{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:12:13Z","timestamp":1753877533804,"version":"3.41.2"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T00:00:00Z","timestamp":1664236800000},"content-version":"vor","delay-in-days":26,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>We present a case of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) in a 56-year-old woman, who presented to our emergency department with a 7-day history of exertional dyspnoea. Due to profound haemodynamic compromise, pulmonary embolism (PE) was suspected, and the patient underwent emergency thrombolysis on admission. A subsequent computerized tomography pulmonary angiogram revealed extensive bilateral PE. Incidentally, a 1.3\u00a0cm lesion within the right upper lobe, associated with pleural tethering, was identified. Positron emission tomography computerized tomography and, subsequently, histopathology revealed this lesion to be primary DIPNECH, a rare pre-invasive hyperplasia of neuroendocrine cells. While studies are scarce and cohort numbers are low, somatostatin analogues and protein kinase inhibitors have been proven to reduce symptoms and increase progression-free survival in DIPNECH, respectively.<\/jats:p>","DOI":"10.1093\/omcr\/omac069","type":"journal-article","created":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T16:16:25Z","timestamp":1664295385000},"source":"Crossref","is-referenced-by-count":1,"title":["Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia presenting as a solitary lung nodule: a rare histopathological diagnosis"],"prefix":"10.1093","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1085-3846","authenticated-orcid":false,"given":"Natalie","family":"Simon","sequence":"first","affiliation":[{"name":"Cambridge University NHS Foundation Trust Department of Surgery, , Cambridgeshire, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mostafa","family":"Negmeldin","sequence":"additional","affiliation":[{"name":"Bedford Hospital NHS Foundation Trust Department of Respiratory Medicine, , Bedford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,9,26]]},"reference":[{"key":"2022092713210005300_ref1","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.2214\/AJR.19.22628","article-title":"Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: imaging and clinical features of a frequently delayed diagnosis","volume":"215","author":"Little","year":"2020","journal-title":"Am J Roentgenol"},{"key":"2022092713210005300_ref2","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1136\/thx.2006.063065","article-title":"Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: an under-recognised spectrum of 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syndrome","volume":"84","author":"Cameron","year":"2011","journal-title":"Br J Radiol"},{"key":"2022092713210005300_ref9","first-page":"19","article-title":"Pulmonary embolism as the presenting symptom and a confounder in ACTH-secreting bronchial carcinoid","volume":"2019","author":"Yang","year":"2019","journal-title":"Endocrinol Diabetes Metab Case Rep"},{"key":"2022092713210005300_ref10","first-page":"739427","article-title":"Fatal paraneoplastic embolisms in both circulations in a patient with poorly differentiated neuroendocrine tumour","volume":"2013","author":"Busch","year":"2013","journal-title":"Case Rep Vasc Med"},{"volume-title":"Lung Neuroendocrine (carcinoid) Tumors: Treatment and Prognosis","year":"2021","author":"Thomas","key":"2022092713210005300_ref11"}],"container-title":["Oxford Medical Case 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