{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T21:51:49Z","timestamp":1790459509413,"version":"4.1.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T00:00:00Z","timestamp":1550534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002997","name":"Dutch Kidney Foundation","doi-asserted-by":"publisher","award":["13A1D302"],"award-info":[{"award-number":["13A1D302"]}],"id":[{"id":"10.13039\/501100002997","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>BK polyomavirus (BKPyV)\u2013associated nephropathy (BKPyVAN) is a major threat for kidney transplant recipients (KTRs). The role of specific BKPyV genotypes\/serotypes in development of BKPyVAN is poorly understood. Pretransplantation serotyping of kidney donors and recipients and posttransplantation genotyping of viremic recipients, could reveal the clinical relevance of specific BKPyV variants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort of 386 living kidney donor-recipient pairs was serotyped before transplantation against BKPyV genotype I\u2013IV viral capsid protein 1 antigen, using a novel BKPyV serotyping assay. Replicating BKPyV isolates in viremic KTRs after transplantation were genotyped using real-time polymerase chain reaction and confirmed by means of sequencing. BKPyV serotype and genotype data were used to determine the source of infection and analyze the risk of viremia and BKPyVAN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Donor and recipient BKPyV genotype and serotype distribution was dominated by genotype I (&amp;gt;80%), especially Ib, over II, III and IV. Donor serotype was significantly correlated with the replicating genotype in viremic KTRs (P &amp;lt; .001). Individual donor and recipient serotype, serotype (mis)matching and the recipient replicating BKPyV genotype were not associated with development of viremia or BKPyVAN after transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>BKPyV donor and recipient serotyping and genotyping indicates the donor origin of replicating BKPyV in viremic KTRs but provides no evidence for BKPyV genotype\u2013specific virulence.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ofid\/ofz078","type":"journal-article","created":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T20:15:46Z","timestamp":1550607346000},"source":"Crossref","is-referenced-by-count":28,"title":["Source and Relevance of the BK Polyomavirus Genotype for Infection After Kidney Transplantation"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9491-0790","authenticated-orcid":false,"given":"H F","family":"Wunderink","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology, Leiden University Medical Center, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C S","family":"De Brouwer","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Leiden University Medical Center, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Gard","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, University Medical Center Groningen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J W","family":"De Fijter","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Leiden University Medical Center, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A C M","family":"Kroes","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Leiden University Medical Center, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J I","family":"Rotmans","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Leiden University Medical Center, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M C W","family":"Feltkamp","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Leiden University Medical Center, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,2,19]]},"reference":[{"key":"2020081003472722100_CIT0001","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S1473-3099(03)00770-9","article-title":"Polyomavirus BK","volume":"3","author":"Hirsch","year":"2003","journal-title":"Lancet Infect Dis"},{"key":"2020081003472722100_CIT0002","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1111\/apm.12134","article-title":"The human polyomavirus BK (BKPyV): 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