{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:14:52Z","timestamp":1753877692165,"version":"3.41.2"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T00:00:00Z","timestamp":1677456000000},"content-version":"vor","delay-in-days":26,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Scurvy is a rare nutritional deficiency, particularly in developed nations. Sporadic cases are still reported, particularly among alcoholics and malnourished. Herein we present an unusual case of a previously healthy 15-year-old Caucasian girl, who was recently hospitalized for low velocity spine fractures, back pain and stiffness over several months and rash for 2 years. She was later diagnosed with scurvy and osteoporosis. Dietary modifications were instituted together with supplementary vitamin C, supportive treatment with regular dietician review and physiotherapy. Gradual clinical recovery was seen over the course of therapy. Our case highlights the importance of recognizing scurvy even among low-risk populations to ensure prompt and effective clinical management.<\/jats:p>","DOI":"10.1093\/omcr\/omad015","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T13:26:25Z","timestamp":1677504385000},"source":"Crossref","is-referenced-by-count":0,"title":["Fatigue, bleeding tendency and osteoporosis in an adolescent: a diagnostic conundrum"],"prefix":"10.1093","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8466-3482","authenticated-orcid":false,"given":"Salwana","family":"Ku Md. Saad","sequence":"first","affiliation":[{"name":"Sligo University Hospital Department of Paediatrics, , Sligo, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3571-3399","authenticated-orcid":false,"given":"Karniza","family":"Khalid","sequence":"additional","affiliation":[{"name":"Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia Endocrine Unit, Specialised Diagnostic Centre, , Kuala Lumpur, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sinead","family":"Glackin","sequence":"additional","affiliation":[{"name":"Sligo University Hospital Department of Paediatrics, , Sligo, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,2,27]]},"reference":[{"key":"2023022713261355700_","doi-asserted-by":"crossref","first-page":"615","DOI":"10.3390\/nu13020615","article-title":"Vitamin C\u2014sources, physiological role, kinetics, deficiency, use, toxicity, and determination","volume":"13","author":"Dosed\u011bl","year":"2021","journal-title":"Nutrients"},{"key":"2023022713261355700_","doi-asserted-by":"crossref","first-page":"397","DOI":"10.3389\/fphys.2015.00397","article-title":"Vitamin C in health and disease: its role in the metabolism of cells and redox state in the brain","volume":"6","author":"Figueroa-M\u00e9ndez","year":"2015","journal-title":"Front Physiol"},{"key":"2023022713261355700_","doi-asserted-by":"crossref","DOI":"10.1016\/B978-0-08-101020-4.00002-1","volume-title":"The bioarchaeology of metabolic bone disease","author":"Brickley","year":"2020"},{"key":"2023022713261355700_","first-page":"227","volume-title":"Baylor University Medical Center Proceedings","author":"Baradhi","year":"2018"},{"key":"2023022713261355700_","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jbspin.2004.01.007","article-title":"Musculoskeletal manifestations of scurvy","volume":"72","author":"Fain","year":"2005","journal-title":"Jt Bone Spine"},{"key":"2023022713261355700_","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.3390\/nu12082394","article-title":"Role of vitamin C in osteoporosis development and treatment\u2014a literature review","volume":"12","author":"Brzezi\u0144ska","year":"2020","journal-title":"Nutrients"},{"key":"2023022713261355700_","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0140-6736(18)31491-0","article-title":"A classic case of scurvy","volume":"392","author":"Lipner","year":"2018","journal-title":"Lancet"},{"key":"2023022713261355700_","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s12603-010-0032-y","article-title":"Scurvy in hospitalized elderly patients","volume":"14","author":"Raynaud-Simon","year":"2010","journal-title":"J Nutr Health Aging"},{"key":"2023022713261355700_","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12887-019-1605-5","article-title":"Scurvy presenting with limp and weakness: a case report","volume":"19","author":"Lund","year":"2019","journal-title":"BMC Pediatr"},{"key":"2023022713261355700_","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1182\/hematology.2019000066","article-title":"Management of rare acquired bleeding disorders","volume":"2019","author":"Menegatti","year":"2019","journal-title":"Hematology"}],"container-title":["Oxford Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2023\/2\/omad015\/49342750\/omad015.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2023\/2\/omad015\/49342750\/omad015.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T17:36:51Z","timestamp":1679852211000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/omcr\/article\/doi\/10.1093\/omcr\/omad015\/7058738"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,1]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2,1]]}},"URL":"https:\/\/doi.org\/10.1093\/omcr\/omad015","relation":{},"ISSN":["2053-8855"],"issn-type":[{"type":"electronic","value":"2053-8855"}],"subject":[],"published-other":{"date-parts":[[2023,2]]},"published":{"date-parts":[[2023,2,1]]},"article-number":"omad015"}}