{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T06:52:00Z","timestamp":1784357520469,"version":"3.55.0"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T00:00:00Z","timestamp":1570752000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Few reports of Talaromyces marneffei (TM) or cryptococcosis infections among HIV-negative patients with high-titeranti\u2013IFN-\u03b3autoantibodies (nAIGAs) have been published. We investigated the clinical manifestations of patients with nAIGAs and TM infections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>HIV-negative adults (\u226518 years) were enrolled if they haddisseminated TM infection (group 1; further divided into nAIGAs positive [group 1P] and negative [group 1N]); cryptococcosis(pulmonary cryptococcosis and\/or cryptococcosis of the brain)(group 2); pulmonary tuberculosis (group 3); and healthy controls (group 4) with nAIGAs detected. Complete histories, physical examinations, and routine clinical laboratory tests were obtained at baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 88 participants were in the four groups (20,13,23, and 32 in groups 1 to 4, respectively). Significant differences occurred between groups with higher nAIGAs titers (P &amp;lt; 0.001), and higher total white-cell and absolute neutrophil counts (P &amp;lt; 0.001) in group1. Lungs (90.0%), lymph nodes (60.0%), skin (55.0%), and bones (50.0%) were most common sites of involvement. Significant differences in total white-cell and absolute neutrophil counts occurred between groups IP and 1N.Patients with recurrent TM infections, particularly group 1P, had higher initial nAIGA titer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with persistent infection who died tended to have positive initial nAIGA titer. It suggests that nAIGAs may play a critical role in the pathogenesis of TM infections, and may be associated with more severe, refractory infection.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ofid\/ofz208","type":"journal-article","created":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T12:39:14Z","timestamp":1570797554000},"source":"Crossref","is-referenced-by-count":31,"title":["Characterization of Anti\u2013Interferon-\u03b3 Antibodies in HIV-Negative Patients Infected With Disseminated Talaromyces marneffei and Cryptococcosis"],"prefix":"10.1093","volume":"6","author":[{"given":"Wen","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shudan","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianquan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mianluan","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoning","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,10,11]]},"reference":[{"key":"2020081004471951500_CIT0001","doi-asserted-by":"crossref","first-page":"e19","DOI":"10.1038\/emi.2016.18","article-title":"Talaromyces (Penicillium) marneffei infection in non-HIV-infected patients","volume":"5","author":"Chan","year":"2016","journal-title":"Emerg Microbes Infect"},{"key":"2020081004471951500_CIT0002","doi-asserted-by":"crossref","DOI":"10.1186\/s12879-015-1243-y","article-title":"Differences in clinical characteristics and prognosis of Penicilliosis among HIV-negative patients with or without underlying disease in Southern China: a retrospective study","volume":"15","author":"Qiu","year":"2015","journal-title":"BMC Infect Dis"},{"key":"2020081004471951500_CIT0003","doi-asserted-by":"crossref","first-page":"e3927","DOI":"10.1097\/MD.0000000000003927","article-title":"Clinical manifestations, course, and outcome of patients with neutralizing anti-interferon-\u03b3 autoantibodies and disseminated nontuberculous mycobacterial infections","volume":"95","author":"Chi","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"2020081004471951500_CIT0004","article-title":"Patient ethnicity and causative species determine the manifestations of anti-interferon-gamma autoantibody-associated nontuberculous mycobacterial disease: a review","volume":"88:308\u201315","author":"Hase","year":"2017","journal-title":"Diagn Microbiol Infect Dis"},{"key":"2020081004471951500_CIT0005","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1128\/CVI.00053-10","article-title":"Disseminated penicilliosis, recurrent bacteremic nontyphoidal salmonellosis, and burkholderiosis associated with acquired immunodeficiency due to autoantibody against gamma interferon","volume":"17","author":"Tang","year":"2010","journal-title":"Clin Vaccine Immunol"},{"key":"2020081004471951500_CIT0006","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1056\/NEJMoa1111160","article-title":"Adult-onset immunodeficiency in Thailand and Taiwan","volume":"367","author":"Browne","year":"2012","journal-title":"N Engl J