{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:45:25Z","timestamp":1763037925474,"version":"3.41.2"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T00:00:00Z","timestamp":1701216000000},"content-version":"vor","delay-in-days":28,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Secondary central nervous system (CNS) relapse by aggressive non-Hodgkin\u2019s lymphoma is a well-known complication portending a very poor prognosis. Conversely, patients with indolent lymphoma-like follicular lymphoma (FL) rarely present with CNS involvement and, thus, limited information is currently available. We herein describe a patient with FL who developed CNS involvement during chemotherapy. Treatment including high-dose methotrexate and radiation therapy was ineffective and the patient died 5\u00a0months after CNS relapse. In a literature review, there were 8 case reports of the secondary CNS relapse of FL. The findings obtained suggest that bone marrow infiltration is a risk factor for CNS relapse. Moreover, 5 out of 9 patients died within 2.5\u00a0years, indicating a poorer prognosis than that of FL. Therefore, it is important to promptly perform detailed examinations as soon as neurological findings appear.<\/jats:p>","DOI":"10.1093\/omcr\/omad118","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T13:51:20Z","timestamp":1701265880000},"source":"Crossref","is-referenced-by-count":2,"title":["Follicular lymphoma with secondary central nervous system relapse: a case report and literature review"],"prefix":"10.1093","volume":"2023","author":[{"given":"Yuri","family":"Tsuboi","sequence":"first","affiliation":[{"name":"Hitachi General Hospital Department of Hematology and Oncology, , Hitachi, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Misayo","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Hitachi General Hospital Department of Hematology and Oncology, , Hitachi, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Hitachi General Hospital Department of Hematology and Oncology, , Hitachi, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Suyama","sequence":"additional","affiliation":[{"name":"Hitachi General Hospital Department of Hematology and Oncology, , Hitachi, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Seki","sequence":"additional","affiliation":[{"name":"Hitachi General Hospital Department of Hematology and Oncology, , Hitachi, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Shinagawa","sequence":"additional","affiliation":[{"name":"Hitachi General Hospital Department of Hematology and Oncology, , Hitachi, Ibaraki, 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