{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:42:48Z","timestamp":1791420168856,"version":"4.3.3"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2018,6,11]],"date-time":"2018-06-11T00:00:00Z","timestamp":1528675200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Scleritis is an inflammatory process involving the outer coating of the globe which is characterized by focal or diffuse hyperemia, moderate to severe pain, and frequent impairment of vision. Most cases of scleritis are autoimmune in nature and are managed with topical and\/or systemic corticosteroids. Infectious scleritis is a less common entity, occurring in 5%\u201310% of cases, and requiring directed antimicrobial therapy. We present a case of Nocardia farcinica anterior nodular scleritis diagnosed via positive culture of an excisional biopsy of a scleral nodule. The patient improved after combined surgical and medical therapy with amoxicillin-clavulanate and moxifloxacin for 12 months. Based on a literature review, a summary of reported cases of infectious scleritis is provided, and guidelines pertaining to diagnosis and management are offered.<\/jats:p>","DOI":"10.1093\/ofid\/ofy140","type":"journal-article","created":{"date-parts":[[2018,6,11]],"date-time":"2018-06-11T04:57:49Z","timestamp":1528693069000},"source":"Crossref","is-referenced-by-count":18,"title":["Infectious Scleritis: What the ID Clinician Should Know"],"prefix":"10.1093","volume":"5","author":[{"given":"Richelle L","family":"Guerrero-Wooley","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Loma Linda University Medical Center, Loma Linda, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"James E","family":"Peacock","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Wake Forest Baptist Medical Center, Winston Salem, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,6,11]]},"reference":[{"key":"2020081004284578800_CIT0001","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1097\/ICO.0000000000000174","article-title":"Infectious scleritis in Taiwan\u2014a 10-year review in a tertiary-care hospital","volume":"33","author":"Ho","year":"2014","journal-title":"Cornea"},{"key":"2020081004284578800_CIT0002","first-page":"2113","article-title":"Clinical characteristics and visual outcomes in infectious scleritis: a review","volume":"7","author":"Ramenaden","year":"2013","journal-title":"Clin Ophthalmol"},{"key":"2020081004284578800_CIT0003","doi-asserted-by":"crossref","first-page":"203","DOI":"10.4103\/0974-9233.150634","article-title":"Risk factors and clinical outcomes of bacterial and fungal scleritis at a tertiary eye care hospital","volume":"22","author":"Reddy","year":"2015","journal-title":"Middle East Afr J 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infectious scleritis: experience from a tertiary eye care center of India","volume":"2012","author":"Kumar Sahu","year":"2012","journal-title":"Int J Inflam"},{"key":"2020081004284578800_CIT0008","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/BF01203568","article-title":"Infectious scleritis: report of four cases","volume":"83","author":"de la Maza","year":"1993","journal-title":"Doc Ophthalmol"},{"key":"2020081004284578800_CIT0009","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s12348-012-0062-1","article-title":"Early surgical debridement in the management of infectious scleritis after pterygium excision","volume":"2","author":"Tittler","year":"2012","journal-title":"J Ophthalmic Inflamm Infect"},{"key":"2020081004284578800_CIT0010","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1097\/ICO.0b013e318259c952","article-title":"Epidemiology and visual outcomes in patients with infectious scleritis","volume":"32","author":"Hodson","year":"2013","journal-title":"Cornea"},{"key":"2020081004284578800_CIT0011","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1097\/ICO.0b013e31820967bd","article-title":"Management and outcome of microbial anterior scleritis","volume":"30","author":"Cunningham","year":"2011","journal-title":"Cornea"},{"key":"2020081004284578800_CIT0012","doi-asserted-by":"crossref","first-page":"590","DOI":"10.4103\/0301-4738.121085","article-title":"Infectious scleritis: clinical spectrum and management outcomes in India","volume":"61","author":"Pradhan","year":"2013","journal-title":"Indian J Ophthalmol"},{"key":"2020081004284578800_CIT0013","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1136\/bjo.81.11.980","article-title":"Clinical experiences of infectious scleral ulceration: a complication of pterygium operation","volume":"81","author":"Lin","year":"1997","journal-title":"Br J 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