{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T16:08:27Z","timestamp":1791648507134,"version":"4.3.4"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T00:00:00Z","timestamp":1629072000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>A 7-week-old girl with a normal birth history suddenly developed respiratory distress while feeding. Cardiopulmonary resuscitation was initiated at home after she had a cardiac arrest and was continued in the emergency room but all efforts at resuscitation proved unsuccessful and she died 2 h after presentation. Investigations performed in the emergency room revealed that she had a significantly high white blood cell count and severe anaemia. The cause of death was identified as KMT2A-rearranged infantile acute lymphoblastic leukaemia based on cytogenetic tests. She had no abnormalities at the 4-week check-up; however, she developed a skin nodule on her abdomen thereafter, and the family did not consult a doctor for fear of contracting COVID-19. Early detection and diagnosis could have changed the prognosis of the patient. The present case highlights the negative impact of the reduction of outpatient consultations during the COVID-19 pandemic.<\/jats:p>","DOI":"10.1093\/omcr\/omab073","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T11:15:44Z","timestamp":1629112544000},"source":"Crossref","is-referenced-by-count":2,"title":["Sudden unexpected death caused by infantile acute lymphoblastic leukaemia"],"prefix":"10.1093","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2318-0406","authenticated-orcid":false,"given":"Kei","family":"Morota","sequence":"first","affiliation":[{"name":"Department of Paediatrics, Japanese Red Cross Maebashi Hospital, Gunma 371-0811, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5700-0250","authenticated-orcid":false,"given":"Mariko","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Japanese Red Cross Maebashi Hospital, Gunma 371-0811, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3593-0246","authenticated-orcid":false,"given":"Ryo","family":"Sugitate","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Japanese Red Cross Maebashi Hospital, Gunma 371-0811, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9629-1866","authenticated-orcid":false,"given":"Munenori","family":"Ide","sequence":"additional","affiliation":[{"name":"Department of Pathology, Japanese Red Cross Maebashi Hospital, Gunma 371-0811, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4000-0753","authenticated-orcid":false,"given":"Genki","family":"Yamato","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Gunma University, Gunma 371-8511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1520-7007","authenticated-orcid":false,"given":"Daisuke","family":"Tomizawa","sequence":"additional","affiliation":[{"name":"Division of Leukaemia and Lymphoma, Children\u2019s Cancer Centre, National Centre for Child Health and Development, Tokyo 157-0074, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9256-5591","authenticated-orcid":false,"given":"Kazuhiro","family":"Muramatsu","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Jichi Medical University, Tochigi 329-0498, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Matsui","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Japanese Red Cross Maebashi Hospital, Gunma 371-0811, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,8,13]]},"reference":[{"key":"2021081611104831300_ref1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1097\/01.paf.0000203267.91806.ed","article-title":"Sudden unexpected death in infancy and childhood due to undiagnosed neoplasia: an autopsy study","volume":"27","author":"Somers","year":"2006","journal-title":"Am J Forensic Med Pathol"},{"key":"2021081611104831300_ref2","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.26474","article-title":"Childhood neoplasms presenting at autopsy: a 20-year experience","volume":"64","author":"Bryant","year":"2017","journal-title":"Pediatr Blood Cancer"},{"key":"2021081611104831300_ref3","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1111\/ped.12758","article-title":"Recent peogress in the treatment of infant acute lymphoblastic leukemia","volume":"57","author":"Tomizawa","year":"2015","journal-title":"Pediatr Int"},{"key":"2021081611104831300_ref4","article-title":"Neonatal acute lymphocytic leukaemia: an unusual presentation of a rare disease","volume":"2015","author":"Palman","year":"2015","journal-title":"BMJ Case Rep"},{"key":"2021081611104831300_ref5","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1046\/j.1365-2141.2002.03459.x","article-title":"Congenital leukaemia: the Dutch experience and review of the literature","volume":"117","author":"Bresters","year":"2002","journal-title":"Br J Haematol"},{"key":"2021081611104831300_ref6","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.28427","article-title":"Delayed cancer diagnoses and high mortality in children during the COVID-19 pandemic","volume":"67","author":"Ding","year":"2020","journal-title":"Pediatr Blood Cancer"},{"key":"2021081611104831300_ref7","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.28482","article-title":"Collateral effects of COVID-19 pandemic in pediatric hematooncology: fatalities caused by diagnostic delay","volume":"67","author":"Parasole","year":"2020","journal-title":"Pediatr Blood Cancer"},{"key":"2021081611104831300_ref8","doi-asserted-by":"crossref","first-page":"e445","DOI":"10.1016\/S1470-2045(12)70361-3","article-title":"Delays in diagnosis of paediatric cancers: a systematic review and comparison with expert testimony in lawsuits","volume":"13","author":"Brasme","year":"2012","journal-title":"Lancet Oncol"},{"key":"2021081611104831300_ref9","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1182\/blood.2019004741","article-title":"A risk-stratified therapy for infants with acute lymphoblastic leukemia: a report from the JPLSG MLL-10 trial","volume":"136","author":"Tomizawa","year":"2020","journal-title":"Blood"}],"container-title":["Oxford Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/omcr\/article-pdf\/2021\/8\/omab073\/39718051\/omab073.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/omcr\/article-pdf\/2021\/8\/omab073\/39718051\/omab073.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T11:15:54Z","timestamp":1629112554000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/omcr\/article\/doi\/10.1093\/omcr\/omab073\/6350616"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,1]]},"references-count":9,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/omcr\/omab073","relation":{},"ISSN":["2053-8855"],"issn-type":[{"value":"2053-8855","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,8]]},"published":{"date-parts":[[2021,8,1]]},"article-number":"omab073"}}