{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:21:30Z","timestamp":1790774490339,"version":"4.1.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T00:00:00Z","timestamp":1560297600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"National Institute for Health Research Manchester Biomedical Research Centre"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Malaria transmission through blood transfusion is an accidental but preventable cause of malaria infection and is increasingly becoming a matter of concern for blood transfusion services. This systematic review was conducted to provide a summary of evidence about the prevalence of Plasmodium infection in asymptomatic blood donors and the effectiveness of screening methods used based on the available literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PRISMA guidelines were followed. Scopus, PubMed, Science Direct, and EMBASE were searched from 1982 to October 10, 2017. All peer-reviewed original research articles describing the prevalence of malaria parasitemia in blood donors with different diagnostic methods were included. The random-effects model was applied to assess the effects of heterogeneity among the selected studies. Incoherence and heterogeneity between studies were quantified by I2 index and Cochran\u2019s Q test. Publication and population bias was assessed with funnel plots and Egger\u2019s regression asymmetry test. All statistical analyses were performed using Stata (version 2.7.2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seventy-one studies from 21 countries, 5 continents, were included in the present systematic review. The median prevalence of malaria parasitemia among 984 975 asymptomatic healthy blood donors was 10.54%, 5.36%, and 0.38% by microscopy, molecular methods (polymerase chain reaction), and rapid diagnostic tests, respectively. The most commonly detected Plasmodium species was P. falciparum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This systematic review demonstrates that compared with other transfusion-linked infections, that is, HIV, HCV, and HBV, transfusion-transmitted malaria is one of the most significant transfusion-associated infections especially in Sub-Saharan Africa. Future work must aim to understand the clinical significance of transfusion-transmitted malaria in malaria-endemic settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ofid\/ofz283","type":"journal-article","created":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T03:49:48Z","timestamp":1560311388000},"source":"Crossref","is-referenced-by-count":44,"title":["Transfusion-Transmitted Malaria: A Systematic Review and Meta-analysis"],"prefix":"10.1093","volume":"6","author":[{"given":"Ehsan","family":"Ahmadpour","sequence":"first","affiliation":[{"name":"Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoud","family":"Foroutan-Rad","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran"},{"name":"Abadan School of Medical Sciences, Abadan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamidreza","family":"Majidiani","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirous Mehrani","family":"Moghaddam","sequence":"additional","affiliation":[{"name":"Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kareem","family":"Hatam-Nahavandi","sequence":"additional","affiliation":[{"name":"Iranshahr University of Medical Sciences, Iranshahr, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed-Abdollah","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Taghi","family":"Rahimi","sequence":"additional","affiliation":[{"name":"School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Barac","sequence":"additional","affiliation":[{"name":"Clinic for Infectious and Tropical Diseases, Clinical Centre of Serbia, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Rubino","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Sassari, Sardinia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Zarean","sequence":"additional","affiliation":[{"name":"Department of Parasitology and Mycology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander G","family":"Mathioudakis","sequence":"additional","affiliation":[{"name":"Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muge","family":"Cevik","sequence":"additional","affiliation":[{"name":"Division of Infection and Global Health Research, School of Medicine, University of St Andrews, Fife, Scotland, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,6,11]]},"reference":[{"key":"2020081004182297600_CIT0001","volume-title":"Achieving