{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T12:34:20Z","timestamp":1764333260579,"version":"3.41.2"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T00:00:00Z","timestamp":1674172800000},"content-version":"vor","delay-in-days":19,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Seronegative rheumatoid arthritis (RA) is less likely to have extra-articular manifestations than seropositive RA. An 80-year-old man with polyarthritis was diagnosed with seronegative RA in which rheumatoid factors and anti-cyclic citrullinated peptides were not detected. He had multiple pulmonary nodules that diminished in size following treatment for RA, leading to the diagnosis of pulmonary rheumatoid nodules. During his treatment course, he developed scleritis, which could have resulted in blindness. As oral steroids did not improve his condition, topical steroid injections were administered, and his symptoms gradually improved. Here, we present a case of seronegative RA with an unusual combination of extra-articular manifestations: rheumatoid pulmonary nodules and scleritis.<\/jats:p>","DOI":"10.1093\/omcr\/omac155","type":"journal-article","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T12:10:30Z","timestamp":1674216630000},"source":"Crossref","is-referenced-by-count":3,"title":["A rare case of scleritis and multiple rheumatoid pulmonary nodules associated with seronegative rheumatoid arthritis"],"prefix":"10.1093","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1558-1912","authenticated-orcid":false,"given":"Fumikazu","family":"Sato","sequence":"first","affiliation":[{"name":"Koseiren Takaoka Hospital Department of Nephrology and Rheumatology, , Takaoka, Toyama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Yamano","sequence":"additional","affiliation":[{"name":"Koseiren Takaoka Hospital Department of Nephrology and Rheumatology, , Takaoka, Toyama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshimi","family":"Manbo","sequence":"additional","affiliation":[{"name":"Koseiren Takaoka Hospital Department of Ophthalmology, , Takaoka, Toyama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimikazu","family":"Sakaguchi","sequence":"additional","affiliation":[{"name":"Koseiren Takaoka Hospital Department of Ophthalmology, , Takaoka, Toyama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaori","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Koseiren Takaoka Hospital Department of Nephrology and Rheumatology, , Takaoka, Toyama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taito","family":"Miyake","sequence":"additional","affiliation":[{"name":"Koseiren Takaoka Hospital Department of Nephrology and Rheumatology, , Takaoka, Toyama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,1,18]]},"reference":[{"key":"2023012012101907000_ref1","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1136\/annrheumdis-2019-216655","article-title":"EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2019 update","volume":"79","author":"Smolen","year":"2020","journal-title":"Ann Rheum Dis"},{"key":"2023012012101907000_ref2","doi-asserted-by":"crossref","first-page":"595","DOI":"10.3899\/jrheum.170437","article-title":"Clinical correlates, outcomes, and predictors of inflammatory ocular disease associated with rheumatoid arthritis in the biologic era","volume":"45","author":"Caimmi","year":"2018","journal-title":"J Rheumatol"},{"key":"2023012012101907000_ref3","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1007\/s00330-018-5755-x","article-title":"Rheumatoid pulmonary nodules: clinical and imaging features compared with malignancy","volume":"29","author":"Koslow","year":"2019","journal-title":"Eur Radiol"},{"key":"2023012012101907000_ref4","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.3390\/jcm10102118","article-title":"Clinical medicine rheumatoid arthritis associated episcleritis and scleritis: an update on treatment perspectives","volume":"10","author":"Promelle","year":"2021","journal-title":"J Clin Med"},{"key":"2023012012101907000_ref5","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1097\/APO.0000000000000341","article-title":"Current approach for the diagnosis and management of noninfective scleritis","volume":"10","author":"Dutta Majumder","year":"2020","journal-title":"Asia Pac J Ophthalmol (Phila)"},{"key":"2023012012101907000_ref6","article-title":"Management of noninfectious scleritis","volume":"14","author":"Abdel-Aty","year":"2022","journal-title":"Ther Adv Ophthalmol"},{"key":"2023012012101907000_ref7","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.det.2015.03.004","article-title":"Rheumatoid nodules","volume":"33","author":"Tilstra","year":"2015","journal-title":"Dermatol Clin"}],"container-title":["Oxford Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2023\/1\/omac155\/48756602\/omac155.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2023\/1\/omac155\/48756602\/omac155.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T12:10:36Z","timestamp":1674216636000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/omcr\/article\/doi\/10.1093\/omcr\/omac155\/6991139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,1]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/omcr\/omac155","relation":{},"ISSN":["2053-8855"],"issn-type":[{"type":"electronic","value":"2053-8855"}],"subject":[],"published-other":{"date-parts":[[2023,1]]},"published":{"date-parts":[[2023,1,1]]},"article-number":"omac155"}}