{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T20:37:28Z","timestamp":1772483848109,"version":"3.50.1"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T00:00:00Z","timestamp":1527552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1113638"],"award-info":[{"award-number":["1113638"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Prevention of rheumatic heart disease (RHD) remains challenging in high-burden settings globally. After acute rheumatic fever (ARF), secondary antibiotic prophylaxis is required to prevent RHD. International guidelines on recommended durations of secondary prophylaxis differ, with scope for clinician discretion. Because ARF risk decreases with age, ongoing prophylaxis is generally considered unnecessary beyond approximately the third decade. Concordance with guidelines on timely cessation of prophylaxis is unknown.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We undertook a register-based audit to determine the appropriateness of antibiotic prophylaxis among clients aged \u226535 years in Australia\u2019s Northern Territory. Data on demographics, ARF episode(s), RHD severity, prophylaxis type, and relevant clinical notes were extracted. The determination of guideline concordance was based on whether (1) national guidelines were followed; (2) a reason for departure from guidelines was documented; (3) lifelong continuation was considered appropriate in all cases of severe RHD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We identified 343 clients aged \u226535 years prescribed secondary prophylaxis. Guideline concordance was 39% according to national guidelines, 68% when documented reasons for departures from guidelines were included and 82% if patients with severe RHD were deemed to need lifelong prophylaxis. Shorter times since last echocardiogram or cardiologist review were associated with greater likelihood of guideline concordance (P &amp;lt; .001). The median time since last ARF was 5.9 years in the guideline-concordant group and 24.0 years in the nonconcordant group (P &amp;lt; .001). Thirty-two people had an ARF episode after age 40 years.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In this setting, appropriate discontinuation of RHD prophylaxis could be improved through timely specialist review to reduce unnecessary burden on clients and health systems.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofy125","type":"journal-article","created":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T17:45:14Z","timestamp":1527615914000},"source":"Crossref","is-referenced-by-count":8,"title":["Rheumatic Heart Disease Prophylaxis in Older Patients: A Register-Based Audit of Adherence to Guidelines"],"prefix":"10.1093","volume":"5","author":[{"given":"James V","family":"Holland","sequence":"first","affiliation":[{"name":"MBBS, Monash University, Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"Hardie","sequence":"additional","affiliation":[{"name":"Department of Health, Centre for Disease Control, Darwin, Northern Territory, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"de Dassel","sequence":"additional","affiliation":[{"name":"Department of Health, Centre for Disease Control, Darwin, Northern Territory, Australia"},{"name":"Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna P","family":"Ralph","sequence":"additional","affiliation":[{"name":"Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia"},{"name":"Division of Medicine, Royal Darwin Hospital, Darwin, Northern Territory, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,5,29]]},"reference":[{"key":"2020081004291798600_CIT0001","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1161\/CIRCULATIONAHA.113.001477","article-title":"Acute rheumatic fever and rheumatic heart disease: incidence and progression in the Northern Territory of Australia, 1997 to 2010","volume":"128","author":"Lawrence","year":"2013","journal-title":"Circulation"},{"key":"2020081004291798600_CIT0002","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1111\/j.1445-5994.1997.tb01000.x","article-title":"Ten-year follow up of a cohort with rheumatic heart disease (RHD)","volume":"27","author":"Carapetis","year":"1997","journal-title":"Aust N Z J Med"},{"key":"2020081004291798600_CIT0003","first-page":"CD002227","article-title":"Penicillin for secondary prevention of rheumatic fever","volume":"2002; (3)","author":"Manyemba","journal-title":"Cochrane Database Syst Rev"},{"key":"2020081004291798600_CIT0004","doi-asserted-by":"crossref","first-page":"e259","DOI":"10.1097\/INF.0b013e3181a8e12a","article-title":"Meta-analysis of trials of streptococcal throat treatment programs to prevent rheumatic fever","volume":"28","author":"Lennon","year":"2009","journal-title":"Pediatr Infect Dis J"},{"key":"2020081004291798600_CIT0005","first-page":"212","article-title":"Intramuscular penicillin is more effective than oral penicillin in secondary prevention of rheumatic fever\u2013a systematic review","volume":"93","author":"Manyemba","year":"2003","journal-title":"S Afr Med J"},{"key":"2020081004291798600_CIT0006","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/s12872-016-0344-x","article-title":"Sharing success - understanding barriers and enablers to secondary prophylaxis delivery for rheumatic fever and rheumatic heart disease","volume":"16","author":"Chamberlain-Salaun","year":"2016","journal-title":"BMC Cardiovasc Disord"},{"key":"2020081004291798600_CIT0007","doi-asserted-by":"crossref","DOI":"10.2174\/1573403X13666170116120828","article-title":"Adherence to secondary