{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T20:28:46Z","timestamp":1783715326875,"version":"3.55.0"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T00:00:00Z","timestamp":1664236800000},"content-version":"vor","delay-in-days":26,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Scrub typhus is a mite borne zoonosis, caused by Orientia tsutsugamushi, a gram-negative intracellular organism. This infection usually presents in high prevalence in the rural areas of East Asia and Western pacific islands. It usually presents with fever, chill, myalgia, headache, skin rashes, having pathognomonic and skin lesion i.e. eschar in ~10% cases in Indian subcontinent. It can present with life-threatening complications on occasional. The simultaneous presentation of more than two complications is uncommon, rarely reported in literature. Here we report a case of 37-year-old woman with acute febrile illness, complicated with myocarditis, acute liver failure and leukemoid reaction. She was diagnosed promptly and successfully treated with doxycycline with full recovery of the complications.<\/jats:p>","DOI":"10.1093\/omcr\/omac092","type":"journal-article","created":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T16:16:30Z","timestamp":1664295390000},"source":"Crossref","is-referenced-by-count":4,"title":["A rare presentation of scrub typhus: myocarditis, acute liver failure and leukemoid reaction"],"prefix":"10.1093","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0741-3679","authenticated-orcid":false,"given":"Md Karimulla","family":"Mondal","sequence":"first","affiliation":[{"name":"IPGMER & SSKM Hospital Department of Internal Medicine, , Kolkata 700020, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayaditya","family":"Ghosh","sequence":"additional","affiliation":[{"name":"IPGMER & SSKM Hospital Department of Internal Medicine, , Kolkata 700020, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhaswar","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"IPGMER & SSKM Hospital Department of Internal Medicine, , Kolkata 700020, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nandini","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"IPGMER & SSKM Hospital Department of Internal Medicine, , Kolkata 700020, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumitra","family":"Ghosh","sequence":"additional","affiliation":[{"name":"IPGMER & SSKM Hospital Department of Internal Medicine, , Kolkata 700020, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,9,26]]},"reference":[{"key":"2022092713210535700_ref1","first-page":"70","article-title":"Recent advances in understanding pathophysiology of scrub typhus","volume":"12","author":"Dogra","year":"2010","journal-title":"JK Sci"},{"key":"2022092713210535700_ref2","first-page":"8","article-title":"A systematic review of mortality from untreated scrub typhus (Orientia tsutsugamushi)","volume":"9","author":"Taylor","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"key":"2022092713210535700_ref3","article-title":"Scrub typhus leading to acute liver failure in a pregnant patient","volume":"12","author":"Gaba","year":"2020","journal-title":"Cureus"},{"key":"2022092713210535700_ref4","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/modpathol.3880385","article-title":"Identification of the target cells of Orientia tsutsugamushi in human cases of scrub typhus","volume":"14","author":"Moron","year":"2001","journal-title":"Modern Pathol"},{"key":"2022092713210535700_ref5","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.jiph.2015.05.012","article-title":"Hemophagocytic lymphohistiocytosis with a leukemoid reaction in an infant with scrub typhus","volume":"8","author":"Pazhaniyandi","journal-title":"J Infect Public Health"},{"key":"2022092713210535700_ref6","volume-title":"Leucocytosis. Emedicine","author":"Innoue","year":"2014"},{"key":"2022092713210535700_ref7","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/ajh.2830040312","article-title":"Leukocyte alkaline phosphatase","volume":"4","author":"Okun","year":"1978","journal-title":"Am J Hematol"},{"key":"2022092713210535700_ref8","doi-asserted-by":"crossref","first-page":"3259","DOI":"10.1128\/AAC.00508-07","article-title":"Doxycycline versus azithromycin for treatment of leptospirosis and scrub typhus","volume":"51","author":"Phimda","year":"2007","journal-title":"Antimicrob Agents Chemother"}],"container-title":["Oxford Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2022\/9\/omac092\/46043960\/omac092.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2022\/9\/omac092\/46043960\/omac092.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T16:16:42Z","timestamp":1664295402000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/omcr\/article\/doi\/10.1093\/omcr\/omac092\/6717645"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,1]]},"references-count":8,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/omcr\/omac092","relation":{},"ISSN":["2053-8855"],"issn-type":[{"value":"2053-8855","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,9]]},"published":{"date-parts":[[2022,9,1]]},"article-number":"omac092"}}