{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T18:27:47Z","timestamp":1773685667755,"version":"3.50.1"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T00:00:00Z","timestamp":1635379200000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Office of the Dean for Research and Scholarship, College of Osteopathic Medicine, University of New England"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Sarcoidosis is a rare multisystem autoimmune disease characterized by the presence of non-caseating granulomas in involved organs. We report a novel case of a 61-year-old Caucasian male with sarcoidosis presenting with recurrent chylothorax and chylous ascites. Pleural and ascitic fluid analysis revealed high triglyceride levels, consistent with chylothorax and chylous ascites, respectively. Common etiologies of chylous fluid such as thoracic duct surgical trauma, malignancy and infection were all excluded. Sarcoidosis was confirmed by the presence of non-caseating granulomas on a mediastinal lymph node biopsy. Conservative treatment with low-fat diet, prednisone, octreotide and multiple thoracenteses failed to effectively resolve the chylothorax. Surgical interventions with pleurodesis and thoracic duct ligation were performed, leading to the complete resolution of the chylous effusion and ascites.<\/jats:p>","DOI":"10.1093\/omcr\/omab098","type":"journal-article","created":{"date-parts":[[2021,10,31]],"date-time":"2021-10-31T12:35:08Z","timestamp":1635683708000},"source":"Crossref","is-referenced-by-count":2,"title":["Sarcoidosis with secondary recurrent right-sided chylothorax and chylous ascites in a Caucasian male patient"],"prefix":"10.1093","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8533-8382","authenticated-orcid":false,"given":"Sujaay Hari","family":"Jagannathan","sequence":"first","affiliation":[{"name":"College of Osteopathic Medicine, University of New England, Biddeford, ME 04005, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5606-348X","authenticated-orcid":false,"given":"Caleb M","family":"Winn","sequence":"additional","affiliation":[{"name":"College of Osteopathic Medicine, University of New England, Biddeford, ME 04005, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7347-1354","authenticated-orcid":false,"given":"Arun P","family":"Nayar","sequence":"additional","affiliation":[{"name":"College of Osteopathic Medicine, University of New England, Biddeford, ME 04005, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghassan J","family":"Koussa","sequence":"additional","affiliation":[{"name":"Department of Pulmonology & Critical Care Medicine, St. Luke\u2019s Medical Center, Utica, NY 13502, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol A","family":"Brenner","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, College of Osteopathic Medicine, University of New England, Biddeford, ME 04005, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,10,26]]},"reference":[{"key":"2021103112302160300_ref1","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1513\/AnnalsATS.201511-760OC","article-title":"Sarcoidosis in America. Analysis based on health care use","volume":"13","author":"Baughman","year":"2016","journal-title":"Ann Am Thorac Soc"},{"key":"2021103112302160300_ref2","first-page":"358","article-title":"Clinical manifestations, diagnosis, and treatment of sarcoidosis","volume":"3","author":"Ungprasert","year":"2019","journal-title":"Mayo Clinic Proc: Innovations, Qual Outcomes"},{"key":"2021103112302160300_ref3","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1378\/chest.129.6.1599","article-title":"Pleural effusions in a series of 181 outpatients with sarcoidosis","volume":"129","author":"Huggins","year":"2006","journal-title":"Chest"},{"key":"2021103112302160300_ref4","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.rmed.2019.08.014","article-title":"Clinical approach and review of causes of a chylothorax","volume":"157","author":"Riley","year":"2019","journal-title":"Respir Med"},{"key":"2021103112302160300_ref5","doi-asserted-by":"crossref","first-page":"144","DOI":"10.3810\/hp.2009.12.268","article-title":"Successful treatment of chylous ascites secondary to sarcoidosis with methotrexate","volume":"37","author":"Mannam","year":"2009","journal-title":"Hosp Pract"},{"key":"2021103112302160300_ref6","doi-asserted-by":"crossref","first-page":"28300","DOI":"10.3402\/jchimp.v5.28300","article-title":"A case of chylothorax in a patient with sarcoidosis: a rare and potentially fatal complication","volume":"5","author":"Bhattarai","year":"2015","journal-title":"J Commun Hosp Internal Med Perspect"},{"key":"2021103112302160300_ref7","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1111\/apt.14284","article-title":"Review article: the diagnostic approach and current management of chylous ascites","volume":"46","author":"Lizaola","year":"2017","journal-title":"Aliment Pharmacol Ther"},{"key":"2021103112302160300_ref8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.rmed.2009.08.010","article-title":"Chylothorax: aetiology, diagnosis and therapeutic options","volume":"104","author":"Mcgrath","year":"2010","journal-title":"Respir Med"}],"container-title":["Oxford Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/omcr\/article-pdf\/2021\/10\/omab098\/40936488\/omab098.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/omcr\/article-pdf\/2021\/10\/omab098\/40936488\/omab098.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,31]],"date-time":"2021-10-31T12:35:17Z","timestamp":1635683717000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/omcr\/article\/doi\/10.1093\/omcr\/omab098\/6410409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,1]]},"references-count":8,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/omcr\/omab098","relation":{},"ISSN":["2053-8855"],"issn-type":[{"value":"2053-8855","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,10]]},"published":{"date-parts":[[2021,10,1]]},"article-number":"omab098"}}