{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:13:21Z","timestamp":1753877601708,"version":"3.41.2"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T00:00:00Z","timestamp":1611878400000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Azithromycin and chloroquine\/hydroxychloroquine are being used internationally off-label to treat patients with coronavirus disease 2019 (COVID-19) based on in vitro and weak studies involving humans. However, the evidence about the benefit of these drugs is very uncertain and on the other hand, information regarding possible harms is on the rise. There are increasing reports associating chloroquine\/hydroxychloroquine with\/without azithromycin with prolonged QT and ventricular arrhythmias (monomorphic or polymorphic ventricular tachycardia) in COVID-19 patients. We present the case of a severe acute respiratory syndrome coronavirus 2-infected kidney transplant patient for which he received treatment with chloroquine plus azithromycin and on Day 4 of therapy, the patient suddenly developed a wide complex tachycardia. Because of the increasing reports of adverse effects related to these drugs, their use should be avoided until further evidence of clinical benefit is available.<\/jats:p>","DOI":"10.1093\/omcr\/omaa124","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T10:11:41Z","timestamp":1611915101000},"source":"Crossref","is-referenced-by-count":1,"title":["Wide complex tachycardia in a patient with COVID-19 treated with chloroquine\/azithromycin"],"prefix":"10.1093","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1842-2554","authenticated-orcid":false,"given":"Abraham Edgar","family":"Gracia-Ramos","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, General Hospital, National Medical Center \u201cLa Raza\u201d, Instituto Mexicano del Seguro Social, Mexico City, Mexico"},{"name":"Department of Internal Medicine, Hospital Regional de Alta Especialidad de Zumpango, Estado de Mexico, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Cortes-Ortiz","sequence":"additional","affiliation":[{"name":"Cardiology Service, Hospital Regional de Alta Especialidad de Zumpango, Estado de Mexico, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,1,23]]},"reference":[{"key":"2021012910101231200_ref1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.6019","article-title":"Pharmacologic treatments for coronavirus disease 2019 (COVID-19): a review","author":"Sanders","year":"2020","journal-title":"JAMA"},{"key":"2021012910101231200_ref2","doi-asserted-by":"crossref","DOI":"10.1016\/j.hrthm.2020.05.008","article-title":"QT prolongation, torsades de pointes and sudden death with short courses of chloroquine or hydroxychloroquine as used in COVID-19: a systematic review","author":"Jankelson","year":"2020","journal-title":"Heart Rhythm."},{"author":"World Health 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hydroxychloroquine\/azithromycin","author":"Chorin","year":"2020","journal-title":"Heart Rhythm"},{"key":"2021012910101231200_ref7","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1111\/j.1553-2712.2001.tb01275.x","article-title":"Meta-analysis of the risk of Torsades de pointes in patients treated with intravenous racemic sotalol","volume":"8","author":"Marill","year":"2001","journal-title":"Acad Emerg Med"},{"key":"2021012910101231200_ref8","doi-asserted-by":"publisher","first-page":"e208857","DOI":"10.1001\/jamanetworkopen.2020.8857","article-title":"Effect of high vs low doses of chloroquine diphosphate as adjunctive therapy for patients hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: a randomized clinical trial","volume":"3","author":"Borba","year":"2020","journal-title":"JAMA Netw 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