{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T04:18:26Z","timestamp":1775017106177,"version":"3.50.1"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2019,4,13]],"date-time":"2019-04-13T00:00:00Z","timestamp":1555113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Disseminated strongyloidiasis in solid organ transplant recipients is a rare but devastating infection. In our center, we implemented a universal screening of all candidates for kidney transplantation. We assessed the seroprevalence and utility of universal screening for strongyloidiasis in our center.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients were identified from our transplant referral list (from July 2012 to June 2017). Demographics, pretransplant laboratory, and serological screenings were retrospectively collected. For Strongyloides-seropositive (SSp) patients, data on travel history, symptoms, treatment, and stool ova and parasite examinations were extracted. Logistic regression and multiple imputation for missing data were performed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 1689 patients underwent serological screening, of whom 168 (9.9%) were SSp. Univariate analysis revealed that SSp patients had higher rates of eosinophilia, diabetes mellitus, latent tuberculosis and were likely to be either Hispanic or Asian (P &amp;lt; .05). In multivariate analysis, eosinophilia (P = .01), diabetes mellitus (P = .02), and Asian race (P = .03) were associated with being SSp, but 45 (27%) of the SSp patients did not have any of these 3 factors, and 18 SSp patients (11%) had no epidemiological risk factors. All patients received ivermectin, and none developed disseminated strongyloidiasis. Of patients who underwent serological screening on multiple occasions, 6.8% seroconverted while waiting for kidney transplantation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We found a high rate of Strongyloides seropositivity among our kidney transplantation candidates. No epidemiological risk factors effectively predicted SSp status in our population, and universal screening identified a large number of patients without such factors. Serial screening should be considered when a long wait time is expected before transplantation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofz172","type":"journal-article","created":{"date-parts":[[2019,4,13]],"date-time":"2019-04-13T07:12:29Z","timestamp":1555139549000},"source":"Crossref","is-referenced-by-count":23,"title":["Seroprevalence of Strongyloides stercoralis and Evaluation of Universal Screening in Kidney Transplant Candidates: A Single-Center Experience in Houston (2012\u20132017)"],"prefix":"10.1093","volume":"6","author":[{"given":"Mohanad","family":"Al-Obaidi","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, McGovern Medical School, University of Texas Health Science Center at Houston"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Hasbun","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, McGovern Medical School, University of Texas Health Science Center at Houston"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen J","family":"Vigil","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, McGovern Medical School, University of Texas Health Science Center at Houston"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelina R","family":"Edwards","sequence":"additional","affiliation":[{"name":"Division of Renal Disease and Hypertension, McGovern Medical School, University of Texas Health Science Center at Houston"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Violeta","family":"Chavez","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, McGovern Medical School, University of Texas Health Science Center at Houston"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R","family":"Hall","sequence":"additional","affiliation":[{"name":"Division of Immunology and Organ Transplantation, McGovern Medical School, University of Texas Health Science Center at Houston"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wasim A","family":"Dar","sequence":"additional","affiliation":[{"name":"Division of Immunology and Organ Transplantation, McGovern Medical School, University of Texas Health Science Center at Houston"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"De Golovine","sequence":"additional","affiliation":[{"name":"Division of Renal Disease and Hypertension, McGovern Medical School, University of Texas Health Science Center at Houston"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Ostrosky-Zeichner","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, McGovern Medical School, University of Texas Health Science Center at Houston"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John S","family":"Bynon","sequence":"additional","affiliation":[{"name":"Division of Immunology and Organ Transplantation, McGovern Medical School, University of Texas Health Science Center at Houston"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Nigo","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, McGovern Medical School, University of Texas Health Science Center at Houston"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,4,13]]},"reference":[{"key":"2020081003565197700_CIT0001","author":"Centers for Disease Control and Prevention. 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