{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:04:09Z","timestamp":1753877049724,"version":"3.41.2"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T00:00:00Z","timestamp":1621900800000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>The favorable impact of antiviral therapy on low-grade hepatitis C virus (HCV)-related non-Hodgkin lymphoma manifesting as marginal zone lymphoma (MZL) has been reported in some clinical studies. However, primary HCV-related marginal zone lymphomas (MZLs) confined to the liver have not been described in the literature nor have the resolution of liver lymphoma through anti-HCV eradication treatment. The authors report a genotype 1b HCV-positive patient with chronic hepatitis who exhibited lesions involving both hepatic lobes resembling hepatocellular carcinoma. Liver biopsy revealed an MZL of the liver. Antiviral treatment using sofosbuvir associated with simeprevir as unique treatment was started and resulted in complete haematological response. In HCV-related MZL isolated to the liver, antiviral treatment has led to the eradication of viral infection and a complete haematological response. Antiviral therapy should be considered as a first-line treatment for HCV-related primary MZLs of the liver.<\/jats:p>","DOI":"10.1093\/omcr\/omab022","type":"journal-article","created":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T13:59:55Z","timestamp":1622037595000},"source":"Crossref","is-referenced-by-count":0,"title":["Resolution of primary hepatic marginal zone lymphoma in a hepatitis C virus-infected patient treated with a direct-acting antiviral"],"prefix":"10.1093","volume":"2021","author":[{"given":"Adriano","family":"Pellicelli","sequence":"first","affiliation":[{"name":"Liver Unit, Department of Liver Transplant, Azienda Ospedaliera San Camillo Forlanini, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerio","family":"Giannelli","sequence":"additional","affiliation":[{"name":"Liver Unit, Department of Liver Transplant, Azienda Ospedaliera San Camillo Forlanini, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerio","family":"Zoli","sequence":"additional","affiliation":[{"name":"Hematology Unit, Azienda Ospedaliera San Camillo Forlanini, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Regine","sequence":"additional","affiliation":[{"name":"Department of Radiology, Azienda Ospedaliera San Camillo Forlanini, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Cortese","sequence":"additional","affiliation":[{"name":"Department of Radiology, Azienda Ospedaliera San Camillo Forlanini, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe M","family":"Ettorre","sequence":"additional","affiliation":[{"name":"Division of General Surgery and Liver Transplantation, Azienda Ospedaliera San Camillo Forlanini, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Carmenini","sequence":"additional","affiliation":[{"name":"Liver Unit, Department of Liver Transplant, Azienda Ospedaliera San Camillo Forlanini, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Pellicelli","sequence":"additional","affiliation":[{"name":"Internal Medicine, Azienda Ospedaliera Sant\u2019Andrea Universit\u00e0 degli Studi \u201cLa Sapienza\u201d, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Rigacci","sequence":"additional","affiliation":[{"name":"Hematology Unit, Azienda Ospedaliera San Camillo Forlanini, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,5,24]]},"reference":[{"key":"2021070812425269700_ref1","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.cgh.2008.02.011","article-title":"Hepatitis C and non-Hodgkin lymphoma among 4784 cases and 6269 controls from the g international lymphoma epidemiology consortium","volume":"6","author":"Sanjose","year":"2008","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2021070812425269700_ref2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1056\/NEJMoa013376","article-title":"Regression of splenic lymphoma with villous lymphocytes after treatment of hepatitis C virus infection","volume":"347","author":"Hermine","year":"2002","journal-title":"New Engl J Med"},{"key":"2021070812425269700_ref3","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1111\/jvh.12518","article-title":"The anti lymphoma activity of antiviral therapy in HCV associated B-cell non-Hodgkin lymphomas: a meta analysis","volume":"23","author":"Peveling-Oberhag","year":"2016","journal-title":"J Viral Hepat"},{"key":"2021070812425269700_ref4","doi-asserted-by":"crossref","first-page":"73","DOI":"10.20517\/2394-5079.2017.02","article-title":"Primary hepatic lymphoma: is it a disease antity?","volume":"3","author":"Xiong","year":"2017","journal-title":"Hepatoma Res"},{"key":"2021070812425269700_ref5","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1053\/j.seminhematol.2018.05.007","article-title":"Diagnosis and classification of lymphoma: impact of technical advances","volume":"56","author":"Jaffe","year":"2019","journal-title":"Semin Hematol"},{"key":"2021070812425269700_ref6","doi-asserted-by":"crossref","first-page":"107","DOI":"10.4254\/wjh.v8.i2.107","article-title":"Hepatitis C virus and non-Hodgkin\u2019s lymphomas: meta-analysis of epidemiology data and therapy options","volume":"8","author":"Pozzato","year":"2016","journal-title":"World J Hepatol"},{"author":"NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines)","key":"2021070812425269700_ref7"},{"key":"2021070812425269700_ref8","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1002\/hep.24641","article-title":"An update on treatment of genotype 1 chronic hepatitis C virus infection: 2011 practice guideline by the American Association for the study of liver diseases","volume":"54","author":"Ghany","year":"2011","journal-title":"Hepatology"},{"key":"2021070812425269700_ref9","first-page":"6016","article-title":"Diagnosis and surgical treatment of primary hepatic lymphoma","volume":"16","author":"Yang","year":"2010","journal-title":"World J Gastroenterol"},{"key":"2021070812425269700_ref10","first-page":"250","article-title":"Primary hepatic marginal zone lymphoma in a patient with chronic hepatitis C","volume":"11","author":"Gherlan","year":"2016","journal-title":"Maedica"}],"container-title":["Oxford Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/omcr\/article-pdf\/2021\/5\/omab022\/38164108\/omab022.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/omcr\/article-pdf\/2021\/5\/omab022\/38164108\/omab022.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T21:32:54Z","timestamp":1625779974000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/omcr\/article\/doi\/10.1093\/omcr\/omab022\/6282886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,1]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5,1]]}},"URL":"https:\/\/doi.org\/10.1093\/omcr\/omab022","relation":{},"ISSN":["2053-8855"],"issn-type":[{"type":"electronic","value":"2053-8855"}],"subject":[],"published-other":{"date-parts":[[2021,5]]},"published":{"date-parts":[[2021,5,1]]},"article-number":"omab022"}}