{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T19:18:09Z","timestamp":1789845489448,"version":"4.0.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"9","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HHSN261200800001E"],"award-info":[{"award-number":["HHSN261200800001E"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Invasive aspergillosis (IA) is the most serious mold infection encountered in patients with iatrogenic immunosuppression. IA is also a major cause of mortality and morbidity in individuals with primary immunodeficiency (PID). Although Aspergillus fumigatus is the most common etiologic agent of IA reported in PID patients, followed by A. nidulans, multiple poorly recognized Aspergillus species such as A. udagawae, A. quadrilineatus, A. pseudoviridinutans, A. tanneri, A. subramanianii, and A. fumisynnematus have been reported almost exclusively from patients with inborn defects in host antifungal defense pathways. Infection in PID patients exhibits patterns of disease progression distinct from those in iatrogenic immunosuppression. Specifically, the disease can be extrapulmonary and chronic with a tendency to disseminate in a contiguous manner across anatomical planes. It is also more refractory to standard antifungal therapy. This synopsis summarizes our understanding of emerging rare Aspergillus species that primarily affect patients with PIDs but not those with acquired immunodeficiencies.<\/jats:p>","DOI":"10.1093\/ofid\/ofy213","type":"journal-article","created":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T12:34:29Z","timestamp":1537965269000},"source":"Crossref","is-referenced-by-count":38,"title":["Emerging Aspergillus Species Almost Exclusively Associated With Primary Immunodeficiencies"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6194-7447","authenticated-orcid":false,"given":"S","family":"Seyedmousavi","sequence":"first","affiliation":[{"name":"Molecular Microbiology Section, National Institutes of Health, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M S","family":"Lionakis","sequence":"additional","affiliation":[{"name":"Fungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Parta","sequence":"additional","affiliation":[{"name":"Clinical Research Directorate\/Clinical Monitoring Research Program, Frederick National Laboratory for Cancer Research, sponsored by the National Cancer Institute, Frederick, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S W","family":"Peterson","sequence":"additional","affiliation":[{"name":"National Center for Agricultural Utilization Research, US Department of Agriculture, Peoria, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K J","family":"Kwon-Chung","sequence":"additional","affiliation":[{"name":"Molecular Microbiology Section, National Institutes of Health, Bethesda, 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