{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:04:40Z","timestamp":1753877080743,"version":"3.41.2"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T00:00:00Z","timestamp":1711324800000},"content-version":"vor","delay-in-days":24,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>An 80-year-old man presented in December with the main complaint of jaundice. Blood tests revealed hemolytic anemia and renal dysfunction. Positive syphilis serology results led to a diagnosis of untreated latent syphilis. A positive direct Coombs test led to a diagnosis of autoimmune hemolytic anemia (AIHA). Antibiotics were started for the syphilis, with improvement in the anemia and renal dysfunction observed. However, paroxysmal intravascular hemolysis occurred after his discharge. Based on a positive Donath-Landsteiner (D-L) test, paroxysmal cold hemoglobinuria (PCH) diagnosis was made. The hemolytic anemia improved after further treatment for syphilis, and further avoiding exposure to cold.<\/jats:p>","DOI":"10.1093\/omcr\/omae009","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T12:55:05Z","timestamp":1711371305000},"source":"Crossref","is-referenced-by-count":0,"title":["A case of paroxysmal cold hemoglobinuria complicated by latent syphilis"],"prefix":"10.1093","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2736-0733","authenticated-orcid":false,"given":"Tsuyoshi","family":"Hirata","sequence":"first","affiliation":[{"name":"Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital Department of Internal Medicine, , Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Kubota","sequence":"additional","affiliation":[{"name":"Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital Department of Internal Medicine, , Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuaki","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital Department of Infectious Diseases, , Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Takami","sequence":"additional","affiliation":[{"name":"Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital Department of Internal Medicine, , Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Kato","sequence":"additional","affiliation":[{"name":"Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital Department of Internal Medicine, , Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomomi","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital Department of Internal Medicine, , Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,3,25]]},"reference":[{"key":"2024032512545060500_ref1","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1053\/j.seminhematol.2015.05.001","article-title":"Immune Hemolysis: diagnosis and treatment recommendations","volume":"52","author":"Wilma","year":"2015","journal-title":"Semin Hematol"},{"key":"2024032512545060500_ref2","first-page":"1590","article-title":"Uber paroxysmale h\u00e4moglobinurie","volume":"51","author":"Donath","year":"1904","journal-title":"M\u00fcnch Med Wochenschr"},{"key":"2024032512545060500_ref3","doi-asserted-by":"crossref","first-page":"541","DOI":"10.3925\/jjtc.67.541","article-title":"Paroxysmal cold hemoglobinuria in Japan: a literature review","volume":"67","author":"Erina","year":"2021","journal-title":"Japanese J Transfus Cell Ther"},{"key":"2024032512545060500_ref4","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1056\/NEJMcp1900554","article-title":"Warm autoimmune Hemolytic Anemia","volume":"381","author":"Brodsky","year":"2019","journal-title":"N Engl J Med"},{"key":"2024032512545060500_ref5","doi-asserted-by":"crossref","first-page":"17028","DOI":"10.1038\/nrdp.2017.28","article-title":"Paroxysmal nocturnal haemoglobinuria","volume":"3","author":"Hill","year":"2017","journal-title":"Nat Rev Dis Primers"},{"key":"2024032512545060500_ref6","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1097\/MPH.0b013e3181f46e77","article-title":"Recurrence of paroxysmal cold hemoglobinuria in a boy after physical cooling for fever","volume":"33","author":"Mantadakis","year":"2011","journal-title":"J Pediatr Hematol Oncol"},{"key":"2024032512545060500_ref7","first-page":"20","article-title":"Paroxysmal cold hemoglobinuria in an elderly patient: a rare case with poor prognosis","volume":"2","author":"Patel","year":"2016","journal-title":"J Case Rep Images Med"}],"container-title":["Oxford Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2024\/3\/omae009\/57076346\/omae009.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2024\/3\/omae009\/57076346\/omae009.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T12:55:11Z","timestamp":1711371311000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/omcr\/article\/doi\/10.1093\/omcr\/omae009\/7634396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,1]]},"references-count":7,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/omcr\/omae009","relation":{},"ISSN":["2053-8855"],"issn-type":[{"type":"electronic","value":"2053-8855"}],"subject":[],"published-other":{"date-parts":[[2024,3]]},"published":{"date-parts":[[2024,3,1]]},"article-number":"omae009"}}