{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T05:00:44Z","timestamp":1764306044559,"version":"3.41.2"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T00:00:00Z","timestamp":1685404800000},"content-version":"vor","delay-in-days":29,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Thyroid storm is a rare, life-threatening condition that is usually precipitated by Graves\u2019 disease in children and adolescents. COVID-19 (SARS-CoV-2) can cause multisystem inflammatory syndrome in children (MIS C), which shares some features of Graves\u2019 disease. We present a case of acute thyroid storm following SARS-CoV-2 infection in a 16-year-old female with poorly controlled Graves\u2019 disease. She initially presented to the emergency department for fever and palpitations. Initial laboratory results suggested thyroid storm, for which she was started on propranolol. She remained tachycardic with new gallop rhythm on exam. An echocardiogram demonstrated a depressed left ventricular ejection fraction and mild pulmonary hypertension. Her SARS-CoV-2 antibodies were positive. She was started on intravenous immunoglobulin for suspected MIS-C. She responded to combined treatment of thyroid storm and MIS-C. She was discharged home on propranolol, methimazole, cholestyramine and aspirin.<\/jats:p>","DOI":"10.1093\/omcr\/omad050","type":"journal-article","created":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T11:51:25Z","timestamp":1685447485000},"source":"Crossref","is-referenced-by-count":2,"title":["Acute febrile illness in a teenage female with history of Graves\u2019 disease"],"prefix":"10.1093","volume":"2023","author":[{"given":"Mark W","family":"Rushing","sequence":"first","affiliation":[{"name":"The University of Tennessee Health Science Center College of Medicine Department of Pediatrics, Division of Pediatric Cardiology, , Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A","family":"Rebolledo","sequence":"additional","affiliation":[{"name":"The University of Tennessee Health Science Center College of Medicine Department of Pediatrics, Division of Pediatric Cardiology, , Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Lahoti","sequence":"additional","affiliation":[{"name":"Nationwide Children\u2019s Hospital Department of Pediatrics, Division of Pediatric Endocrinology, , Columbus, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramin","family":"Alemzadeh","sequence":"additional","affiliation":[{"name":"The University of Tennessee Health Science Center College of Medicine Department of Pediatrics, Division of Pediatric Endocrinology, , Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,5,30]]},"reference":[{"key":"2023053108013010200_ref1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0889-8529(18)30165-8","article-title":"Life-threatening thyrotoxicosis. Thyroid storm","volume":"22","author":"Burch","year":"1993","journal-title":"Endocrinol Metab Clin N Am"},{"key":"2023053108013010200_ref2","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1002\/art.41454","article-title":"American College of Rheumatology Clinical Guidance for multisystem inflammatory syndrome in children associated with SARS-CoV-2 and hyperinflammation in Pediatric COVID-19: version 1","volume":"72","author":"Henderson","year":"2020","journal-title":"Arthritis Rheumatol"},{"key":"2023053108013010200_ref3","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1089\/thy.2017.0243","article-title":"Thyroid storm: a Japanese perspective","volume":"28","author":"Akamizu","year":"2018","journal-title":"Thyroid"},{"issue":"9","key":"2023053108013010200_ref4","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1089\/thy.2011.0334","article-title":"Diagnostic criteria, clinical features, and incidence of thyroid storm based on nationwide surveys [published correction appears in thyroid]","volume":"22","author":"Akamizu","year":"2012","journal-title":"Thyroid"},{"key":"2023053108013010200_ref5","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.ecl.2006.09.008","article-title":"Thyrotoxicosis and thyroid storm","volume":"35","author":"Nayak","year":"2006","journal-title":"Endocrinol Metab Clin N Am"},{"key":"2023053108013010200_ref6","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1530\/EJE-20-0335","article-title":"Thyrotoxicosis in patients with COVID-19: the THYRCOV study","volume":"183","author":"Lania","year":"2020","journal-title":"Eur J Endocrinol"},{"key":"2023053108013010200_ref7","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1530\/EJE-20-0335","article-title":"Thyrotoxicosis in patients with COVID-19: the THYRCOV study","volume":"183","author":"Lania","year":"2020","journal-title":"Eur J Endocrinol"},{"volume-title":"Presented at Society for Endocrinology BES 2017","year":"2017","author":"Arnold","key":"2023053108013010200_ref8"},{"key":"2023053108013010200_ref9","article-title":"Impact of COVID-19 on the thyroid gland: an update","volume":"22","author":"Scappaticcio","journal-title":"Reviews in Endocrine & Metabolic Disorders"},{"key":"2023053108013010200_ref10","doi-asserted-by":"crossref","first-page":"413","DOI":"10.4183\/aeb.2021.413","article-title":"Coronavirus as a trigger of Graves' disease","volume":"17","author":"Urbanovych","year":"2021","journal-title":"Acta Endocrinol (Buchar)"}],"container-title":["Oxford Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2023\/5\/omad050\/50492881\/omad050.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2023\/5\/omad050\/50492881\/omad050.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T08:03:59Z","timestamp":1685520239000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/omcr\/article\/doi\/10.1093\/omcr\/omad050\/7186214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,1]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5,1]]}},"URL":"https:\/\/doi.org\/10.1093\/omcr\/omad050","relation":{},"ISSN":["2053-8855"],"issn-type":[{"type":"electronic","value":"2053-8855"}],"subject":[],"published-other":{"date-parts":[[2023,5]]},"published":{"date-parts":[[2023,5,1]]},"article-number":"omad050"}}