{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:13:24Z","timestamp":1753877604639,"version":"3.41.2"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T00:00:00Z","timestamp":1615161600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Narcotic bowel syndrome is defined as worsening abdominal bloating and cramping with chronic opiate use, leading to paralytic ileus. This syndrome is common yet underreported in adults. However, there is no current evidence of such conditions in the newborn after exposure in utero to high doses of opiates. Our patient was a female indigenous preterm infant born to a mother on a high dose of methadone. On admission at the age of 12\u00a0h, she was found to have significant gastric distension. Initial abdominal X-ray showed a large gastric bubble with little evidence of rectal gas. Malrotation was suspected and surgical intervention was discussed. However, repeat abdominal X-ray, ultrasound and upper Gastrointestinal series were found to be normal and without acute findings. Thus, surgery was avoided. The gastric distension resolved spontaneously. She never required opiate therapy for neonatal abstinence syndrome. Given the pattern of gas seen on the initial abdominal X-ray and its spontaneous resolution after removal of maternal methadone, we suspect this baby had neonatal narcotic bowel syndrome. This has never been reported in the literature and is a unique finding. Given the lack of current reports, further observations for this syndrome should be conducted.<\/jats:p>","DOI":"10.1093\/omcr\/omab004","type":"journal-article","created":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T06:31:28Z","timestamp":1615444288000},"source":"Crossref","is-referenced-by-count":2,"title":["Paralytic ileus in the neonate as a rare complication of maternal methadone treatment\u2014a case report"],"prefix":"10.1093","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4712-1929","authenticated-orcid":false,"given":"Joshua D","family":"Emery","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7697-0893","authenticated-orcid":false,"given":"Veronica M","family":"Samedi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Neonatal Intensive Care Unit, Royal University Hospital, University of Saskatchewan, 103 Hospital Dr, Saskatoon, Saskatchewan, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William T","family":"Bingham","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Neonatal Intensive Care Unit, Royal University Hospital, University of Saskatchewan, 103 Hospital Dr, Saskatoon, Saskatchewan, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,3,8]]},"reference":[{"key":"2021031106181799800_ref1","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/S2468-1253(18)30008-6","article-title":"Pathophysiology, diagnosis, and management of opioid-induced constipation","volume":"3","author":"Farmer","year":"2018","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"2021031106181799800_ref2","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1016\/S0002-9610(01)00782-6","article-title":"Incidence, prevalence, and management of opioid bowel dysfunction","volume":"182","author":"Pappagallo","year":"2001","journal-title":"Am J Surg"},{"key":"2021031106181799800_ref3","doi-asserted-by":"crossref","first-page":"47","DOI":"10.5055\/jom.2009.0006","article-title":"The opioid exposed newborn: assessment and pharmacological management","volume":"5","author":"Jansson","year":"2009","journal-title":"J Opioid Manag"},{"key":"2021031106181799800_ref4","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1093\/bjaceaccp\/mku013","article-title":"Placental structure, function and drug transfer","volume":"15","author":"Griffiths","year":"2015","journal-title":"Contin Educ Anaesth Crit Care Pain"},{"key":"2021031106181799800_ref5","doi-asserted-by":"crossref","DOI":"10.5935\/MedicalExpress.2015.01.03","article-title":"Clinical pharmacology of methadone in neonates and in their mothers. 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