{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:12:01Z","timestamp":1753877521937,"version":"3.41.2"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T00:00:00Z","timestamp":1623974400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Arrhythmogenic right ventricular cardiomyopathy (ARVC) is one of the leading causes of sudden cardiac death amongst young people and athletes. In this genetic disease, arrhythmia and fibro-fatty changes in the right ventricular myocardium are the main characteristics of the disease.<\/jats:p>\n               <jats:p>Here, we report a case of ARVC in a 12-year-old boy who was previously diagnosed with epilepsy, the patient\u2019s condition manifested sporadically and was complicated by rapid progression, and unfortunate fatal deterioration after admission into the pediatric emergency room due to fatigue, dizziness and palpitation.<\/jats:p>\n               <jats:p>A diagnosis of ARVC was established, even though a family history was absent. Due to possible rapid deterioration, as described in this case, we recommend immediate primary and secondary prevention of arrhythmias in these patients, and to take in consideration of the potential risks of using sodium valproate in these patients.<\/jats:p>","DOI":"10.1093\/omcr\/omab046","type":"journal-article","created":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T12:00:29Z","timestamp":1624017629000},"source":"Crossref","is-referenced-by-count":2,"title":["Sporadic and rapidly progressive arrhythmogenic right ventricular cardiomyopathy in a 12-year-old boy who was diagnosed with epilepsy"],"prefix":"10.1093","volume":"2021","author":[{"given":"Alaa","family":"Al-Khleaf","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Aleppo University Hospital and Aleppo University Hospital of Heart, University of Aleppo, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amal","family":"Babi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Aleppo University Hospital and Aleppo University Hospital of Heart, University of Aleppo, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mulham","family":"Jarjanazi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Aleppo, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walid","family":"Haddad","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Aleppo, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,6,18]]},"reference":[{"key":"2021070812425760900_ref1","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1161\/01.CIR.65.2.384","article-title":"Right ventricular dysplasia: a report of 24 adult 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Cardiol"},{"key":"2021070812425760900_ref5","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1161\/CIRCGENETICS.114.001003","article-title":"Clinical presentation, long-term follow-up, and outcomes of 1001 arrhythmogenic right ventricular dysplasia\/cardiomyopathy patients and family members","volume":"8","author":"Groeneweg","year":"2015","journal-title":"Circ Cardiovasc Genet"},{"key":"2021070812425760900_ref6","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.hrthm.2009.03.013","article-title":"Arrhythmogenic right ventricular cardiomyopathy\/dysplasia clinical presentation and diagnostic evaluation: results from the North American Multidisciplinary Study","volume":"6","author":"Marcus","year":"2009","journal-title":"Heart Rhythm"},{"key":"2021070812425760900_ref7","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1038\/ncpcardio1182","article-title":"Mechanisms of disease: molecular genetics of arrhythmogenic right ventricular dysplasia\/cardiomyopathy","volume":"5","author":"Awad","year":"2008","journal-title":"Nat Clin Pract Cardiovasc Med"},{"key":"2021070812425760900_ref8","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1093\/europace\/eun378","article-title":"Sporadic arrhythmogenic right ventricular cardiomyopathy\/dysplasia due to a de novo mutation","volume":"11","author":"Gandjbakhch","year":"2009","journal-title":"Europace"},{"key":"2021070812425760900_ref9","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1093\/eurheartj\/ehq025","article-title":"Diagnosis of arrhythmogenic right ventricular cardiomyopathy\/dysplasia proposed modification of the task force criteria","volume":"31","author":"Marcus","year":"2010","journal-title":"European heart journal"},{"volume-title":"Valproic Acid and Derivatives (Pediatric & Neonatal Lexi-Drugs) Hudson","year":"2015","author":"Online","key":"2021070812425760900_ref10"}],"container-title":["Oxford Medical Case 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