{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:12:15Z","timestamp":1753877535626,"version":"3.41.2"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T00:00:00Z","timestamp":1666569600000},"content-version":"vor","delay-in-days":23,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>We report a novel and as yet undescribed clinical scenario in a young girl with liver failure, in whom, the liver histopathology was suggestive of alcoholic hepatitis in the background of hepatoportal sclerosis and incomplete septal cirrhosis. An extensive clinical and investigational evaluation revealed chronic consumption of multiple Ayurvedic herbal medications for seizure disease. Six months after stopping herbal medicines, the repeat liver biopsy demonstrated resolution of alcohol-related changes but persistence of classical features of non-cirrhotic portal hypertension. Analysis of the retrieved agents, including state of the art chemical and toxicology analysis, using gas chromatography and mass spectroscopy methods demonstrated multiple organic and inorganic toxins associated with acute alcohol and arsenic poisoning related hepatoportal sclerosis\/incomplete septal cirrhosis in the young girl.<\/jats:p>","DOI":"10.1093\/omcr\/omac113","type":"journal-article","created":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T09:07:41Z","timestamp":1666602461000},"source":"Crossref","is-referenced-by-count":3,"title":["Ayurvedic treatment induced severe alcoholic hepatitis and non-cirrhotic portal hypertension in a 14-year-old girl"],"prefix":"10.1093","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9587-336X","authenticated-orcid":false,"given":"Cyriac Abby","family":"Philips","sequence":"first","affiliation":[{"name":"Rajagiri Hospital Clinical and Translational Hepatology & Monarch Liver Laboratory, The Liver Institute, Center of Excellence in GI Sciences, , Aluva, Kerala, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rizwan","family":"Ahamed","sequence":"additional","affiliation":[{"name":"Rajagiri Hospital Gastroenterology & Advanced GI Endoscopy, Center of Excellence in GI Sciences, , Aluva, Kerala, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinsha K","family":"Abduljaleel","sequence":"additional","affiliation":[{"name":"Rajagiri Hospital Gastroenterology & Advanced GI Endoscopy, Center of Excellence in GI Sciences, , Aluva, Kerala, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sasidharan","family":"Rajesh","sequence":"additional","affiliation":[{"name":"Rajagiri Hospital Interventional Hepatobiliary Radiology, The Liver Institute, Center of Excellence in GI Sciences, , Aluva, Kerala, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arif Hussain","family":"Theruvath","sequence":"additional","affiliation":[{"name":"Rajagiri Hospital Division of Complementary and Alternative Medicine (Homoeopathy), Department of Clinical Research, The Liver Institute, Center for Excellence in Gastrointestinal Sciences, , Aluva, Kerala, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Resmi","family":"Raveendran","sequence":"additional","affiliation":[{"name":"Rajagiri Hospital Division of Complementary and Alternative Medicine (Ayurveda), Department of Clinical Research, The Liver Institute, Center for Excellence in Gastrointestinal Sciences, , Aluva, Kerala, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Augustine","sequence":"additional","affiliation":[{"name":"Rajagiri Hospital Gastroenterology & Advanced GI Endoscopy, Center of Excellence in GI Sciences, , Aluva, Kerala, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,10,22]]},"reference":[{"key":"2022102409073061800_ref1","first-page":"147","article-title":"Alcoholic liver disease: pathogenesis and current management","volume":"38","author":"Osna","year":"2017","journal-title":"Alcohol Res"},{"key":"2022102409073061800_ref2","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1038\/s41395-018-0154-0","article-title":"Severe alcoholic hepatitis in a teetotaler","volume":"113","author":"Philips","year":"2018","journal-title":"Am J Gastroenterol"},{"key":"2022102409073061800_ref3","doi-asserted-by":"crossref","first-page":"e229627","DOI":"10.1136\/bcr-2019-229627","article-title":"Homeopathy-medicine induced severe alcoholic hepatitis","volume":"12","author":"Philips","year":"2019","journal-title":"BMJ Case 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