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The patient recovered with acyclovir that was dose-adjusted for neurotoxicity and developed a vigorous anti-HSV-1 T-cell response.<\/jats:p>","DOI":"10.1093\/ofid\/ofz465","type":"journal-article","created":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T14:17:39Z","timestamp":1572963459000},"source":"Crossref","is-referenced-by-count":5,"title":["Trillions and Trillions: Herpes Simplex Virus\u20131 Hepatitis in an Immunocompetent Adult"],"prefix":"10.1093","volume":"6","author":[{"given":"Kevin","family":"Ikuta","sequence":"first","affiliation":[{"name":"Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavitra","family":"Roychoudhury","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, University of Washington, Seattle, Washington, 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric D","family":"Lamotte","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, Department of Medicine, University of Washington, Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Washington, Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Morris","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Washington, Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ba\u015fak","family":"\u04aaoruh","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, and Sleep 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Cancer Research Center Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajit P","family":"Limaye","sequence":"additional","affiliation":[{"name":"Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina M","family":"Lockwood","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M","family":"Holland","sequence":"additional","affiliation":[{"name":"Immunopathogenesis Section, National Institute of Allergy and Infectious Disease, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M","family":"Rakita","sequence":"additional","affiliation":[{"name":"Division of Allergy and Infectious Diseases, Department of Medicine, 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