{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T07:34:46Z","timestamp":1781163286778,"version":"3.54.1"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,2,20]],"date-time":"2022-02-20T00:00:00Z","timestamp":1645315200000},"content-version":"vor","delay-in-days":19,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Infusion route problems can have a significant impact on hemodynamics in children with severe heart failure. Here, we report the case of a 13-year-old girl with dilated cardiomyopathy. Her condition fluctuated due to frequent occlusion of the central venous catheter (CVC) route. However, a quick check revealed no apparent abnormalities in the CVC, infusion route, in-line filter or infusion pump. Scanning electron microscopy revealed that dobutamine and heparin had crystallized and that the in-line filter membrane was occluded. This case emphasizes the importance of proper infusion route management in pediatric patients with severe heart failure. Even drugs that are used daily may form microscopic crystals at several concentrations and administration rates. Without an in-line filter, microscopic particles are injected into the body, and there is no evidence that the injected crystals do not cause permanent damage.<\/jats:p>","DOI":"10.1093\/omcr\/omab134","type":"journal-article","created":{"date-parts":[[2022,2,20]],"date-time":"2022-02-20T07:08:28Z","timestamp":1645340908000},"source":"Crossref","is-referenced-by-count":5,"title":["A large amount of microscopic precipitates are inevitably injected during infusion therapy without an in-line filter"],"prefix":"10.1093","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2225-9788","authenticated-orcid":false,"given":"Shinya","family":"Shimoyama","sequence":"first","affiliation":[{"name":"Department of Pediatric Cardiology, Gunma Children\u2019s Medical Center, Shibukawa 377-8577, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Gunma Children\u2019s Medical Center, Shibukawa 377-8577, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syuhei","family":"Arai","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Gunma Children\u2019s Medical Center, Shibukawa 377-8577, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Asami","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Gunma Children\u2019s Medical Center, Shibukawa 377-8577, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimiko","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Gunma Children\u2019s Medical Center, Shibukawa 377-8577, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Gunma Children\u2019s Medical Center, Shibukawa 377-8577, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takumi","family":"Takizawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Graduate School of Medicine, Gunma University, Maebashi 371-8511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomio","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Gunma Children\u2019s Medical Center, Shibukawa 377-8577, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,2,19]]},"reference":[{"key":"2022022007082153100_ref1","doi-asserted-by":"crossref","first-page":"7714","DOI":"10.1038\/s41598-018-25602-6","article-title":"Effectiveness of in-line filters to completely remove particulate contamination during a pediatric multidrug infusion protocol","volume":"8","author":"Perez","year":"2018","journal-title":"Sci 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solutions","volume":"28","author":"Oie","year":"2005","journal-title":"Biol Pharm Bull"},{"key":"2022022007082153100_ref5","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s40635-018-0205-2","article-title":"Analysis of particulate exposure during continuous drug infusion in critically ill adult patients: a preliminary proof-of-concept in vitro study","volume":"6","author":"Benlabed","year":"2018","journal-title":"Intensive Care Med Exp"},{"key":"2022022007082153100_ref6","first-page":"1690","article-title":"Compatibility and stability of dobutamine hydrochloride with large-volume parenterals and selected additives","volume":"40","author":"Kirschenbaum","year":"1983","journal-title":"Am J Hosp Pharm"},{"key":"2022022007082153100_ref7","first-page":"2588","article-title":"Dobutamine-heparin mixture inadvisable","volume":"41","author":"Hasegawa","year":"1984","journal-title":"Am J Hosp 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catheters","volume":"75","author":"Nishikawa","year":"2010","journal-title":"J Hosp Infect"}],"container-title":["Oxford Medical Case 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