Med"},{"key":"2020081004471951500_CIT0007","doi-asserted-by":"crossref","first-page":"428","DOI":"10.4103\/ijd.IJD_362_17","article-title":"Sweet\u2019s syndrome associated with Talaromyces marneffei and Mycobacterium abscessus infection due to anti-interferon-gamma autoantibodies","volume":"63","author":"Hongyan","year":"2018","journal-title":"Indian J Dermatol"},{"key":"2020081004471951500_CIT0008","doi-asserted-by":"crossref","first-page":"69","DOI":"10.7883\/yoken.JJID.2015.340","article-title":"Cryptococcosis in anti-interferon-gamma autoantibody-positive patients: a different clinical manifestation from HIV-infected patients","volume":"70","author":"Chetchotisakd","year":"2017","journal-title":"Japanese J Infect Dis"},{"key":"2020081004471951500_CIT0009","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.3760\/cma.j.issn.0366-6999.20131751","article-title":"Adult-onset immunodeficiency due to anti-interferon-gamma autoantibody in mainland Chinese","volume":"127","author":"Chan","year":"2014","journal-title":"Chinese Med J"},{"key":"2020081004471951500_CIT0010","doi-asserted-by":"crossref","first-page":"ofw093","DOI":"10.1093\/ofid\/ofw093","article-title":"Disseminated Talaromyces marneffei and Mycobacterium abscessus in a patient with anti-interferon-\u03b3 autoantibodies","volume":"3","author":"Pruetpongpun","year":"2016","journal-title":"Open Forum Infect Dis"},{"key":"2020081004471951500_CIT0011","doi-asserted-by":"crossref","first-page":"e0145983","DOI":"10.1371\/journal.pone.0145983","article-title":"Immune alterations in patients with anti-interferon-\u03b3 autoantibodies","volume":"11","author":"Chruewkamlow","year":"2016","journal-title":"PLOS ONE"},{"key":"2020081004471951500_CIT0012","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.1172\/JCI19316","article-title":"Acquired predisposition to mycobacterial disease due to autoantibodies to IFN-gamma","volume":"115","author":"Kampmann","year":"2005","journal-title":"J Clin Invest"},{"key":"2020081004471951500_CIT0013","article-title":"Characterization of anti-interferon-\u03b3 antibodies in HIV-negative immunodeficient patients infected with unusual intracellular microorganisms","volume":"243:621-6","author":"Wipasa","year":"2018","journal-title":"Exp Biol Med"},{"key":"2020081004471951500_CIT0014","doi-asserted-by":"crossref","first-page":"3933","DOI":"10.1182\/blood-2011-12-395707","article-title":"Anti-CD20 (rituximab) therapy for anti-IFN-\u03b3 autoantibody-associated nontuberculous mycobacterial infection","volume":"119","author":"Browne","year":"2012","journal-title":"Blood"},{"key":"2020081004471951500_CIT0015","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.4103\/0366-6999.180520","article-title":"Comparison of Talaromyces marneffei infection in human immunodeficiency virus-positive and human immunodeficiency virus-negative patients from Fujian, China","volume":"129","author":"Li","year":"2016","journal-title":"Chin Med J"},{"key":"2020081004471951500_CIT0016","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1007\/s10096-018-3222-x","article-title":"Susceptibility profile of echinocandins, azoles and amphotericin B against yeast phase of Talaromyces marneffei isolated from HIV-infected patients in Guangdong, China","volume":"37","author":"Lei","year":"2018","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"2020081004471951500_CIT0017","doi-asserted-by":"crossref","first-page":"e115","DOI":"10.1093\/cid\/cit809","article-title":"Rituximab as successful adjunct treatment in a patient with disseminated nontuberculous mycobacterial infection due to acquired anti-interferon-\u03b3 autoantibody","volume":"58","author":"Czaja","year":"2014","journal-title":"Clin Infect Dis"},{"key":"2020081004471951500_CIT0018","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.2165\/11201110-000000000-00000","article-title":"Rituximab: a review of its use in chronic lymphocytic leukaemia, low-grade or follicular lymphoma and diffuse large B-cell lymphoma","volume":"70","author":"Keating","year":"2010","journal-title":"Drugs"}],"container-title":["Open Forum Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ofid\/article-pdf\/6\/10\/ofz208\/33598619\/ofz208.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ofid\/article-pdf\/6\/10\/ofz208\/33598619\/ofz208.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T21:52:20Z","timestamp":1721857940000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ofid\/article\/doi\/10.1093\/ofid\/ofz208\/5585774"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,1]]},"references-count":18,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ofid\/ofz208","relation":{},"ISSN":["2328-8957"],"issn-type":[{"value":"2328-8957","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,10]]},"published":{"date-parts":[[2019,10,1]]},"article-number":"ofz208"}}