{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:13:46Z","timestamp":1753877626824,"version":"3.41.2"},"reference-count":6,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T00:00:00Z","timestamp":1664236800000},"content-version":"vor","delay-in-days":26,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Multiple endocrine neoplasia type 1 (MEN 1) syndrome is a rare autosomal dominant endocrine tumour syndrome, which can be diagnosed clinically based on family history and the existence of MEN 1-associated tumours or molecularly based on genetic testing. We described the case of a Hispanic 55-year-old male presenting with dysphagia, chest pain and diarrhoea for three months with a family history of hypercalcaemia and nephrolithiasis in first-degree relatives. Primary hyperparathyroidism was suggested by hypercalcaemia, elevated parathyroid hormone level, hypercalciuria, nephrolithiasis on abdominal computed tomography scan and enlarged parathyroid gland on computed tomography pulmonary angiogram. Also, patient had hypergastrinemia and a hypodense lesion in the pancreas on computed tomography scan of abdomen. These findings suggested MEN 1 syndrome with high suspicion of associated Zollinger Ellison syndrome. Our case highlights the importance of family history and high clinical suspicion in patients presenting with primary hyperparathyroidism and hypergastrinemia.<\/jats:p>","DOI":"10.1093\/omcr\/omac094","type":"journal-article","created":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T16:16:47Z","timestamp":1664295407000},"source":"Crossref","is-referenced-by-count":1,"title":["Multiple endocrine neoplasia type 1 with suspicion of Zollinger Ellison syndrome in a family with history of renal stones and hypercalcemia in a limited resource setting: a case report"],"prefix":"10.1093","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9771-0970","authenticated-orcid":false,"given":"Kamran","family":"Hussain","sequence":"first","affiliation":[{"name":"Jamaica Hospital Medical Center Department of Internal Medicine, , New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jebun","family":"Nahar","sequence":"additional","affiliation":[{"name":"Jamaica Hospital Medical Center Department of Internal Medicine, , New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fakhar","family":"Abbas","sequence":"additional","affiliation":[{"name":"Jamaica Hospital Medical Center Department of Internal Medicine, , New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasir","family":"Nawar","sequence":"additional","affiliation":[{"name":"Bronx High School of Science , New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0279-4636","authenticated-orcid":false,"given":"Ayush","family":"Anand","sequence":"additional","affiliation":[{"name":"B. P. Koirala Institute of Health Sciences , Dharan, Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,9,26]]},"reference":[{"key":"2022092713211006100_ref1","article-title":"Diffuse hormonal systems and endocrine tumor syndromes","author":"Pieterman","year":"2021","journal-title":"Endotext"},{"key":"2022092713211006100_ref2","doi-asserted-by":"crossref","first-page":"2990","DOI":"10.1210\/jc.2012-1230","article-title":"Clinical practice guidelines for multiple endocrine neoplasia type 1 (MEN1)","volume":"97","author":"Thakker","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"2022092713211006100_ref3","article-title":"Multiple endocrine neoplasia type 1","author":"Giusti","year":"2022","journal-title":"GeneReviews"},{"key":"2022092713211006100_ref4","doi-asserted-by":"crossref","first-page":"204062232110352","DOI":"10.1177\/20406223211035288","article-title":"Multiple endocrine neoplasia 1: a broad overview","volume":"12","author":"Thompson","year":"2021","journal-title":"Therapeutic Advances in Chronic Disease"},{"key":"2022092713211006100_ref5","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ando.2021.03.005","article-title":"New therapies for patients with multiple endocrine neoplasia type 1","volume":"82","author":"Geslot","year":"2021","journal-title":"Ann Endocrinol"},{"key":"2022092713211006100_ref6","first-page":"1","article-title":"Update on the clinical management of multiple endocrine neoplasia type 1","author":"Pieterman","year":"2022","journal-title":"Clin Endocrinol"}],"container-title":["Oxford Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2022\/9\/omac094\/46043982\/omac094.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2022\/9\/omac094\/46043982\/omac094.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T16:16:54Z","timestamp":1664295414000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/omcr\/article\/doi\/10.1093\/omcr\/omac094\/6717649"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,1]]},"references-count":6,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/omcr\/omac094","relation":{},"ISSN":["2053-8855"],"issn-type":[{"type":"electronic","value":"2053-8855"}],"subject":[],"published-other":{"date-parts":[[2022,9]]},"published":{"date-parts":[[2022,9,1]]},"article-number":"omac094"}}