{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:14:01Z","timestamp":1753877641104,"version":"3.41.2"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:00:00Z","timestamp":1706486400000},"content-version":"vor","delay-in-days":28,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Neurobrucellosis is a serious focal brucella infection. Ventriculitis is a special form of central nervous infection where pyogenic infection of the ependymal linings hinders antibiotics\u2019 accessibility to the cerebrospinal fluids and leads to protracted infection. We present a case of a 37-year-old Shepherd who had low-grade fever for 5 months followed by a brief history of vomiting, abdominal pain, and gait imbalance. Investigations showed neutrophilic leukocytosis, high titers of serum anti-brucella antibodies, and lymphocytic pleocytosis. Mycobacterial tuberculosis workup was negative. Magnetic resonance imaging of the brain revealed cervical and spinal meningeal enhancement in addition to mild hydrocephalus. The patient was presumptively diagnosed with neurobrucellosis. He received treatment with ceftriaxone-based combination antibiotics therapy for 6 months with complete resolution of his symptoms. Central nervous infection by brucella is a challenging diagnosis. The possibility of primary ventriculitis due to Brucella infection mandates early recognition and prolonged antimicrobial therapy to achieve full recovery.<\/jats:p>","DOI":"10.1093\/omcr\/omad149","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T08:02:52Z","timestamp":1706515372000},"source":"Crossref","is-referenced-by-count":5,"title":["Neurobrucellosis complicated by primary pyogenic ventriculitis: a case report"],"prefix":"10.1093","volume":"2024","author":[{"given":"Mohammed","family":"Alhatou","sequence":"first","affiliation":[{"name":"Al-Khor Hospital, Hamad Medical Corporation Department of Neurology, , Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8323-1303","authenticated-orcid":false,"given":"Anwar I","family":"Joudeh","sequence":"additional","affiliation":[{"name":"Al-Khor Hospital, Hamad Medical Corporation Department of Internal Medicine, , Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abraham","family":"Alhatou","sequence":"additional","affiliation":[{"name":"Lincoln Memorial University DeBusk College of Osteopathic Medicine, , Tennessee, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Ghamoodi","sequence":"additional","affiliation":[{"name":"Al-Khor Hospital, Hamad Medical Corporation Department of Neurology, , Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,1,27]]},"reference":[{"key":"2024012908024143600_ref1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3389\/fvets.2022.976215","article-title":"Prevalence, diagnosis, and manifestations of brucellosis: a systematic review and meta-analysis","volume":"9","author":"Khoshnood","year":"2022","journal-title":"Front Vet 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mimicker","volume":"55","author":"Soares","year":"2022","journal-title":"Rev Soc Bras Med Trop."},{"key":"2024012908024143600_ref7","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3390\/tropicalmed3020065","article-title":"An overview of brucellosis in cattle and humans, and its serological and molecular diagnosis in control strategies","volume":"3","author":"Khan","year":"2018","journal-title":"Trop Med Infect Dis."},{"key":"2024012908024143600_ref8","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.neuroscience.2019.05.018","article-title":"Immune mediators of pathology in neurobrucellosis: from blood to central nervous system","volume":"410","author":"Rodr\u00edguez","year":"2019","journal-title":"Neuroscience."},{"key":"2024012908024143600_ref9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/00207454.2022.2100776","article-title":"Manifestations, complications, and treatment of neurobrucellosis: a systematic review and meta-analysis","volume":"1-1","author":"Tajerian","year":"2022","journal-title":"Int J Neurosci."},{"key":"2024012908024143600_ref10","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/s15010-021-01586-w","article-title":"The current therapeutical strategies in human brucellosis","volume":"49","author":"Bosilkovski","year":"2021","journal-title":"Infection."}],"container-title":["Oxford Medical Case 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