{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:49:26Z","timestamp":1791380966824,"version":"4.3.3"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T00:00:00Z","timestamp":1674172800000},"content-version":"vor","delay-in-days":19,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Rhabdomyosarcoma (RMS) is a highly invasive malignant soft tissue sarcoma that rarely affects adults. The head and neck region accounts for most adult RMSs. Here, we report a case of a 24-year-old Caucasian woman who was diagnosed with persistent hoarseness and a painless left-sided neck mass. Physical examination and image studies showed a massive tumor of the nasopharynx, extending from the left-sided skull base to supraglottic structures. Histopathologic evaluation revealed the diagnosis of a poorly differentiated RMS. Due to the primary tumor size and involvement of crucial structures, extensive surgical excision was not amenable. Thus, the patient was treated with radiotherapy and chemotherapy. Although very rare, nasopharyngeal RMSs should be considered in the differential diagnosis of neck masses in adult patients. This case report illustrates the difficulty in the diagnosis and treatment of rare head and neck malignancies and encourages its reporting.<\/jats:p>","DOI":"10.1093\/omcr\/omac148","type":"journal-article","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T12:10:56Z","timestamp":1674216656000},"source":"Crossref","is-referenced-by-count":1,"title":["Massive nasopharyngeal rhabdomyosarcoma in an adult patient: a rare case report"],"prefix":"10.1093","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2356-7494","authenticated-orcid":false,"given":"Christopher","family":"Seifen","sequence":"first","affiliation":[{"name":"University Medical Center Mainz Department of Otolaryngology, Head and Neck Surgery, , Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Matthias","sequence":"additional","affiliation":[{"name":"University Medical Center Mainz Department of Otolaryngology, Head and Neck Surgery, , Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karoline","family":"O'Brien","sequence":"additional","affiliation":[{"name":"University Medical Center Mainz Department of Otolaryngology, Head and Neck Surgery, , Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,1,18]]},"reference":[{"key":"2023012012104723500_ref1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/BF01936232","article-title":"Anatomische Untersuchung einer hypertrophischen Zunge nebst Bemerkungen \u00fcber die Neubildung quergestreifter Muskelfasern","volume":"7","author":"Weber","year":"1854","journal-title":"Virchows Arch"},{"key":"2023012012104723500_ref2","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1002\/cncr.11550","article-title":"Rhabdomyosarcoma in adults. A retrospective analysis of 171 patients treated at a single institution","volume":"98","author":"Ferrari","year":"2003","journal-title":"Cancer"},{"key":"2023012012104723500_ref3","doi-asserted-by":"crossref","first-page":"3391","DOI":"10.1200\/JCO.2008.19.7483","article-title":"Comparing adult and pediatric rhabdomyosarcoma in the surveillance, epidemiology and end results program, 1973 to 2005: an analysis of 2,600 patients","volume":"27","author":"Sultan","year":"2009","journal-title":"J Clin Oncol"},{"key":"2023012012104723500_ref4","first-page":"115","article-title":"Rhabdomyosarcoma in adolescent and young adult patients: current perspectives","volume":"5","author":"Egas-Bejar","year":"2014","journal-title":"Adolesc Health Med Ther"},{"key":"2023012012104723500_ref5","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1067\/moe.2002.123860","article-title":"Rhabdomyosarcoma of the oral and maxillofacial region in Jordanians: a retrospective analysis","volume":"93","author":"Al-Khateeb","year":"2002","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"2023012012104723500_ref6","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1200\/JCO.2007.14.7207","article-title":"Prognostic factors in metastatic rhabdomyosarcomas: results of a pooled analysis from United States and European cooperative groups","volume":"26","author":"Oberlin","year":"2008","journal-title":"J Clin Oncol"},{"key":"2023012012104723500_ref7","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1177\/014556130508401214","article-title":"Rhabdomyosarcoma of the middle ear and mastoid: a case report and review of the literature","volume":"84","author":"Abbas","year":"2005","journal-title":"Ear Nose Throat J"}],"container-title":["Oxford Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2023\/1\/omac148\/48756635\/omac148.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2023\/1\/omac148\/48756635\/omac148.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T12:11:01Z","timestamp":1674216661000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/omcr\/article\/doi\/10.1093\/omcr\/omac148\/6991145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,1]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/omcr\/omac148","relation":{},"ISSN":["2053-8855"],"issn-type":[{"value":"2053-8855","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,1]]},"published":{"date-parts":[[2023,1,1]]},"article-number":"omac148"}}