the Malaria MDG Target: Reversing the Incidence of Malaria 2000\u20132015","author":"WHO, UNICEF","year":"2015"},{"key":"2020081004182297600_CIT0002","first-page":"136","article-title":"Transfusion-transmitted malaria in Iran: a narrative review article","volume":"11","author":"Mardani","year":"2016","journal-title":"Iran J Parasitol"},{"key":"2020081004182297600_CIT0003","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1128\/CMR.00059-07","article-title":"Malaria chemoprophylaxis: strategies for risk groups","volume":"21","author":"Schlagenhauf","year":"2008","journal-title":"Clin Microbiol Rev"},{"key":"2020081004182297600_CIT0004","doi-asserted-by":"crossref","first-page":"a025452","DOI":"10.1101\/cshperspect.a025452","article-title":"Biology of malaria transmission","volume":"7","author":"Meibalan","year":"2017","journal-title":"Cold Spring Harb Perspect Med"},{"key":"2020081004182297600_CIT0005","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1007\/s00134-004-2366-6","article-title":"Transfusion-transmitted malaria","volume":"30","author":"Bruneel","year":"2004","journal-title":"Intensive Care Med"},{"key":"2020081004182297600_CIT0006","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/j.1423-0410.2005.00610.x","article-title":"Transfusion-transmitted malaria: current donor selection guidelines are not sufficient","volume":"88","author":"Kitchen","year":"2005","journal-title":"Vox Sang"},{"key":"2020081004182297600_CIT0007","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1056\/NEJM200106283442603","article-title":"Transfusion-transmitted malaria in the United States from 1963 through 1999","volume":"344","author":"Mungai","year":"2001","journal-title":"N Engl J Med"},{"key":"2020081004182297600_CIT0008","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12936-018-2181-0","article-title":"A systematic review of transfusion-transmitted malaria in non-endemic areas","volume":"17","author":"Verra","year":"2018","journal-title":"Malar J"},{"key":"2020081004182297600_CIT0009","volume-title":"Manson\u2019s Tropical Diseases E-Book","author":"Farrar","year":"2013"},{"key":"2020081004182297600_CIT0010","doi-asserted-by":"crossref","first-page":"465\u2013474","DOI":"10.1186\/1475-2875-12-465","article-title":"What is the best strategy for the prevention of transfusion-transmitted malaria in Sub-Saharan African countries where malaria is endemic?","volume":"12","author":"Nansseu","year":"2013","journal-title":"Malar J"},{"key":"2020081004182297600_CIT0011","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1111\/j.1537-2995.2010.02872.x","article-title":"Survival of Plasmodium falciparum in human blood during refrigeration","volume":"51","author":"Chattopadhyay","year":"2011","journal-title":"Transfusion"},{"key":"2020081004182297600_CIT0012","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1423-0410.2006.00733.x","article-title":"Malaria and blood transfusion","volume":"90","author":"Kitchen","year":"2006","journal-title":"Vox Sang"},{"key":"2020081004182297600_CIT0013","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-3148.2009.00958.x","article-title":"The blood donor in Sub-Saharan Africa: a review","volume":"20","author":"Tagny","year":"2010","journal-title":"Transfus Med"},{"key":"2020081004182297600_CIT0014","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1086\/656806","article-title":"Transfusion-transmitted malaria in countries where malaria is endemic: a review of the literature from Sub-Saharan Africa","volume":"51","author":"Owusu-Ofori","year":"2010","journal-title":"Clin Infect Dis"},{"key":"2020081004182297600_CIT0015","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1086\/524888","article-title":"Plasmodium knowlesi malaria in humans is widely distributed and potentially life threatening","volume":"46","author":"Cox-Singh","year":"2008","journal-title":"Clin Infect Dis"},{"key":"2020081004182297600_CIT0016","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/nrmicro.2016.79","article-title":"Plasmodium species: master renovators of their host cells","volume":"14","author":"de Koning-Ward","year":"2016","journal-title":"Nat Rev Microbiol"},{"key":"2020081004182297600_CIT0017","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.pt.2004.07.004","article-title":"Why do we need to know more about mixed Plasmodium species infections in humans?","volume":"20","author":"Zimmerman","year":"2004","journal-title":"Trends