{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:13:20Z","timestamp":1753877600332,"version":"3.41.2"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T00:00:00Z","timestamp":1606176000000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Congenital toxoplasmosis is an uncommon infection. Hypothalamic\/pituitary involvement leading to isolated central diabetes insipidus is extremely rare. Making a correct diagnosis of this condition, albeit challenging, is crucial for adequate management. We present a 54-year-old female who developed central diabetes insipidus as a complication of congenital toxoplasmosis. She had polydipsia and hypernatraemia on presentation and responded to intranasal desmopressin with normalization of above-mentioned findings. Magnetic resonance imaging and cranial X-ray\u2019s showed pronounced intracranial calcifications in both choroid plexuses. Thyroid function tests, serum cortisol level and anterior pituitary function were all normal. To the best of our knowledge, this is the first reported case of isolated diabetes insipidus due to congenital toxoplasmosis in literature diagnosed late in adulthood and gives an insight into the challenges of diagnosing central diabetes insipidus and the hypothalamic\/pituitary involvement in cases of congenital toxoplasmosis.<\/jats:p>","DOI":"10.1093\/omcr\/omaa105","type":"journal-article","created":{"date-parts":[[2020,12,7]],"date-time":"2020-12-07T04:27:21Z","timestamp":1607315241000},"source":"Crossref","is-referenced-by-count":0,"title":["Late diagnosis of isolated central diabetes insipidus secondary to congenital toxoplasmosis\u2014case report"],"prefix":"10.1093","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1832-6204","authenticated-orcid":false,"given":"Tahir","family":"Omer","sequence":"first","affiliation":[{"name":"Department of Clinical sciences and nutrition, University of Chester, Chester, UK"},{"name":"Department of Life Sciences and Education, University of South Wales, Cardiff, UK"},{"name":"Department of Endocrinology and Diabetes, Northampton General Hospital, Northampton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes, Bedford Hospital, Bedford, UK"},{"name":"Department of Biomedical and Life Sciences, Cardiff University, Cardiff, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Western","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Rotorua Hospital, Rotorua, New Zealand"},{"name":"Department of Endocrinology and Diabetes, Bedford Hospital, Bedford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,11,24]]},"reference":[{"key":"2020120621152817100_ref1","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1128\/CMR.05013-11","article-title":"Epidemiology of and diagnostic strategies for toxoplasmosis","volume":"25","author":"Robert-Gangneux","year":"2012","journal-title":"Clin Microbiol Rev"},{"key":"2020120621152817100_ref2","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1186\/1756-0500-7-184","article-title":"Congenital toxoplasmosis presenting as central diabetes insipidus in an infant: a case report","volume":"7","author":"Mohamed","year":"2014","journal-title":"BMC Res Notes"},{"key":"2020120621152817100_ref3","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.jpeds.2005.05.030","article-title":"Congenital toxoplasmosis complicated with central diabetes insipidus in the first week of life","volume":"148","author":"Nitta","year":"2006","journal-title":"J Pediatr"},{"key":"2020120621152817100_ref4","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/S0140-6736(07)60072-5","article-title":"Effectiveness of prenatal treatment for congenital toxoplasmosis","volume":"369","author":"Thiebaut","year":"2007","journal-title":"Lancet"},{"key":"2020120621152817100_ref5","first-page":"205","volume-title":"Toxoplasmosis","author":"Remington","year":"2001","edition":"4th"},{"key":"2020120621152817100_ref6","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1055\/s-2007-993924","article-title":"Central diabetes insipidus in a patient with congenital toxoplasmosis","volume":"15","author":"Oyg\u00fcr","year":"1998","journal-title":"Am J Perinatol"},{"key":"2020120621152817100_ref7","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1515\/JPEM.2006.19.2.173","article-title":"Isolated central diabetes insipidus in a newborn with congenital toxoplasmosis","volume":"19","author":"Karadag","year":"2006","journal-title":"J Pediar Endocrinol Metab"},{"key":"2020120621152817100_ref8","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1159\/000336333","article-title":"Diabetes insipidus; 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