{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:08:22Z","timestamp":1790611702353,"version":"4.1.0"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T00:00:00Z","timestamp":1714089600000},"content-version":"vor","delay-in-days":25,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Erythromelalgia is a rare, highly debilitating disorder characterised by severe episodes of discomfort, erythema, and desquamation of the extremities. Its causes include genetic factors, medications, and several underlying medical conditions. This paper describes a novel cause of erythromelalgia through a case report and literature review.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case description<\/jats:title>\n                  <jats:p>A 47-year-old Caucasian man presented with a two-year history of intermittent pain, redness and desquamation of the hands. He experienced several such episodes, each lasting 3-4\u00a0weeks. A skin biopsy confirmed the diagnosis of erythromelalgia. After several recurrences, he admitted to the intermittent use of pseudoephedrine as a nasal decongestant, which coincided with the episodes of erythromelalgia. Complete resolution of symptoms was reported on cessation of this medication.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Pseudoephedrine has been reported to cause a wide range of cutaneous reactions but has not been known to precipitate erythromelalgia. Recognition of this rare side effect may offer early diagnosis and reduced morbidity.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/omcr\/omae037","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T15:23:31Z","timestamp":1714145011000},"source":"Crossref","is-referenced-by-count":3,"title":["A novel cause of erythromelalgia due to pseudoephedrine"],"prefix":"10.1093","volume":"2024","author":[{"given":"Georgios","family":"Kravvas","sequence":"first","affiliation":[{"name":"Department of Dermatology University College London Hospitals NHS Foundation Trust , London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4744-4978","authenticated-orcid":false,"given":"Nada","family":"Aboukhatwah","sequence":"additional","affiliation":[{"name":"Department of Dermatology Whittington Health NHS Foundation Trust , London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lana","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospitals Bristol NHS Foundation Trust , Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam P","family":"Bray","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospitals Bristol NHS Foundation Trust , Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,4,25]]},"reference":[{"key":"2024042615232689200_ref1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/ijd.13760","article-title":"Secondary erythromelalgia: a tryptophan dietary supplement-induced case associated with elevated 5-hydroxyindoleacetic acid (5HIAA) urinary levels","volume":"57","author":"Michelerio","year":"2018","journal-title":"Int J Dermatol"},{"key":"2024042615232689200_ref2","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1046\/j.1365-2796.1997.00185.x","article-title":"Erythromelalgia: a clinical study of 87 cases","volume":"242","author":"Kalgaard","year":"1997","journal-title":"J Intern Med"},{"key":"2024042615232689200_ref3","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1086\/320107","article-title":"The primary erythromelalgia-susceptibility gene is located on chromosome 2q31-32","volume":"68","author":"Drenth","year":"2001","journal-title":"Am J Hum Genet"},{"key":"2024042615232689200_ref4","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1067\/mjd.2000.109301","article-title":"Erythromelalgia: new theories and new therapies","volume":"43","author":"Cohen","year":"2000","journal-title":"J Am Acad Dermatol"},{"key":"2024042615232689200_ref5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1201\/9781003127147","volume-title":"Litt's Drug Eruption & Reaction Manual","author":"Shear","year":"2020","edition":"26th"},{"key":"2024042615232689200_ref6","volume-title":"Erythromelalgia: Clinical aspects, pathology and therapy","author":"Kalgaard"},{"key":"2024042615232689200_ref7","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/j.1365-4632.2008.03401.x","article-title":"Pseudoephedrine-induced acute generalized exanthematous pustulosis","volume":"47","author":"Ben Salem","year":"2008","journal-title":"Int J Dermatol"}],"container-title":["Oxford Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2024\/4\/omae037\/57331894\/omae037.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2024\/4\/omae037\/57331894\/omae037.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T15:23:35Z","timestamp":1714145015000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/omcr\/article\/doi\/10.1093\/omcr\/omae037\/7658159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,1]]},"references-count":7,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4,1]]}},"URL":"https:\/\/doi.org\/10.1093\/omcr\/omae037","relation":{},"ISSN":["2053-8855"],"issn-type":[{"value":"2053-8855","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,4]]},"published":{"date-parts":[[2024,4,1]]},"article-number":"omae037"}}