{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:14:11Z","timestamp":1753877651105,"version":"3.41.2"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T00:00:00Z","timestamp":1548720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"FIS","award":["PI08\/893","PI13\/02256","PI16\/01740"],"award-info":[{"award-number":["PI08\/893","PI13\/02256","PI16\/01740"]}]},{"name":"Contrato de Intensificaci\u00f3n de la Actividad Investigadora","award":["INT 14\/00207"],"award-info":[{"award-number":["INT 14\/00207"]}]},{"name":"Contrato R\u00edo Hortega","award":["CM15\/00187"],"award-info":[{"award-number":["CM15\/00187"]}]},{"name":"FISABIO","award":["UGP-14\u2013197","UGP-15\u2013152"],"award-info":[{"award-number":["UGP-14\u2013197","UGP-15\u2013152"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Human herpesvirus 8 (HHV-8) is a lymphotropic and vasculotropic herpesvirus with potential pro-atherogenic effects. We explored the influence of coinfection with HHV-8 and other herpesviruses on the rate of progression of carotid intima-media thickness (cIMT) in virologically suppressed people living with HIV (PLWH).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Prospective cohort study including men who have sex with men (MSM) infected with HIV. At the baseline visit, IgG antibodies against HHV-8 and other herpesviruses, highly sensitive C-reactive protein (hsCRP) levels, and Framingham risk scores were measured. To evaluate the progression of cIMT, successive measurements with high-resolution carotid artery ultrasound were performed over an 8-year period. Adjusted general linear mixed models were used to assess factors associated with faster cIMT progression.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>One hundred forty-one participants with suppressed HIV-RNA (&amp;lt;200 copies\/mL) at cIMT measurement during the study period were included. Forty-six (31.3%) were coinfected with HHV-8 and 76 (54%) with herpes simplex virus 2 (HSV-2). Factors associated with faster cIMT progression adjusting for CD4 cell counts, time between cIMT measurements, hepatitis C, varicella zoster virus, and cytomegalovirus coinfection were seropositivity for HHV-8 (P = .059), HSV-2+HHV-8 coinfection (P = .027), Framingham risk score (P = .057), and hsCRP (P = .027). Coinfection with HHV-8 was independently associated with higher levels of hsCRP (odds ratio, 1.09; 95% confidence interval, 1.02 to 1.17; P = .016). When hsCRP and HHV-8 were simultaneously included in the adjusted model, the relationship of HHV-8 with cIMT progression was attenuated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>HHV-8 might contribute to progression of cIMT with a more prominent role when it coinfects with HHV-2 in virologically suppressed PLWH, and this effect could be driven by systemic inflammation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofz041","type":"journal-article","created":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T07:56:26Z","timestamp":1548834986000},"source":"Crossref","is-referenced-by-count":4,"title":["Contribution of Human Herpesvirus 8 and Herpes Simplex Type 2 to Progression of Carotid Intima-Media Thickness in People Living With HIV"],"prefix":"10.1093","volume":"6","author":[{"given":"Fernando","family":"Lid\u00f3n","sequence":"first","affiliation":[{"name":"Infectious Diseases Unit, Hospital General Universitario de Elche and Universidad Miguel Hern\u00e1ndez, Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Padilla","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Hospital General Universitario de Elche and Universidad Miguel Hern\u00e1ndez, Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose A","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Statistics, Centro de Investigaci\u00f3n Operativa, Universidad Miguel Hern\u00e1ndez, Elche, Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Hospital General Universitario de Elche and Universidad Miguel Hern\u00e1ndez, Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Hospital General Universitario de Elche and Universidad Miguel Hern\u00e1ndez, Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Ortiz de la Tabla","sequence":"additional","affiliation":[{"name":"Microbiology Service, Hospital Universitario de San Juan, Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e9lix","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Hospital General Universitario de Elche and Universidad Miguel Hern\u00e1ndez, Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar","family":"Masi\u00e1","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Hospital General Universitario 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