Parasitol"},{"key":"2020081004182297600_CIT0018","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.tracli.2006.11.005","article-title":"Mechanisms of transfusion-linked parasite infection","volume":"13","author":"Garraud","year":"2006","journal-title":"Transfus Clin Biol"},{"key":"2020081004182297600_CIT0019","doi-asserted-by":"crossref","first-page":"1\u20139","DOI":"10.1186\/2046-4053-4-1","article-title":"Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) 2015 statement","volume":"4","author":"Moher","year":"2015","journal-title":"Syst Rev"},{"key":"2020081004182297600_CIT0020","doi-asserted-by":"crossref","first-page":"441\u2013448","DOI":"10.1186\/1471-2334-14-441","article-title":"High frequency of kdr L1014F is associated with pyrethroid resistance in Anopheles coluzzii in Sudan savannah of northern Nigeria","volume":"14","author":"Ibrahim","year":"2014","journal-title":"BMC Infect Dis"},{"key":"2020081004182297600_CIT0021","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1289\/ehp.0901256","article-title":"Modeling the effects of weather and climate change on malaria transmission","volume":"118","author":"Parham","year":"2010","journal-title":"Environ Health Perspect"},{"issue":"1","key":"2020081004182297600_CIT0022","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00285-017-1183-9","article-title":"A climate-based malaria model with the use of bed nets","volume":"77","author":"Wang","year":"2017","journal-title":"J Math Biol"},{"key":"2020081004182297600_CIT0023","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1778-428X.2004.tb00108.x","article-title":"Blood transfusion in Sub-Saharan Africa","volume":"6","author":"Allain","year":"2004","journal-title":"Transfus Altern Transfus Med"},{"key":"2020081004182297600_CIT0024","doi-asserted-by":"crossref","first-page":"548\u2013560","DOI":"10.1186\/s12936-016-1586-x","article-title":"Post-exposure serological responses to malaria parasites in potential blood donors","volume":"15","author":"Portugal-Calisto","year":"2016","journal-title":"Malar J"},{"key":"2020081004182297600_CIT0025","volume-title":"Blood Donor Selection: Guidelines on Assessing Donor Suitability for Blood Donation","author":"WHO","year":"2012"},{"key":"2020081004182297600_CIT0026","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/S1473-3099(06)70579-5","article-title":"The reliability of diagnostic techniques in the diagnosis and management of malaria in the absence of a gold standard","volume":"6","author":"Ochola","year":"2006","journal-title":"Lancet Infect Dis"},{"key":"2020081004182297600_CIT0027","doi-asserted-by":"crossref","first-page":"4072","DOI":"10.1128\/JCM.38.11.4072-4075.2000","article-title":"Detection and quantification of Plasmodium falciparum in blood samples using quantitative nucleic acid sequence-based amplification","volume":"38","author":"Schoone","year":"2000","journal-title":"J Clin Microbiol"},{"key":"2020081004182297600_CIT0028","doi-asserted-by":"crossref","first-page":"150","DOI":"10.4103\/0022-3859.183167","article-title":"Assessing the reliability of microscopy and rapid diagnostic tests in malaria diagnosis in areas with varying parasite density among older children and adult patients in Nigeria","volume":"62","author":"Ayogu","year":"2016","journal-title":"J Postgrad Med"},{"key":"2020081004182297600_CIT0029","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1080\/00034983.1995.11812994","article-title":"Asymptomatic malaria parasitaemia and seroreactivities to Plasmodium falciparum antigens in blood donors from Ibadan, south-western Nigeria","volume":"89","author":"Achidi","year":"1995","journal-title":"Ann Trop Med Parasitol"}],"container-title":["Open Forum Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ofid\/advance-article-pdf\/doi\/10.1093\/ofid\/ofz283\/28795326\/ofz283.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ofid\/article-pdf\/6\/7\/ofz283\/33589900\/ofz283.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ofid\/article-pdf\/6\/7\/ofz283\/33589900\/ofz283.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T04:26:30Z","timestamp":1597033590000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ofid\/article\/doi\/10.1093\/ofid\/ofz283\/5514070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,11]]},"references-count":29,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ofid\/ofz283","relation":{},"ISSN":["2328-8957"],"issn-type":[{"value":"2328-8957","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,7]]},"published":{"date-parts":[[2019,6,11]]},"article-number":"ofz283"}}