{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:44:12Z","timestamp":1787312652574,"version":"build-2736575974"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2019,11,3]],"date-time":"2019-11-03T00:00:00Z","timestamp":1572739200000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A 7-year-old child of Turkish origin presented with headache and vomiting in the context of prolonged fever of unknown source. At examination, oral candidiasis and chronic onychomycosis were noted. A Candida meningoencephalitis was diagnosed and intravenous Amphotericin B liposomal was given during 6 months relayed by oral Fluconazole after regression of CNS lesions was observed on MRI. A complete immune evaluation was performed, and genetic analysis detected homozygous CARD9 mutation. CARD9 deficiency have been associated with invasive candidiasis in otherwise healthy patients.<\/jats:p>\n                  <jats:p>Culture of the cerebrospinal fluid grew for multisensitive Candida albicans. Brain magnetic resonance (MRI) showed the presence of focal lesions in the left caudate nucleus and in the right cerebellar hemisphere. Medullar MRI showed diffuse meningeal nodular lesions. Treatment with intravenous amphotericin B liposomal was given during 6 months relayed by oral fluconazole after regression of CNS lesions was observed on MRI.<\/jats:p>\n                  <jats:p>A complete immune evaluation was performed and genetic analysis detected a homozygous CARD9 mutation. CARD9 deficiency have been associated with invasive candidiasis in otherwise healthy patients.<\/jats:p>","DOI":"10.1093\/ofid\/ofz229","type":"journal-article","created":{"date-parts":[[2019,11,3]],"date-time":"2019-11-03T12:26:04Z","timestamp":1572783964000},"source":"Crossref","is-referenced-by-count":11,"title":["A 7-Year-Old Child With Headaches and Prolonged Fever Associated With Oral and Nail Lesions"],"prefix":"10.1093","volume":"6","author":[{"given":"Sophie","family":"Martin","sequence":"first","affiliation":[{"name":"General Pediatrics, Cliniques universitaires Saint-Luc, UCLouvain, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise","family":"Balligand","sequence":"additional","affiliation":[{"name":"General Pediatrics, Cliniques universitaires Saint-Luc, UCLouvain, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Peeters","sequence":"additional","affiliation":[{"name":"General Pediatrics, Ho\u0302pital de Jolimont, La Louvie\u0300re, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Ce\u0301cile","family":"Nassogne","sequence":"additional","affiliation":[{"name":"Neuropediatrics, Cliniques universitaires Saint-Luc, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Be\u0301ne\u0301dicte","family":"Mondovits","sequence":"additional","affiliation":[{"name":"Pediatrics and Neonatology, Clinique Saint-Jean, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miche\u0300le","family":"Loop","sequence":"additional","affiliation":[{"name":"Pediatrics and Neonatology, Clinique Saint-Jean, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"de Selys","sequence":"additional","affiliation":[{"name":"Pediatrics and Neonatology, Clinique Saint-Jean, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Vanclaire","sequence":"additional","affiliation":[{"name":"Pediatrics and Neonatology, Clinique Saint-Jean, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Vermylen","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology, Cliniques universitaires Saint-Luc, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean- Jacques","family":"De Bruyckere","sequence":"additional","affiliation":[{"name":"Department of Immunology and Rheumatology, Centre Hospitalier Universitaire Sainte-Justine, Montre\u0301al, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Chatzis","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Diseases, General Pediatrics, Cliniques universitaires Saint-Luc, UCLouvain, Brussels, 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Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,11,3]]},"reference":[{"key":"2019110312455775300_CIT0001","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1093\/cid\/civ1194","article-title":"Clinical practice guideline for the management of candidiasis: 2016 update by the Infectious Diseases Society of America","volume":"62","author":"Pappas","year":"2016","journal-title":"Clin Infect Dis"},{"key":"2019110312455775300_CIT0002","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/j.jaci.2014.12.1930","article-title":"Inherited CARD9 deficiency in otherwise healthy children and adults with Candida species-induced meningoencephalitis, colitis, or both","volume":"135","author":"Lanternier","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"2019110312455775300_CIT0003","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/s41419-017-0084-6","article-title":"Molecular 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