{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T19:01:17Z","timestamp":1767034877264,"version":"3.41.2"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although existing literature supports durations of 5\u20137 days for skin and soft tissue infections (SSTIs), longer durations are commonly used. Obesity and heart failure (HF) have been associated with increased risk for treatment failure of SSTIs; however, whether prolonged antibiotic durations reduce the risk of treatment failure is unknown. We evaluated practice patterns for SSTIs in patients with obesity and\/or HF and whether short antibiotic durations (\u22648 days) were associated with treatment failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a single-center, retrospective cohort study of inpatients between January 1, 2006, and December 30, 2016, with SSTIs based on International Classification of Diseases (ICD) coding, and obesity and\/or HF. Charts were manually reviewed to collect demographic, clinical, treatment, and outcome data. Propensity score matching was used to estimate the risk of treatment failure between the 2 groups. Secondary outcomes included length of stay, 30-day readmission, and Clostridium difficile infection rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 207 patients were included. Forty-nine (23.7%) received a short antibiotic duration and 158 (76.3%) a long duration. The median duration of therapy (interquartile range [IQR]) was 7 (7\u20138) days in the short group and 14 (10\u201315) days in the long group. In the propensity score\u2013matched cohort, 28 (28.6%) treatment failures occurred in the long group, as compared with 5 (10.2%) in the short group (P = .02), as well as a shorter length of stay (IQR) in the short- vs long-duration group (2 [2\u20133] vs 3 [2\u20135] days, respectively; P = .002). There was no difference in other secondary outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The majority of patients with obesity or HF received a longer antibiotic course for SSTIs; however, a longer antibiotic course was not associated with lower treatment failure rates. Higher failure rates in the long-duration group may be reflective of clinical decisions made in the face of diagnostic uncertainty and warrant further evaluation.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ofid\/ofz217","type":"journal-article","created":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T22:36:56Z","timestamp":1557268616000},"source":"Crossref","is-referenced-by-count":13,"title":["Treatment Duration and Associated Outcomes for Skin and Soft Tissue Infections in Patients With Obesity or Heart Failure"],"prefix":"10.1093","volume":"6","author":[{"given":"Claudia","family":"Ihm","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Utah, Salt Lake City, Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesse D","family":"Sutton","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center, Salt Lake City, Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tristan T","family":"Timbrook","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Utah Health, Salt Lake City, Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily S","family":"Spivak","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Utah, Salt Lake City, Utah"},{"name":"Veterans Affairs Medical Center, Salt Lake City, Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,5,7]]},"reference":[{"key":"2020081003570693900_CIT0001","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1086\/605562","article-title":"Infectious disease hospitalizations in the United States","volume":"49","author":"Christensen","year":"2009","journal-title":"Clin Infect Dis"},{"key":"2020081003570693900_CIT0002","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1186\/1471-2334-14-270","article-title":"Recurrent erysipelas\u2014risk factors and clinical presentation","volume":"14","author":"Inghammar","year":"2014","journal-title":"BMC Infect Dis"},{"key":"2020081003570693900_CIT0003","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1001\/archinte.167.7.709","article-title":"A predictive model of recurrent lower extremity cellulitis in a population-based cohort","volume":"167","author":"McNamara","year":"2007","journal-title":"Arch Intern Med"},{"key":"2020081003570693900_CIT0004","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jinf.2012.03.013","article-title":"Risk factors for clinical failure in patients hospitalized with cellulitis and cutaneous abscess","volume":"65","author":"Halilovic","year":"2012","journal-title":"J Infect"},{"key":"2020081003570693900_CIT0005","doi-asserted-by":"crossref","first-page":"e02389","DOI":"10.1128\/AAC.02389-16","article-title":"Obesity and heart failure as predictors of failure in outpatient skin and soft tissue infections","volume":"61","author":"Conway","year":"2017","journal-title":"Antimicrob. 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