{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:14:48Z","timestamp":1753877688671,"version":"3.41.2"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2022,12,18]],"date-time":"2022-12-18T00:00:00Z","timestamp":1671321600000},"content-version":"vor","delay-in-days":17,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Subclinical hyperthyroidism (SH) is a condition in which blood levels of Thyroxine (T4) and Triiodothyronine (T3) are normal in the presence of low levels of thyroid-stimulating hormone (TSH). Patients with SH have either no symptoms or mild nonspecific symptoms. Hypokalemic periodic paralysis (HPP) is one of the rare presentations of overt hyperthyroidism; however, only a few cases are reported to date to occur with SH. This case report presents a case of a young Asian male who was admitted to the emergency department (ED) with paralysis of the lower extremities that progressed to the upper extremities and neck muscles in 2 days. Clinically, he was euthyroid; however, his thyroid profile revealed normal levels of T3 and T4 with undetectable TSH levels. This case report aims to add to the limited literature on SH that presents with HPP in the ED.<\/jats:p>","DOI":"10.1093\/omcr\/omac142","type":"journal-article","created":{"date-parts":[[2022,12,18]],"date-time":"2022-12-18T13:07:36Z","timestamp":1671368856000},"source":"Crossref","is-referenced-by-count":0,"title":["Subclinical hyperthyroidism presenting with hypokalemic periodic paralysis in the emergency department"],"prefix":"10.1093","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3969-0008","authenticated-orcid":false,"given":"Nirdosh","family":"Kumar","sequence":"first","affiliation":[{"name":"Aga Khan University Hospital Emergency Medicine, , Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sohaib","family":"Haider","sequence":"additional","affiliation":[{"name":"Aga Khan University Hospital Emergency Medicine, , Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anam","family":"Tariq","sequence":"additional","affiliation":[{"name":"Aga Khan University Hospital , Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Afzal","sequence":"additional","affiliation":[{"name":"Aga Khan University Hospital Emergency Medicine, , Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,12,16]]},"reference":[{"volume-title":"Hypokalemic Periodic Paralysis\u2014GeneReviews\u00ae\u2014NCBI Bookshelf","key":"2022121813071950700_ref1"},{"key":"2022121813071950700_ref2","doi-asserted-by":"crossref","first-page":"168","DOI":"10.4103\/ijem.IJEM_619_18","article-title":"Hypokalemic periodic paralysis and spectrum of thyroid disorders: analysis of 7 cases from Northern India","volume":"23","author":"Aggarwal","year":"2019","journal-title":"Indian J Endocrinol Metab"},{"key":"2022121813071950700_ref3","doi-asserted-by":"crossref","first-page":"bcr2014206872","DOI":"10.1136\/bcr-2014-206872","article-title":"Sudden flaccid paralysis","volume":"2015","author":"Tariq","year":"2015","journal-title":"BMJ Case Rep"},{"key":"2022121813071950700_ref4","doi-asserted-by":"crossref","first-page":"e1689","DOI":"10.1097\/MD.0000000000001689","article-title":"Hypokalemic paralysis complicated by concurrent hyperthyroidism and chronic alcoholism: a case report","volume":"94","author":"Tsai","year":"2015","journal-title":"Medicine"},{"key":"2022121813071950700_ref5","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2014-204198","article-title":"Thyrotoxic hypokalaemic periodic paralysis: a rare presentation of Graves\u2019 disease in a Hispanic patient","volume":"2014","author":"Matta","year":"2014","journal-title":"BMJ Case Rep"},{"key":"2022121813071950700_ref6","first-page":"bcr2014207945","article-title":"Muscle paralysis in thyrotoxicosis","author":"Siddiqui","year":"2015","journal-title":"Case Rep"},{"key":"2022121813071950700_ref7","article-title":"Hypokalaemic periodic paralysis secondary to subclinical hyperthyroidism: an uncommon cause of acute muscle paralysis","volume":"14","author":"Payus","year":"2021","journal-title":"BMJ Case Reports CP"},{"key":"2022121813071950700_ref8","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1681\/ASN.2012010046","article-title":"Mechanism of thyrotoxic periodic paralysis","volume":"23","author":"Lin","year":"2012","journal-title":"J Am Soc Nephrol"},{"volume-title":"Hyperkalemic Periodic Paralysis\u2014UpToDate","key":"2022121813071950700_ref9"}],"container-title":["Oxford Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2022\/12\/omac142\/47998177\/omac142.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2022\/12\/omac142\/47998177\/omac142.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,18]],"date-time":"2022-12-18T13:07:40Z","timestamp":1671368860000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/omcr\/article\/doi\/10.1093\/omcr\/omac142\/6916848"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,1]]},"references-count":9,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12,1]]}},"URL":"https:\/\/doi.org\/10.1093\/omcr\/omac142","relation":{},"ISSN":["2053-8855"],"issn-type":[{"type":"electronic","value":"2053-8855"}],"subject":[],"published-other":{"date-parts":[[2022,12]]},"published":{"date-parts":[[2022,12,1]]},"article-number":"omac142"}}