas total B and memory B cell levels were lower. These associations parallel previous findings in patients with human immunodeficiency virus-associated cryptococcosis and suggest that B cell subset perturbations may also associate with disease in previously normal individuals with cryptococcosis.<\/jats:p>","DOI":"10.1093\/ofid\/ofx255","type":"journal-article","created":{"date-parts":[[2017,11,18]],"date-time":"2017-11-18T16:31:29Z","timestamp":1511022689000},"source":"Crossref","is-referenced-by-count":32,"title":["Antibody and B Cell Subset Perturbations in Human Immunodeficiency Virus-Uninfected Patients With Cryptococcosis"],"prefix":"10.1093","volume":"5","author":[{"given":"Soma","family":"Rohatgi","sequence":"first","affiliation":[{"name":"Department of Biotechnology, IIT-Roorkee, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Nakouzi","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro J","family":"Carre\u00f1o","sequence":"additional","affiliation":[{"name":"Millennium Institute on Immunology and Immunotherapy, Programa de Inmunolog\u00eda, Instituto de Ciencias Biom\u00e9dicas, Facultad de Medicina, Universidad de Chile, Santiago"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Slosar-Cheah","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, IIT-Roorkee, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark H","family":"Kuniholm","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, University at Albany, State University of New York, Rensselaer, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter G","family":"Pappas","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of Alabama at Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liise-anne","family":"Pirofski","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York"},{"name":"Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,11,18]]},"reference":[{"key":"2020081004065076300_CIT0001","doi-asserted-by":"crossref","first-page":"e1004884","DOI":"10.1371\/journal.ppat.1004884","article-title":"Paradoxical immune responses in 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