prophylaxis for acute rheumatic fever and rheumatic heart disease: a systematic review","author":"Kevat","year":"2017; 13:155\u201366","journal-title":"Curr Cardiol Rev"},{"key":"2020081004291798600_CIT0008","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13063-016-1166-y","article-title":"Improving delivery of secondary prophylaxis for rheumatic heart disease in remote Indigenous communities: study protocol for a stepped-wedge randomised trial","volume":"17","author":"Ralph","year":"2016","journal-title":"Trials"},{"key":"2020081004291798600_CIT0009","article-title":"Ralph AP, de Dassel JL, Kirby A, et al. Improving delivery of secondary prophylaxis for rheumatic heart disease in a high-burden setting (the RHDSP trial): outcome of a stepped-wedge, community randomised trial. J Am Heart Assoc 2018 (in press)"},{"key":"2020081004291798600_CIT0010","volume-title":"The Australian Guideline for Prevention, Diagnosis and Management of Acute Rheumatic Fever and Rheumatic Heart Disease","author":"RHDAustralia (ARF\/RHD Writing Group)","year":"2012"},{"key":"2020081004291798600_CIT0011","volume-title":"Bicillin L-A\u00ae (Benthazine Benzylpenicillin) Deep Intramuscular Injection [package insert]","year":"2012"},{"key":"2020081004291798600_CIT0012","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1161\/CIR.0000000000000205","article-title":"Revision of the Jones Criteria for the diagnosis of acute rheumatic fever in the era of Doppler echocardiography: a scientific statement from the American Heart Association","volume":"131","author":"Gewitz","year":"2015","journal-title":"Circulation"},{"key":"2020081004291798600_CIT0013","volume-title":"iPhone and Android apps","author":"RHDAustralia","year":"2015"},{"key":"2020081004291798600_CIT0014","volume-title":"Acute Rheumatic Fever: Treatment and Prevention Waltham, MA: UpToDateInc","author":"Steer","year":"2017"},{"key":"2020081004291798600_CIT0015","volume-title":"Rheumatic Fever and Rheumatic Heart Disease: Report of a WHO Expert Consultation. WHO Technical Report Series","author":"World Health Organisation","year":"2001"},{"key":"2020081004291798600_CIT0016","volume-title":"New Zealand Guidelines for Rheumatic Fever: Diagnosis, Management and Secondary Prevention of Acute Rheumatic Fever and Rheumatic Heart Disease: 2014 Update","author":"Heart Foundation of New Zealand","year":"2014"},{"key":"2020081004291798600_CIT0017","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1161\/CIRCULATIONAHA.109.191959","article-title":"Prevention of rheumatic fever and diagnosis and treatment of acute streptococcal pharyngitis: a scientific statement from the American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee of the Council on Cardiovascular Disease in the Young, the Interdisciplinary Council on Functional Genomics and Translational Biology, and the Interdisciplinary Council on Quality of Care and Outcomes Research: endorsed by the American Academy of Pediatrics","volume":"119","author":"Gerber","year":"2009","journal-title":"Circulation"},{"key":"2020081004291798600_CIT0018","first-page":"565","article-title":"Consensus guidelines on pediatric acute rheumatic fever and rheumatic heart disease","volume":"45","author":"Saxena","year":"2008","journal-title":"Indian Pediatr"},{"key":"2020081004291798600_CIT0019","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s12960-017-0229-9","article-title":"Patterns of resident health workforce turnover and retention in remote communities of the Northern Territory of Australia, 2013-2015","volume":"15","author":"Russell","year":"2017","journal-title":"Hum Resour Health"},{"key":"2020081004291798600_CIT0020","article-title":"\u201cThat heart sickness:\u201d young aboriginal people\u2019s understanding of rheumatic fever","author":"Mitchell","year":"","journal-title":"Med Anthropol"},{"key":"2020081004291798600_CIT0021","doi-asserted-by":"crossref","first-page":"e0178264","DOI":"10.1371\/journal.pone.0178264","article-title":"Adherence to secondary prophylaxis for rheumatic heart disease is underestimated by register data","volume":"12","author":"de Dassel","year":"2017","journal-title":"PLoS One"},{"key":"2020081004291798600_CIT0022","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0738-3991(02)00032-0","article-title":"Self-management approaches for people with chronic conditions: a review","volume":"48","author":"Barlow","year":"2002","journal-title":"Patient Educ Couns"},{"key":"2020081004291798600_CIT0023","article-title":"What does a culturally competent model of self-management look like","author":"Wade","year":"2017","journal-title":"RHD Australia News"},{"key":"2020081004291798600_CIT0024","volume-title":"Cardiovascular Disease: Australian Facts 2011. Cardiovascular Disease Series","author":"Australian Institute of Health and Welfare","year":"2011"}],"container-title":["Open Forum Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ofid\/article-pdf\/5\/6\/ofy125\/33577630\/ofy125.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ofid\/article-pdf\/5\/6\/ofy125\/33577630\/ofy125.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T08:32:50Z","timestamp":1597048370000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ofid\/article\/doi\/10.1093\/ofid\/ofy125\/5022672"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,29]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ofid\/ofy125","relation":{},"ISSN":["2328-8957"],"issn-type":[{"value":"2328-8957","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,6,1]]},"published":{"date-parts":[[2018,5,29]]},"article-number":"ofy125"}}