{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:30:45Z","timestamp":1777725045259,"version":"3.51.4"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T00:00:00Z","timestamp":1701216000000},"content-version":"vor","delay-in-days":28,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Introduction: Granulomatosis with polyangiitis (GPA) vasculitis typically involves upper and lower airways and kidneys. Gastrointestinal involvement is rare, clinically reported as esophageal involvement, gastrointestinal hemorrhage, intestinal perforation, colitis, and pancreatitis. Case presentation: We present a 36 old man, with intestinal perforation, laterally diagnosed as granulomatosis with polyangiitis. Discussion: Only a few cases of intestinal perforation have been reported in the medical literature. GI symptoms may be present after the disease diagnosis in years. Intestinal perforation usually required surgery. The frequent kidney involvement of GPA is rapidly progressive glomerulonephritis, presented as acute kidney injury, usually accompanied by GI symptoms. Cyclophosphamide plus corticosteroids remain the effective therapy. The patient with GPA had a normal life expectancy due to the advances in treatment. Renal involvement and GI manifestations are considered bad prognosis predictors. Conclusion: This case report illustrates the need to consider intestinal perforation in patients with granulomatosis with polyangiitis, early surgical intervention and appropriate immunosuppressive therapy can be lifesaving.<\/jats:p>","DOI":"10.1093\/omcr\/omad127","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T13:52:30Z","timestamp":1701265950000},"source":"Crossref","is-referenced-by-count":1,"title":["Intestinal perforation as a first presentation of granulomatosis with polyangiitis: unusual case report"],"prefix":"10.1093","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7161-979X","authenticated-orcid":false,"given":"Naram","family":"Khalayli","sequence":"first","affiliation":[{"name":"University of Damascus Department of Medicine, , Damascus, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6506-627X","authenticated-orcid":false,"given":"Maria","family":"Aldeeb","sequence":"additional","affiliation":[{"name":"University of Damascus Department of Medicine, , Damascus, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dani","family":"Abouharb","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 Department of Medicine, , Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lana","family":"Abouharb","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 Department of Medicine, , Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maysoun","family":"Kudsi","sequence":"additional","affiliation":[{"name":"University of Damascus Department of Medicine, , Damascus, 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