{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:13:59Z","timestamp":1753877639191,"version":"3.41.2"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T00:00:00Z","timestamp":1685404800000},"content-version":"vor","delay-in-days":29,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Amyotrophic lateral sclerosis (ALS) is a progressive, degenerative neuromuscular condition. The procedure and difficulties involved in the clinical diagnosis of ALS have been the subject of numerous investigations. The understanding of the genetics and the epigenetics of the disease is still at infancy with several missing links. We present a case report of a 73-year-old woman suffering from bulbar onset ALS with a 4-month history of progressive dysphagia and dyspnea. She displayed tongue fasciculations and muscle atrophy. The bilateral palmomental reflexes, snout reflex, Hoffman, Babinski, diminished gag reflex, bilateral clonus and wild mood swings confirmed the neurodegenerative condition of the patient. The diagnosis of ALS can be challenging; therefore, the data presented may be useful to investigate its characteristics of the onset and to improve the understanding of the aspects of differentiation from other neurodegenerative disorders.<\/jats:p>","DOI":"10.1093\/omcr\/omad045","type":"journal-article","created":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T11:48:44Z","timestamp":1685447324000},"source":"Crossref","is-referenced-by-count":0,"title":["Bulbar onset amyotrophic lateral sclerosis with more evident symptoms in the left hemibody: a case report"],"prefix":"10.1093","volume":"2023","author":[{"given":"Manisha","family":"Chavan","sequence":"first","affiliation":[{"name":"Kakatiya Medical College Department of Medicine, , RangamPeta, Warangal, Telangana 506007, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay","family":"Singh","sequence":"additional","affiliation":[{"name":"Sri Ram MurtiSmarak Institute of Medical Sciences Department of Medicine, , Bareilly, Uttar Pradesh 243202, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pinank K","family":"Bathvar","sequence":"additional","affiliation":[{"name":"SMT. NHL Municipal Medical College Department of Medicine, , Ahmedabad, Gujarat 380006, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarang T","family":"Mehta","sequence":"additional","affiliation":[{"name":"SMT. NHL Municipal Medical College Department of Medicine, , Ahmedabad, Gujarat 380006, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdul K","family":"Qadree","sequence":"additional","affiliation":[{"name":"Caribbean Medical University Department of Medicine, , Willemstad 4797, Cura\u00e7ao"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandesh","family":"Dhakal","sequence":"additional","affiliation":[{"name":"College of Medical Sciences Department of Medicine, , Bharatpur 44207, Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,5,30]]},"reference":[{"key":"2023072121241665900_ref1","doi-asserted-by":"crossref","first-page":"310","DOI":"10.3109\/17482960802566824","article-title":"Prognostic factors in ALS: a critical review","volume":"10","author":"Chi\u00f2","year":"2009","journal-title":"Amyotroph Lateral Scler"},{"key":"2023072121241665900_ref2","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1136\/jnnp.2010.235952","article-title":"Phenotypic heterogeneity of amyotrophic lateral sclerosis: a population based study","volume":"82","author":"Chi\u00f2","year":"2011","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2023072121241665900_ref3","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/j.1600-0404.2004.00362.x","article-title":"Clinical and epidemiological features of motor neuron disease in South-Western Greece","volume":"111","author":"Argyriou","year":"2005","journal-title":"Acta Neurol Scand"},{"key":"2023072121241665900_ref4","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1136\/jnnp.2004.048652","article-title":"Molecular and cellular pathways of neurodegeneration in motor neurone disease","volume":"76","author":"Shaw","year":"2005","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2023072121241665900_ref5","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.ncl.2015.07.003","article-title":"Amyotrophic lateral sclerosis regional variants (brachial amyotrophic Diplegia, leg amyotrophic Diplegia, and isolated bulbar amyotrophic lateral sclerosis)","volume":"33","author":"Jawdat","year":"2015","journal-title":"Neurol Clin"},{"key":"2023072121241665900_ref6","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3109\/17482968.2011.551940","article-title":"Isolated bulbar phenotype of amyotrophic lateral sclerosis","volume":"12","author":"Burrell","year":"2011","journal-title":"Amyotroph Lateral Scler"},{"key":"2023072121241665900_ref7","doi-asserted-by":"crossref","first-page":"364","DOI":"10.3109\/17482960903513159","article-title":"The clinical course of progressive bulbar palsy","volume":"11","author":"Karam","year":"2010","journal-title":"Amyotroph Lateral Scler"}],"container-title":["Oxford Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2023\/5\/omad045\/50921508\/omad045.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2023\/5\/omad045\/50921508\/omad045.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T21:24:26Z","timestamp":1689974666000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/omcr\/article\/doi\/10.1093\/omcr\/omad045\/7186216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,1]]},"references-count":7,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5,1]]}},"URL":"https:\/\/doi.org\/10.1093\/omcr\/omad045","relation":{},"ISSN":["2053-8855"],"issn-type":[{"type":"electronic","value":"2053-8855"}],"subject":[],"published-other":{"date-parts":[[2023,5]]},"published":{"date-parts":[[2023,5,1]]},"article-number":"omad045"}}