{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T02:04:32Z","timestamp":1777082672136,"version":"3.51.4"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T00:00:00Z","timestamp":1717891200000},"content-version":"vor","delay-in-days":8,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Ceftriaxone is a third-generation cephalosporin. Due to its wide range of activity and acceptable safety profile, it is frequently prescribed to paediatric patients. However, there are several documented cases of reports of uncommon adverse events, such as cholecystitis, linked to the use of ceftriaxone. This study discusses the case of an 8-year-old female patient who developed cholecystitis, an inflammation of the gallbladder, after being treated with ceftriaxone. The patient presented with right upper quadrant pain, associated with nausea. Imaging studies showed the presence of stones and shadowing sludge, leading to acute inflammation of the gallbladder. Prompt cessation of ceftriaxone and supportive treatment led to the resolution of cholecystitis and the complete disappearance of the sludge and stones. The study highlights that early identification and withdrawal of the antibiotic can lead to successful therapy and the avoidance of unnecessary surgical procedures.<\/jats:p>","DOI":"10.1093\/omcr\/omae062","type":"journal-article","created":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T14:05:33Z","timestamp":1717941933000},"source":"Crossref","is-referenced-by-count":6,"title":["Ceftriaxone-induced symptomatic cholelithiasis in a child: case report and literature review"],"prefix":"10.1093","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5977-7227","authenticated-orcid":false,"given":"Mohammad I","family":"Smerat","sequence":"first","affiliation":[{"name":"Ahli Hospital Radiology Department, , Palestine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Balqis","family":"Shawer","sequence":"additional","affiliation":[{"name":"Palestine Polytechnic University College of Medicine and Health Sciences, , Hebron, Palestine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bara M","family":"AbuIrayyeh","sequence":"additional","affiliation":[{"name":"Palestine Polytechnic University College of Medicine and Health Sciences, , Hebron, Palestine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahd T","family":"Natsheh","sequence":"additional","affiliation":[{"name":"Palestine Polytechnic University College of Medicine and Health Sciences, , Hebron, Palestine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laila","family":"Diab","sequence":"additional","affiliation":[{"name":"Palestine Polytechnic University College of Medicine and Health Sciences, , Hebron, Palestine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farah B","family":"Shahin","sequence":"additional","affiliation":[{"name":"Palestine Polytechnic University College of Medicine and Health Sciences, , Hebron, Palestine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2849-3500","authenticated-orcid":false,"given":"Mahmoud R","family":"Manasra","sequence":"additional","affiliation":[{"name":"Palestine Polytechnic University College of Medicine and Health Sciences, , Hebron, Palestine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,6,7]]},"reference":[{"key":"2024060914011229400_ref1","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1016\/0016-5085(90)90486-K","article-title":"Pathogenesis of ceftriaxone-associated biliary sludge. In vitro studies of calcium-ceftriaxone binding and solubility","volume":"99","author":"Shiffman","year":"1990","journal-title":"Gastroenterology"},{"key":"2024060914011229400_ref2","doi-asserted-by":"crossref","first-page":"288","DOI":"10.4103\/JMU.JMU_132_20","article-title":"Ceftriaxone-induced acute Cholecystitis","volume":"29","author":"Gomes","year":"2021","journal-title":"J Med Ultrasound"},{"key":"2024060914011229400_ref3","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1097\/00006454-198611000-00026","article-title":"Transient formation of precipitations in the gallbladder associated with ceftriaxone therapy","volume":"5","author":"Schaad","year":"1986","journal-title":"Pediatr Infect Dis"},{"key":"2024060914011229400_ref4","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1136\/jim-2018-000948","article-title":"Trends in the epidemiology of pediatric acute and chronic cholecystitis-related admissions in the USA: a nationwide emergency department and inpatient sample study","volume":"67","author":"Chandra","year":"2019","journal-title":"J Investig Med"},{"key":"2024060914011229400_ref5","doi-asserted-by":"crossref","first-page":"423","DOI":"10.4174\/jkss.2011.81.6.423","article-title":"Gallbladder pseudolithiasis caused by ceftriaxone in young adult","volume":"81","author":"Choi","year":"2011","journal-title":"J Korean Surg Soc"},{"key":"2024060914011229400_ref6","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.2169\/internalmedicine.8826-17","article-title":"Progressive pseudolithiasis associated with the intravenous Administration of Ceftriaxone in patients with central nervous system infections","volume":"56","author":"Tsukagoshi","year":"2017","journal-title":"Intern Med"},{"key":"2024060914011229400_ref7","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/jcu.20228","article-title":"Ceftriaxone-associated biliary pseudolithiasis in children","volume":"34","author":"Biner","year":"2006","journal-title":"J Clin Ultrasound"},{"key":"2024060914011229400_ref8","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1620\/tjem.211.285","article-title":"Pseudolithiasis due to ceftriaxone treatment for meningitis in children: report of 8 cases","volume":"211","author":"Araz","year":"2007","journal-title":"Tohoku J Exp Med"},{"key":"2024060914011229400_ref9","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1056\/NEJM199412013312222","article-title":"Pseudolithiasis and intractable hiccups in a boy receiving ceftriaxone","volume":"331","author":"Bonioli","year":"1994","journal-title":"N Engl J Med"},{"key":"2024060914011229400_ref10","doi-asserted-by":"crossref","first-page":"170","DOI":"10.14309\/crj.2014.40","article-title":"Ceftriaxone-induced gallstones: case report and literature review","volume":"1","author":"Nayak","year":"2014","journal-title":"ACG Case Rep J"}],"container-title":["Oxford Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2024\/6\/omae062\/58161781\/omae062.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2024\/6\/omae062\/58161781\/omae062.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T14:05:40Z","timestamp":1717941940000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/omcr\/article\/doi\/10.1093\/omcr\/omae062\/7689286"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,1]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/omcr\/omae062","relation":{},"ISSN":["2053-8855"],"issn-type":[{"value":"2053-8855","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,6]]},"published":{"date-parts":[[2024,6,1]]},"article-number":"omae062"}}