{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:26:20Z","timestamp":1777397180629,"version":"3.51.4"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T00:00:00Z","timestamp":1561075200000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We assessed the prevalence and risk factors of anal and oral high-risk (HR) human papillomavirus (HPV) infection in human immunodeficiency virus\u2013uninfected men who have sex with men (MSM) and take preexposure prophylaxis (PrEP) in France.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Anal and oral samples were screened by multiplex real-time polymerase chain reaction (Anyplex II HPV 28; Seegene) for HPV DNA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 61 unvaccinated MSM (mean age, 36.1 years) were enrolled. Anal HPV and HR-HPV prevalences were 93.4% and 81.9%, respectively, and oral HPV and HR-HPV prevalences, 33.9% and 19.6%, respectively. HR-HPV type 33 was the most detected genotype, in both anal and oral samples. Among MSM, 68.8% carried \u22651 anal HPV type targeted by the 9-valent Gardasil-9 vaccine; all oral HPV-positive samples carried \u22651 strain included in the vaccine. Condomless receptive anal intercourse and history of anal gonorrhea were the main factors associated with increased risk for anal HPV infection (adjusted odds ratio, 10.4) and anal infection with multiple HR-HPV genotypes (5.77), respectively. Conversely, having had &amp;lt;10 partners in the last 12 months was associated with decreased risk for anal carriage of both multiple HPV (adjusted odds ratio, 0.19) and HR-HPV (0.17) types.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>French MSM using PrEP are at high risk for both anal and oral carriage of HR-HPV that could lead to HPV-related cancers.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ofid\/ofz291","type":"journal-article","created":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T14:40:06Z","timestamp":1561128006000},"source":"Crossref","is-referenced-by-count":23,"title":["High Prevalence of Anal and Oral High-Risk Human Papillomavirus in Human Immunodeficiency Virus\u2013Uninfected French Men Who Have Sex With Men and Use Preexposure Prophylaxis"],"prefix":"10.1093","volume":"6","author":[{"given":"Ralph-Sydney","family":"Mboumba Bouassa","sequence":"first","affiliation":[{"name":"Laboratoire de Virologie, H\u00f4pital Europ\u00e9en Georges 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d\u2019Orl\u00e9ans, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Puech","sequence":"additional","affiliation":[{"name":"Laboratoire de Virologie, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique-H\u00f4pitaux de Paris and Universit\u00e9 Paris Descartes, Paris Sorbonne Cit\u00e9, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serge","family":"Tonen Wolyec","sequence":"additional","affiliation":[{"name":"Ecole Doctorale R\u00e9gionale en Infectiologie Tropicale, Franceville, Gabon"},{"name":"Facult\u00e9 de M\u00e9decine et de Pharmacie, Universit\u00e9 de Kisangani, Kisangani, Democratic Republic of the Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Veyer","sequence":"additional","affiliation":[{"name":"Laboratoire de Virologie, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique-H\u00f4pitaux de Paris and Universit\u00e9 Paris Descartes, Paris 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