{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T18:01:22Z","timestamp":1769882482615,"version":"3.49.0"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T00:00:00Z","timestamp":1610409600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Gorham-Stout disease (GSD) is a rare entity that destroys the bone matrix resulting mainly in osteolysis, pain and pathologic fractures among a broader clinical picture. We report a case of a 60-year-old female with a sudden discovery of pathologic fractures in the pelvis and the absence of the left femoral head. On biopsy, no cellular atypia was found, instead disturbed bone formation with prominent vascularity with scattered foci of necrosis &amp; osteolysis, which lead to the diagnosis of GSD. Possible differential diagnoses were discussed and excluded. The patient was put on Bisphosphonate that led to a relative improvement in the symptoms. This disease needs a more thorough investigation to identify the key cause, what is beyond the scope of this report.<\/jats:p>","DOI":"10.1093\/omcr\/omaa121","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T10:12:52Z","timestamp":1611915172000},"source":"Crossref","is-referenced-by-count":7,"title":["Gorham Stout disease: a case report from Syria"],"prefix":"10.1093","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2668-5517","authenticated-orcid":false,"given":"Asil","family":"Esper","sequence":"first","affiliation":[{"name":"Neurology Department, Tishreen University Hospital, Halap street, Latakia, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2646-3308","authenticated-orcid":false,"given":"Sami","family":"Alhoulaiby","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Damascus University, Damascus, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Areege","family":"Emran","sequence":"additional","affiliation":[{"name":"Pulmonary Department, Tishreen University Hospital, Latakia, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Safwan","family":"Youssef","sequence":"additional","affiliation":[{"name":"Orthopedics Department, Tishreen University Hospital, Latakia, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuheir","family":"Alshehabi","sequence":"additional","affiliation":[{"name":"Pathology Department, Tishreen University Hospital, Latakia, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,1,12]]},"reference":[{"key":"2021012910103949400_ref1","doi-asserted-by":"crossref","first-page":"694","DOI":"10.5312\/wjo.v5.i5.694","article-title":"Vanishing bone disease (Gorham-Stout syndrome): a review of a rare entity","volume":"5","author":"Nikolaou","year":"2014","journal-title":"World J Orthop"},{"key":"2021012910103949400_ref2","doi-asserted-by":"crossref","first-page":"227","DOI":"10.4103\/0973-1482.19592","article-title":"Vanishing bone disease involving the pelvis","volume":"1","author":"Malde","year":"2005","journal-title":"J Cancer Res Ther"},{"key":"2021012910103949400_ref3","doi-asserted-by":"crossref","first-page":"180","DOI":"10.4103\/0970-4388.180450","article-title":"Gorham\u2019s disease of mandible--a rare case presentation in pediatric patient","volume":"34","author":"Mukhopadhyay","year":"2016","journal-title":"J Indian Soc Pedod Prev Dent"},{"key":"2021012910103949400_ref4","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.bone.2014.02.011","article-title":"Viewpoints on vessels and vanishing bones in Gorham-stout disease","volume":"63","author":"Dellinger","year":"2014","journal-title":"Bone"},{"key":"2021012910103949400_ref5","article-title":"Bone densitometry [internet]","author":"University of Washington","year":"2011"},{"key":"2021012910103949400_ref6","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.joms.2010.05.088","article-title":"Vanishing bone disease: a review","volume":"69","author":"Kiran","year":"2011","journal-title":"J Oral Maxillofac Surg"},{"key":"2021012910103949400_ref7","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0030-4220(83)90185-8","article-title":"Perspectives on massive osteolysis. Report of a case and review of the literature","volume":"55","author":"Heffez","year":"1983","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"2021012910103949400_ref8","author":"ISSVA"},{"key":"2021012910103949400_ref9","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1089\/wound.2018.0850","article-title":"Generalized lymphatic anomaly and Gorham-Stout disease: overview and recent insights","volume":"8","author":"Ozeki","year":"2019","journal-title":"Adv Wound Care (New Rochelle)"},{"key":"2021012910103949400_ref10","article-title":"Clinical manifestations, diagnosis, and evaluation of osteoporosis in postmenopausal women [internet]","author":"Rosen","journal-title":"UpToDate"}],"container-title":["Oxford Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/omcr\/article-pdf\/2021\/1\/omaa121\/36126420\/omaa121.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/omcr\/article-pdf\/2021\/1\/omaa121\/36126420\/omaa121.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T10:12:55Z","timestamp":1611915175000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/omcr\/article\/doi\/10.1093\/omcr\/omaa121\/6086826"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/omcr\/omaa121","relation":{},"ISSN":["2053-8855"],"issn-type":[{"value":"2053-8855","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,1]]},"published":{"date-parts":[[2021,1,1]]},"article-number":"omaa121"}}