{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:30:54Z","timestamp":1787009454783,"version":"build-2736575974"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T00:00:00Z","timestamp":1623974400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Varicella-zoster virus (VZV) reactivation causes a relatively common disease in immunocompromised patients characterized by rash and radiating pain. Aseptic meningitis is a rare complication of VZV infection and commonly is associated with exanthem and neurological signs. We present an atypical case of VZV meningitis in a healthy 56-year-old male who was initially presented with persistent headache as the only symptom. Anti-VZV immunoglobulin G titer both in serum and in cerebrospinal fluid (CSF) and the polymerase chain reaction (PCR) CSF analysis revealed VZV infection. Our case highlights the importance of considering VZV aseptic meningitis in immunocompetent individuals even in the absence of the typical presentation of meningitis. Screening techniques such as CSF, PCR as well as anti-VZV antibodies in CSF show that VZV meningitis is a common cause of aseptic meningitis and allows the early recognition of CNS involvement in the VZV infection.<\/jats:p>","DOI":"10.1093\/omcr\/omab035","type":"journal-article","created":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T08:00:04Z","timestamp":1624003204000},"source":"Crossref","is-referenced-by-count":7,"title":["Varicella-zoster virus aseptic meningitis: an atypical presentation in an immunocompetent male patient"],"prefix":"10.1093","volume":"2021","author":[{"given":"Christina","family":"Platanaki","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University General Hospital of Patras, Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonidia","family":"Leonidou","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University General Hospital of Patras, Patras, Greece"},{"name":"Department of Internal Medicine, Division of Infectious Diseases, University General Hospital of Patras, Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Siagkris","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University General Hospital of Patras, Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0399oanna","family":"Giannopoulou","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University General Hospital of Patras, Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fotini","family":"Paliogianni","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University General Hospital of Patras, Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Velissaris","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University General Hospital of Patras, Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,6,18]]},"reference":[{"key":"2021070812425778100_ref1","volume-title":"Aseptic Meningitis in Adults","author":"Tunkel"},{"key":"2021070812425778100_ref2","doi-asserted-by":"publisher","first-page":"e529","DOI":"10.1016\/j.ijid.2013.01.031 Dis","article-title":"Infection of the central nervous system caused by varicella zoster virus reactivation: a retrospective case series study","volume":"17","author":"Becerra","year":"2013","journal-title":"Int J Infect Dis"},{"key":"2021070812425778100_ref3","doi-asserted-by":"publisher","first-page":"701","DOI":"10.12659\/AJCR.915300","article-title":"Varicella zoster meningitis with Hypoglycorrhachia on cerebrospinal fluid (CSF) analysis in a young immunocompetent host without a rash","volume":"20","author":"Fadhel","year":"2019  16","journal-title":"Am J Case Rep"},{"key":"2021070812425778100_ref4","first-page":"103","article-title":"Diagnosis of varicella zoster virus meningitis-meningoencephalitis by the meningitis\/meningoencephalitis panel that detects DNA by PCR: a case series","volume":"1","author":"Galloza-Rivera","year":"2018","journal-title":"J Microbiol Lab Sci"},{"key":"2021070812425778100_ref5","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1056\/NEJM200003023420906","article-title":"Neurologic complications of the reactivation of varicella-zoster virus","volume":"342","author":"Gilden","year":"2000  2","journal-title":"N Engl J Med"},{"key":"2021070812425778100_ref6","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1001\/archneur.1989.00520390079020","article-title":"Varicella zoster-associated neurologic disease without skin lesions","volume":"46","author":"Mayo","year":"1989","journal-title":"Arch Neurol"},{"key":"2021070812425778100_ref7","doi-asserted-by":"publisher","first-page":"55","DOI":"10.3844\/ajidsp.2020.55.59","article-title":"Varicella zoster virus causing aseptic meningitis without fever or rash in an immunocompetent patient","volume":"16","author":"Raziq","year":"2020","journal-title":"Am J Infect Dis"},{"key":"2021070812425778100_ref8","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.idcr.2018.04.008","article-title":"Varicella-zoster virus meningitis with hypoglycorrhachia in a young immunocompetent adult without rash: a case report and literature review","volume":"12","author":"Spernovasilis","year":"2018  13","journal-title":"ID Cases"},{"key":"2021070812425778100_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2019.10.1520","article-title":"Varicella zoster meningitis with only headache","volume":"405","author":"Nam","year":"2019","journal-title":"J Neurol Sci"},{"key":"2021070812425778100_ref10","doi-asserted-by":"publisher","first-page":"168","DOI":"10.4103\/aian.AIAN_438_17","article-title":"Unusual presentation of varicella zoster virus meningitis - 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