{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T14:05:40Z","timestamp":1778508340984,"version":"3.51.4"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T00:00:00Z","timestamp":1701216000000},"content-version":"vor","delay-in-days":28,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Encephalitis occasionally occurs due to the central nervous system (CNS) infection by Varicella-zoster virus (VZV). The coincidence of herpes Encephalitis-brain infection and brucellosis occurs rarely. In this case, a 56-year-old woman was described with low consciousness, seizures, fever, and mood disorders. The brain CT revealed no pathological lesions, but MR showed non-specific plaques in the periventricular white matter. VZV was detected in molecular tests for the panel of viral Encephalitis in cerebrospinal fluid (CSF). The blood culture and the Wright test revealed the presence of Brucella spp. The antiviral treatment of choice was Acyclovir, Levetiracetam to control seizures, and Ampicillin\/Sulbactam as prophylaxis antibiotics. Coinfections common poor prognoses makes it crucial to administer antiviral medications immediately. Many clinical challenges require a multidisciplinary team, including involvement of the CNS, resistance to viral strains, reactivation of diseases, and drug toxicity. The early detection of Encephalitis and treatment can promptly prevent exacerbation and complications.<\/jats:p>","DOI":"10.1093\/omcr\/omad121","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T13:51:31Z","timestamp":1701265891000},"source":"Crossref","is-referenced-by-count":5,"title":["VZV Encephalitis with Brucella coinfection\u2014case report"],"prefix":"10.1093","volume":"2023","author":[{"given":"Fakhri","family":"Allahyari","sequence":"first","affiliation":[{"name":"Baqyiatallah University of Medical Sciences Neuroscience Research Center, , Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raheleh","family":"Halabian","sequence":"additional","affiliation":[{"name":"Baqiyatallah University of Medical Sciences Applied Microbiology Research Center, Systems Biology and Poisonings Institute, , Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javad Hosseini","family":"Nejad","sequence":"additional","affiliation":[{"name":"Baqyiatallah University of Medical Sciences Neuroscience Research Center, , Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,11,28]]},"reference":[{"key":"2023112913510911000_ref1","doi-asserted-by":"crossref","first-page":"588","DOI":"10.3390\/v14030588","article-title":"Effect of routine varicella immunization on the epidemiology and immunogenicity of varicella and shingles","volume":"14","author":"Otani","year":"2022","journal-title":"Viruses"},{"key":"2023112913510911000_ref2","doi-asserted-by":"crossref","first-page":"380","DOI":"10.5811\/cpcem.2019.8.43010","article-title":"Varicella zoster virus encephalitis","volume":"3","author":"Lizzi","year":"2019","journal-title":"Clin Pract Cases Emerg 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Neurocritical Care for acute neurological conditions","volume":"23","author":"Hrishi","year":"2019","journal-title":"Indian J Crit Care Med"},{"key":"2023112913510911000_ref7","doi-asserted-by":"crossref","DOI":"10.1128\/CMR.00073-19","article-title":"Laboratory diagnosis of human brucellosis","volume":"33","author":"Yagupsky","year":"2019","journal-title":"Clin Microbiol Rev"},{"key":"2023112913510911000_ref8","first-page":"1","article-title":"Brucellosis: treatment and prevention","author":"Bosilkovski","year":"2019"},{"key":"2023112913510911000_ref9","doi-asserted-by":"crossref","first-page":"1137932","DOI":"10.3389\/fmicb.2023.1137932","article-title":"Molecular characterization and antimicrobial susceptibility of human Brucella in Northeast China","volume":"14","author":"Ma","year":"2023","journal-title":"Front Microbiol"},{"key":"2023112913510911000_ref10","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1080\/13685538.2022.2138851","article-title":"Brucellosis in older person: a case report from Qatar","volume":"25","author":"Al Hamad","year":"2022","journal-title":"Aging Male"}],"container-title":["Oxford Medical Case 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