{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:30:55Z","timestamp":1787009455250,"version":"build-2736575974"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T00:00:00Z","timestamp":1623974400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Anti-synthetase syndrome (ASS) is an autoimmune disease characterized by autoantibodies against an aminoacyl transfer RNA synthetase with clinical features including interstitial lung disease, non-erosive arthritis, myositis, Raynaud\u2019s phenomenon, unexplained fever and\/or mechanic\u2019s hands. Macrophage activation syndrome (MAS) is a potentially fatal hyper- inflammatory syndrome that can occur as a complication of systemic rheumatic diseases. However, the association of MAS and ASS has rarely been reported in the literature. Here, we report this association in a patient with overlap ASS and anti-CCP positive rheumatoid arthritis. First line management with steroids was complicated by diabetic ketoacidosis, hence requiring use of anti-IL1 therapy (anakinra) for disease control.<\/jats:p>","DOI":"10.1093\/omcr\/omab045","type":"journal-article","created":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T08:00:22Z","timestamp":1624003222000},"source":"Crossref","is-referenced-by-count":3,"title":["A case of macrophage activation syndrome in a patient with anti-synthetase syndrome"],"prefix":"10.1093","volume":"2021","author":[{"given":"Nadia","family":"Ahmad","sequence":"first","affiliation":[{"name":"Rheumatology, Royal Berkshire NHS Foundation Trust, Reading RG1 5AN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aneel","family":"Parmar","sequence":"additional","affiliation":[{"name":"Rheumatology, Royal Berkshire NHS Foundation Trust, Reading RG1 5AN, 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