{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:13:56Z","timestamp":1753877636919,"version":"3.41.2"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T00:00:00Z","timestamp":1698105600000},"content-version":"vor","delay-in-days":23,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Familial Mediterranean fever (FMF) is an inherited autoinflammatory disease that affects the skin, joints, serous membranes and other various organs. Presentation of FMF can be solely but it can coexist with other conditions. It has been shown that it can be accompanied by various different disorders. Scleroderma is an autoimmune dermatologic condition that can present with systemic manifestations. No previous cases about the coexistence of FMF and scleroderma were previously documented, therefore we report the first case in Syria of a 10-year-old female that presented with clinically clear signs of both conditions (periodic fever and serous chest pain in addition to skin hyperpigmentation). The patient\u2019s symptoms required full genetic testing along with the proper antibody detection and The diagnosis of FMF and scleroderma was confirmed by genetic testing and treatment was started.<\/jats:p>","DOI":"10.1093\/omcr\/omad111","type":"journal-article","created":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T20:49:50Z","timestamp":1698180590000},"source":"Crossref","is-referenced-by-count":0,"title":["Familial Mediterranean fever and scleroderma: a rare case report from Syria"],"prefix":"10.1093","volume":"2023","author":[{"given":"Lujain","family":"Nahas","sequence":"first","affiliation":[{"name":"Damascus University Faculty of Medicine, , Damascus, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rawan","family":"Al Khudari","sequence":"additional","affiliation":[{"name":"Damascus University Department of Pediatrics, Children\u2019s University Hospital, Faculty of Medicine, , Damascus, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basheer","family":"Khalil","sequence":"additional","affiliation":[{"name":"Damascus University Division of Rheumatology, Department of Pediatrics, Children\u2019s University Hospital, Faculty of Medicine, , Damascus, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,10,23]]},"reference":[{"key":"2023102420473188300_ref1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.14712\/18059694.2014.47","article-title":"Familial Mediterranean fever","volume":"57","author":"Kucuk","year":"2014","journal-title":"Acta Med (Hradec Kralove)"},{"key":"2023102420473188300_ref2","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.pcl.2018.04.002","article-title":"Scleroderma in children and adolescents: localized scleroderma and systemic sclerosis","volume":"65","author":"Li","year":"2018","journal-title":"Pediatr Clin N Am"},{"key":"2023102420473188300_ref3","doi-asserted-by":"crossref","first-page":"150","DOI":"10.5114\/reum.2020.96688","article-title":"Familial Mediterranean fever: what associations to screen for","volume":"58","author":"Bouomrani","year":"2020","journal-title":"Reumatologia"},{"key":"2023102420473188300_ref4","first-page":"117","article-title":"Familial Mediterranean fever and multiple sclerosis\u2014a case report","volume":"34","author":"Ugurlu","year":"2009","journal-title":"Acta Reumatol Port"},{"key":"2023102420473188300_ref5","first-page":"144","article-title":"Autoantibodies are not associated with familial mediterranean fever","volume":"37","author":"Guler","year":"2012","journal-title":"Acta Reumatol Port"},{"key":"2023102420473188300_ref6","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1002\/iid3.475","article-title":"Upcoming treatments for morphea","volume":"9","author":"Wenzel","year":"2021","journal-title":"Immun Inflamm Dis"},{"volume-title":"Morphea","year":"2023","author":"Penmetsa","key":"2023102420473188300_ref7"},{"key":"2023102420473188300_ref8","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1097\/BOR.0000000000000904","article-title":"Scleroderma autoantibodies in guiding monitoring and treatment decisions","volume":"34","author":"Shah","year":"2022","journal-title":"Curr Opin Rheumatol"}],"container-title":["Oxford Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2023\/10\/omad111\/52406149\/omad111.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2023\/10\/omad111\/52406149\/omad111.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T20:49:54Z","timestamp":1698180594000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/omcr\/article\/doi\/10.1093\/omcr\/omad111\/7327048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,1]]},"references-count":8,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/omcr\/omad111","relation":{},"ISSN":["2053-8855"],"issn-type":[{"type":"electronic","value":"2053-8855"}],"subject":[],"published-other":{"date-parts":[[2023,10]]},"published":{"date-parts":[[2023,10,1]]},"article-number":"omad111"}}