{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T18:26:24Z","timestamp":1783967184617,"version":"3.55.0"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T00:00:00Z","timestamp":1724716800000},"content-version":"vor","delay-in-days":26,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Melatonin, a pineal gland hormone closely associated with the circadian rhythm, has been trending over the past years as an over-the-counter medication to aid with sleep disturbances. Although generally believed to be safe, recent studies show negative inotropic and chronotropic effects on the heart rate and blood pressure in humans. Several studies suggested that melatonin induces cardiac vagal tone and affects heart rate and mean arterial pressure. Limited literature is currently available on the effects of melatonin beyond its sleep function. We present a case of a healthy 22-year-old male who visited the emergency department reporting palpitations and dizziness following the ingestion of 20\u00a0mg of melatonin. Subsequent examinations revealed marked bradycardia. Fortunately, the patient experienced spontaneous resolution of the bradycardia without necessitating intervention after a few hours of observation, and he was observed and discharged.<\/jats:p>","DOI":"10.1093\/omcr\/omae096","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T10:54:36Z","timestamp":1724756076000},"source":"Crossref","is-referenced-by-count":2,"title":["Melatonin-induced symptomatic bradycardia in an otherwise healthy male: a case report"],"prefix":"10.1093","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7780-7611","authenticated-orcid":false,"given":"Asim","family":"Alawad","sequence":"first","affiliation":[{"name":"Hamad General Hospital Emergency Medicine Department, , P.O. Box: 3050, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1574-9034","authenticated-orcid":false,"given":"Wala","family":"Sati","sequence":"additional","affiliation":[{"name":"Hamad General Hospital Emergency Medicine Department, , P.O. Box: 3050, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4499-5006","authenticated-orcid":false,"given":"Sara M I","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Hamad General Hospital Emergency Medicine Department, , P.O. Box: 3050, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2836-0334","authenticated-orcid":false,"given":"Moayed","family":"Elgassim","sequence":"additional","affiliation":[{"name":"Hamad General Hospital Emergency Medicine Department, , P.O. Box: 3050, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6556-964X","authenticated-orcid":false,"given":"Mohamad","family":"Elgassim","sequence":"additional","affiliation":[{"name":"Hamad General Hospital Emergency Medicine Department, , P.O. Box: 3050, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1170-3648","authenticated-orcid":false,"given":"Abderahman","family":"Balal","sequence":"additional","affiliation":[{"name":"Hamad General Hospital Emergency Medicine Department, , P.O. Box: 3050, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,8,26]]},"reference":[{"key":"2024082710542987900_ref1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.neuchi.2015.03.002","article-title":"Melatonin: physiological effects in humans","volume":"61","author":"Claustrat","year":"2015","journal-title":"Neurochirurgie"},{"key":"2024082710542987900_ref2","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ctim.2018.11.003","article-title":"Adverse events associated with oral administration of melatonin: a critical systematic review of clinical evidence","volume":"42","author":"Foley","year":"2019","journal-title":"Complement Ther Med"},{"key":"2024082710542987900_ref3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/1874360900901010001","article-title":"Melatonin beyond its classical functions","volume":"1","author":"Hardeland","year":"2008","journal-title":"Open 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